The role of DNA methylation in expression of the p19/p16 locus in human bladder cancer cell lines

Methylation of CpG sites in the control regions of tumor suppressor genes may be an important mechanism for their heritable, yet reversible, transcriptional inactivation. These changes in methylation may impair the proper expression and/or function of cell cycle regulatory genes and confer a selecti...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1998-03, Vol.58 (6), p.1245-1252
Hauptverfasser:	GONZALGO, M. L, HAYASHIDA, T, BENDER, C. M, PAO, M. M, TSAI, Y. C, GONZALES, F. A, NGUYEN, H. D, NGUYEN, T. T, JONES, P. A
Format:	Artikel
Sprache:	eng
Schlagworte:	Azacitidine - pharmacology Biological and medical sciences Carrier Proteins - genetics Cell Cycle Proteins CpG Islands Cyclin-Dependent Kinase Inhibitor p16 Cyclin-Dependent Kinase Inhibitor p19 DNA Methylation Down-Regulation Gene Expression Regulation, Neoplastic Genes, p16 Humans Medical sciences Nephrology. Urinary tract diseases Promoter Regions, Genetic Transcription, Genetic Tumor Cells, Cultured Tumors of the urinary system Urinary Bladder Neoplasms - genetics Urinary tract. Prostate gland
Online-Zugang:	Volltext
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