Partial or near-total pancreatectomy for persistent neonatal hyperinsulinaemic hypoglycaemia: the pathologist's role
Aims: To determine whether the presence of abnormal B‐cell nuclei predicts the existence of a focal or of a diffuse form of persistent neonatal and infantile hyperinsulinaemic hypoglycaemia in a series of 20 infants. Methods and results: Intra‐operative frozen sections were performed on small specim...
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Veröffentlicht in: | Histopathology 1998-01, Vol.32 (1), p.15-19 |
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description | Aims: To determine whether the presence of abnormal B‐cell nuclei predicts the existence of a focal or of a diffuse form of persistent neonatal and infantile hyperinsulinaemic hypoglycaemia in a series of 20 infants.
Methods and results:
Intra‐operative frozen sections were performed on small specimens from the pancreatic head, isthmus and tail. In 13 cases, abnormal B‐cell nuclei were identified, but even a near‐total pancreatectomy was insufficient to cure some of these patients, in whom no focal lesion was detected. On the other hand, abnormal insular B‐cell nuclei were not found in seven cases; based on the results of selective venous catheterization, a limited resection was performed, sufficient to cure each patient, and a focal adenomatous hyperplasia was found in each resected specimen.
Conclusions:
Intra‐operative examination of small pancreatic specimens taken from the different parts of the gland allows one to determine the type of lesion (focal or diffuse) in neonatal onset hyperinsulinaemic hypoglycaemia, and to decide on the most appropriate surgical treatment. |
doi_str_mv | 10.1046/j.1365-2559.1998.00326.x |
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Methods and results:
Intra‐operative frozen sections were performed on small specimens from the pancreatic head, isthmus and tail. In 13 cases, abnormal B‐cell nuclei were identified, but even a near‐total pancreatectomy was insufficient to cure some of these patients, in whom no focal lesion was detected. On the other hand, abnormal insular B‐cell nuclei were not found in seven cases; based on the results of selective venous catheterization, a limited resection was performed, sufficient to cure each patient, and a focal adenomatous hyperplasia was found in each resected specimen.
Conclusions:
Intra‐operative examination of small pancreatic specimens taken from the different parts of the gland allows one to determine the type of lesion (focal or diffuse) in neonatal onset hyperinsulinaemic hypoglycaemia, and to decide on the most appropriate surgical treatment.</description><identifier>ISSN: 0309-0167</identifier><identifier>EISSN: 1365-2559</identifier><identifier>DOI: 10.1046/j.1365-2559.1998.00326.x</identifier><identifier>PMID: 9522211</identifier><language>eng</language><publisher>Oxford, U.K. and Cambridge, USA: Blackwell Science Ltd</publisher><subject>Biological and medical sciences ; Cell Nucleolus - pathology ; Cell Nucleus - pathology ; Chromatin - pathology ; Diagnosis, Differential ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Frozen Sections ; Histocytochemistry ; Humans ; Hyperinsulinism - congenital ; Hyperinsulinism - pathology ; Hyperinsulinism - surgery ; Hypoglycemia - congenital ; Hypoglycemia - pathology ; Hypoglycemia - surgery ; Infant ; infantile hypoglycaemia ; Islets of Langerhans - cytology ; Islets of Langerhans - pathology ; Islets of Langerhans - ultrastructure ; Medical sciences ; Microtomy ; nesidioblastosis ; Pancreas - cytology ; Pancreas - pathology ; Pancreas - surgery ; Pancreatectomy ; Paraffin Embedding ; Prognosis ; Tumors. Hypoglycemia</subject><ispartof>Histopathology, 1998-01, Vol.32 (1), p.15-19</ispartof><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4306-7d4532e76ca28452cd5b6df9479d08160b0bdbe407ba84db25ff7b07181bbdc63</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1365-2559.1998.00326.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1365-2559.1998.00326.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,4010,27902,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2164665$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9522211$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>RAHIER, J</creatorcontrib><creatorcontrib>SEMPOUX, C</creatorcontrib><creatorcontrib>FOURNET, J. C</creatorcontrib><creatorcontrib>POGGI, F</creatorcontrib><creatorcontrib>BRUNELLE, F</creatorcontrib><creatorcontrib>NIHOUL-FEKETE, C</creatorcontrib><creatorcontrib>SAUDUBRAY, J. M</creatorcontrib><creatorcontrib>JAUBERT, F</creatorcontrib><title>Partial or near-total pancreatectomy for persistent neonatal hyperinsulinaemic hypoglycaemia: the pathologist's role</title><title>Histopathology</title><addtitle>Histopathology</addtitle><description>Aims: To determine whether the presence of abnormal B‐cell nuclei predicts the existence of a focal or of a diffuse form of persistent neonatal and infantile hyperinsulinaemic hypoglycaemia in a series of 20 infants.
Methods and results:
Intra‐operative frozen sections were performed on small specimens from the pancreatic head, isthmus and tail. In 13 cases, abnormal B‐cell nuclei were identified, but even a near‐total pancreatectomy was insufficient to cure some of these patients, in whom no focal lesion was detected. On the other hand, abnormal insular B‐cell nuclei were not found in seven cases; based on the results of selective venous catheterization, a limited resection was performed, sufficient to cure each patient, and a focal adenomatous hyperplasia was found in each resected specimen.
Conclusions:
Intra‐operative examination of small pancreatic specimens taken from the different parts of the gland allows one to determine the type of lesion (focal or diffuse) in neonatal onset hyperinsulinaemic hypoglycaemia, and to decide on the most appropriate surgical treatment.</description><subject>Biological and medical sciences</subject><subject>Cell Nucleolus - pathology</subject><subject>Cell Nucleus - pathology</subject><subject>Chromatin - pathology</subject><subject>Diagnosis, Differential</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Frozen Sections</subject><subject>Histocytochemistry</subject><subject>Humans</subject><subject>Hyperinsulinism - congenital</subject><subject>Hyperinsulinism - pathology</subject><subject>Hyperinsulinism - surgery</subject><subject>Hypoglycemia - congenital</subject><subject>Hypoglycemia - pathology</subject><subject>Hypoglycemia - surgery</subject><subject>Infant</subject><subject>infantile hypoglycaemia</subject><subject>Islets of Langerhans - cytology</subject><subject>Islets of Langerhans - pathology</subject><subject>Islets of Langerhans - ultrastructure</subject><subject>Medical sciences</subject><subject>Microtomy</subject><subject>nesidioblastosis</subject><subject>Pancreas - cytology</subject><subject>Pancreas - pathology</subject><subject>Pancreas - surgery</subject><subject>Pancreatectomy</subject><subject>Paraffin Embedding</subject><subject>Prognosis</subject><subject>Tumors. Hypoglycemia</subject><issn>0309-0167</issn><issn>1365-2559</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUuPFCEUhYnRjO3oTzCphdFVlTwKKIwbnejMJB0fGY2JGwIUNU1LFS3QsevfS9mdXruCe8937g0HACoEGwRb9nrbIMJojSkVDRKiayAkmDWHB2B1Fh6CFSRQ1BAx_hg8SWkLIeIE4wtwISjGGKEVyF9UzE75KsRqsirWOeRS7dRkolXZmhzGuRqKurMxuZTtlAsYJrVgm7l03ZT23k3Kjs4snXDvZ7NU6k2VN7bMypvgw30xv0pVDN4-BY8G5ZN9djovwfePH75d3dTrz9e3V-_WtWkJZDXvW0qw5cwo3LUUm55q1g-i5aKHHWJQQ91r20KuVdf2GtNh4Bpy1CGte8PIJXh5nLuL4ffepixHl4z1XpUX7JPkgrcCwa6A3RE0MaQU7SB30Y0qzhJBuQQut3LJVS65yiVw-S9weSjW56cdez3a_mw8JVz0FyddJaP8EEuyLp0xjFjLGC3Y2yP2x3k7__d6eXN7Vy7FXh_tyw8dznYVf0nGCafyx6druV7zr_Dn3XtJyV9u8q3N</recordid><startdate>199801</startdate><enddate>199801</enddate><creator>RAHIER, J</creator><creator>SEMPOUX, C</creator><creator>FOURNET, J. C</creator><creator>POGGI, F</creator><creator>BRUNELLE, F</creator><creator>NIHOUL-FEKETE, C</creator><creator>SAUDUBRAY, J. M</creator><creator>JAUBERT, F</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199801</creationdate><title>Partial or near-total pancreatectomy for persistent neonatal hyperinsulinaemic hypoglycaemia: the pathologist's role</title><author>RAHIER, J ; SEMPOUX, C ; FOURNET, J. C ; POGGI, F ; BRUNELLE, F ; NIHOUL-FEKETE, C ; SAUDUBRAY, J. M ; JAUBERT, F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4306-7d4532e76ca28452cd5b6df9479d08160b0bdbe407ba84db25ff7b07181bbdc63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Biological and medical sciences</topic><topic>Cell Nucleolus - pathology</topic><topic>Cell Nucleus - pathology</topic><topic>Chromatin - pathology</topic><topic>Diagnosis, Differential</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Frozen Sections</topic><topic>Histocytochemistry</topic><topic>Humans</topic><topic>Hyperinsulinism - congenital</topic><topic>Hyperinsulinism - pathology</topic><topic>Hyperinsulinism - surgery</topic><topic>Hypoglycemia - congenital</topic><topic>Hypoglycemia - pathology</topic><topic>Hypoglycemia - surgery</topic><topic>Infant</topic><topic>infantile hypoglycaemia</topic><topic>Islets of Langerhans - cytology</topic><topic>Islets of Langerhans - pathology</topic><topic>Islets of Langerhans - ultrastructure</topic><topic>Medical sciences</topic><topic>Microtomy</topic><topic>nesidioblastosis</topic><topic>Pancreas - cytology</topic><topic>Pancreas - pathology</topic><topic>Pancreas - surgery</topic><topic>Pancreatectomy</topic><topic>Paraffin Embedding</topic><topic>Prognosis</topic><topic>Tumors. Hypoglycemia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>RAHIER, J</creatorcontrib><creatorcontrib>SEMPOUX, C</creatorcontrib><creatorcontrib>FOURNET, J. C</creatorcontrib><creatorcontrib>POGGI, F</creatorcontrib><creatorcontrib>BRUNELLE, F</creatorcontrib><creatorcontrib>NIHOUL-FEKETE, C</creatorcontrib><creatorcontrib>SAUDUBRAY, J. M</creatorcontrib><creatorcontrib>JAUBERT, F</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Histopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>RAHIER, J</au><au>SEMPOUX, C</au><au>FOURNET, J. C</au><au>POGGI, F</au><au>BRUNELLE, F</au><au>NIHOUL-FEKETE, C</au><au>SAUDUBRAY, J. M</au><au>JAUBERT, F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Partial or near-total pancreatectomy for persistent neonatal hyperinsulinaemic hypoglycaemia: the pathologist's role</atitle><jtitle>Histopathology</jtitle><addtitle>Histopathology</addtitle><date>1998-01</date><risdate>1998</risdate><volume>32</volume><issue>1</issue><spage>15</spage><epage>19</epage><pages>15-19</pages><issn>0309-0167</issn><eissn>1365-2559</eissn><abstract>Aims: To determine whether the presence of abnormal B‐cell nuclei predicts the existence of a focal or of a diffuse form of persistent neonatal and infantile hyperinsulinaemic hypoglycaemia in a series of 20 infants.
Methods and results:
Intra‐operative frozen sections were performed on small specimens from the pancreatic head, isthmus and tail. In 13 cases, abnormal B‐cell nuclei were identified, but even a near‐total pancreatectomy was insufficient to cure some of these patients, in whom no focal lesion was detected. On the other hand, abnormal insular B‐cell nuclei were not found in seven cases; based on the results of selective venous catheterization, a limited resection was performed, sufficient to cure each patient, and a focal adenomatous hyperplasia was found in each resected specimen.
Conclusions:
Intra‐operative examination of small pancreatic specimens taken from the different parts of the gland allows one to determine the type of lesion (focal or diffuse) in neonatal onset hyperinsulinaemic hypoglycaemia, and to decide on the most appropriate surgical treatment.</abstract><cop>Oxford, U.K. and Cambridge, USA</cop><pub>Blackwell Science Ltd</pub><pmid>9522211</pmid><doi>10.1046/j.1365-2559.1998.00326.x</doi><tpages>5</tpages></addata></record> |
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subjects | Biological and medical sciences Cell Nucleolus - pathology Cell Nucleus - pathology Chromatin - pathology Diagnosis, Differential Endocrine pancreas. Apud cells (diseases) Endocrinopathies Frozen Sections Histocytochemistry Humans Hyperinsulinism - congenital Hyperinsulinism - pathology Hyperinsulinism - surgery Hypoglycemia - congenital Hypoglycemia - pathology Hypoglycemia - surgery Infant infantile hypoglycaemia Islets of Langerhans - cytology Islets of Langerhans - pathology Islets of Langerhans - ultrastructure Medical sciences Microtomy nesidioblastosis Pancreas - cytology Pancreas - pathology Pancreas - surgery Pancreatectomy Paraffin Embedding Prognosis Tumors. Hypoglycemia |
title | Partial or near-total pancreatectomy for persistent neonatal hyperinsulinaemic hypoglycaemia: the pathologist's role |
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