Possible role of thyroid hormone in decreased somatomedin-C levels in diabetic and starved rats

To elucidate the possible role of thyroid hormone in somatomedin-C (SmC)/insulin-like growth factor I regulation in diabetes mellitus and starvation, plasma SmC, liver SmC, and kidney SmC concentrations were measured in streptozotocin-induced (60 mg/kg) diabetic and starved (for 72 h) rats. Triiodot...

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Veröffentlicht in:	Annals of nutrition and metabolism 1990-01, Vol.34 (1), p.8-12
Hauptverfasser:	Ikeda, Tadasu, Fujiyama, Katsumi, Hoshino, Tazue, Takeuchi, Tatsuo, Mashiba, Hiroto, Tominaga, Masato
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences blood plasma diabetes Diabetes Mellitus, Experimental - metabolism Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance fasting Insulin-Like Growth Factor I - analysis Insulin-Like Growth Factor I - metabolism Kidney - analysis Kidney - drug effects Kidney - metabolism kidneys liver Liver - analysis Liver - drug effects Liver - metabolism Male Medical sciences Original Paper Original Papers Rats Rats, Inbred Strains somatomedins Somatomedins - analysis Somatomedins - metabolism Starvation - metabolism thyroid hormones triiodothyronine Triiodothyronine - administration & dosage Triiodothyronine - blood Triiodothyronine - pharmacology
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Zusammenfassung:	To elucidate the possible role of thyroid hormone in somatomedin-C (SmC)/insulin-like growth factor I regulation in diabetes mellitus and starvation, plasma SmC, liver SmC, and kidney SmC concentrations were measured in streptozotocin-induced (60 mg/kg) diabetic and starved (for 72 h) rats. Triiodothyronine (T3, 5.0 microgram/kg every 24 h) was subcutaneously injected into diabetic rats for 7 days and into starved rats at 12, 36, and 60 h after starvation. Plasma T3, Plasma SmC, liver SmC, and kidney SmC concentrations were significantly decreased in diabetic and starved rats. T3 administration restored plasma T3 levels to the normal value in diabetic and starved rats. Plasma SmC and kidney SmC concentrations were significantly increased in T3-treated starved rats, while they were not increased in T3-treated diabetic rats. These results suggest that thyroid hormone may have some role in SmC regulation during starvation, but may have no role in diabetes mellitus in the rat.
ISSN:	0250-6807 1421-9697
DOI:	10.1159/000177564