The effects of N-methyl- D-aspartate receptor blockade with MK-801 upon the relationship between cerebral blood flow and glucose utilisation

The local cerebral circulatory and metabolic effects of MK-801, a selective non-competitive N-methyl- D-aspartate receptor antagonist have been examined in conscious rats with quantitative autoradiographic techniques using [ 14C]iodoantipyrine and [ 14C]2-deoxyglucose as tracers. Local cerebral bloo...

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Veröffentlicht in:	Brain research 1990-03, Vol.511 (2), p.271-279
Hauptverfasser:	Nehls, Daniel G., Park, Chun K., MacCormack, Alan G., McCulloch, James
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges Cerebrovascular circulation Cerebrovascular Circulation - drug effects Deoxy sugar Dibenzocycloheptenes - pharmacology Dizocilpine Maleate Fundamental and applied biological sciences. Psychology Glucose - pharmacokinetics Glutamate Male MK-801 N-Methyl- D-aspartate receptor Rats Rats, Inbred Strains Receptors, N-Methyl-D-Aspartate Receptors, Neurotransmitter - antagonists & inhibitors Receptors, Neurotransmitter - physiology Vertebrates: nervous system and sense organs
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