Haloperidol induces persistent down-regulation of tyrosine hydroxylase immunoreactivity in substantia nigra but not ventral tegmental area in the rat

The dopamine antagonist haloperidol can cause tardive side-effects that may persist after the drug is withdrawn. We studied the time course of changes in dopaminergic neurons of the substantia nigra and ventral tegmental area following withdrawal of haloperidol. Rats received daily intraperitoneal i...

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Veröffentlicht in:	Neuroscience 1998-05, Vol.84 (1), p.201-211
Hauptverfasser:	Levinson, A.J, Garside, S, Rosebush, P.I, Mazurek, M.F
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals basal ganglia Biological and medical sciences Cell Count Cell Size - physiology depolarization inactivation dopamine Haloperidol - pharmacology Male Medical sciences neuroleptics Neuropharmacology oxidative stress Parkinsonism Pharmacology. Drug treatments Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopharmacology Rats Rats, Sprague-Dawley Substantia Nigra - cytology Substantia Nigra - drug effects Substantia Nigra - enzymology Tegmentum Mesencephali - cytology Tegmentum Mesencephali - drug effects Tegmentum Mesencephali - enzymology Tyrosine 3-Monooxygenase - metabolism
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