RAS mutations in pediatric leukemias with MLL gene rearrangements

Translocations of the MLL gene at chromosome band 11q23 are the most common cytogenetic alterations in de novo leukemia in infants and in leukemia related to chemotherapy with DNA topoisomerase II inhibitors. Experiments on knock‐in mice suggest that additional mutational events may by required for...

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Veröffentlicht in:	Genes chromosomes & cancer 1998-03, Vol.21 (3), p.270-275
Hauptverfasser:	Mahgoub, Nidal, Parker, Robert I., Hosler, Matthew R., Close, Pamelyn, Winick, Naomi J., Masterson, Margaret, Shannon, Kevin M., Felix, Carolyn A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Child Child, Preschool DNA-Binding Proteins - genetics Female Genes, ras - genetics Histone-Lysine N-Methyltransferase Humans Leukemia - genetics Leukemia, Myeloid, Acute - genetics Male Mutation - genetics Myelodysplastic Syndromes - genetics Myeloid-Lymphoid Leukemia Protein Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Proto-Oncogenes Transcription Factors Translocation, Genetic
Online-Zugang:	Volltext
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