Staurosporine induces dissolution of microfilament bundles by a protein kinase C-independent pathway

The protein kinase C (PKC) inhibitor staurosporine was found to dramatically alter the actin microfilament cytoskeleton of a variety of cultured cells, including PTK2 epithelial cells, Swiss 3T3 fibroblasts, and human foreskin fibroblasts. For example, PTK2 cells exposed to 20 n M staurosporine exhi...

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Veröffentlicht in:	Experimental cell research 1990-06, Vol.188 (2), p.199-208
Hauptverfasser:	Hedberg, K.K., Birrell, G.B., Habliston, D.L., Griffith, O.H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Cytoskeleton - analysis Actin Cytoskeleton - drug effects Actin Cytoskeleton - ultrastructure Actins - analysis Alkaloids - pharmacology Animals Cell Line Cytoskeleton - drug effects Fluorescent Antibody Technique Intermediate Filaments - drug effects Intermediate Filaments - ultrastructure microfilaments Microscopy, Electron Microscopy, Fluorescence Microtubules - drug effects Microtubules - ultrastructure protein kinase C Protein Kinase C - antagonists & inhibitors Protein Kinase C - metabolism Staurosporine
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