Flavopiridol Induces Apoptosis of Normal Lymphoid Cells, Causes Immunosuppression, and Has Potent Antitumor Activity In Vivo Against Human Leukemia and Lymphoma Xenografts

Flavopiridol is a novel semisynthetic flavone derivative of the alkaloid rohitukine. Flavopiridol is known to inhibit potently the activity of multiple cyclin-dependent kinases. We have assessed its effects on normal and malignant cells in preclinical animal models of localized and disseminated huma...

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Veröffentlicht in:	Blood 1998-04, Vol.91 (7), p.2482-2490
Hauptverfasser:	Arguello, Francisco, Alexander, Mark, Sterry, Judith A., Tudor, Gabriela, Smith, Erik M., Kalavar, Naina T., Greene, John F., Koss, William, Morgan, C. David, Stinson, Sherman F., Siford, Timothy J., Alvord, W. Gregory, Klabansky, Richard L., Sausville, Edward A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Apoptosis - drug effects Biological and medical sciences Chemotherapy Flavonoids - pharmacology Flavonoids - therapeutic use Growth Inhibitors - pharmacology Growth Inhibitors - therapeutic use HL-60 Cells Humans Immunosuppression Leukemia - drug therapy Leukemia - pathology Lymphocytes - drug effects Lymphocytes - pathology Lymphoma - drug therapy Lymphoma - pathology Medical sciences Mice Mice, Nude Neoplasm Transplantation Neoplasms, Experimental - drug therapy Neoplasms, Experimental - pathology Pharmacology. Drug treatments Piperidines - pharmacology Piperidines - therapeutic use
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