Vertical Transmission of Human Immunodeficiency Virus is Correlated with the Absence of High-Affinity/Avidity Maternal Antibodies to the gp120 Principal Neutralizing Domain
Many, but not all, infants born to mothers infected with the human immunodeficiency virus (HIV) are infected in utero. We have now shown that mothers who have high-affinity/avidity antibodies directed toward the principal neutralizing domain (PND) of gp120 are less likely to transmit HIV to their ch...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1990-05, Vol.87 (9), p.3445-3449 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
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| creator | Devash, Yair Calvelli, Theresa A. Wood, David G. Reagan, Kevin J. Rubinstein, Arye |
| description | Many, but not all, infants born to mothers infected with the human immunodeficiency virus (HIV) are infected in utero. We have now shown that mothers who have high-affinity/avidity antibodies directed toward the principal neutralizing domain (PND) of gp120 are less likely to transmit HIV to their children. An ELISA that preferentially measures the level of the biologically functioning, high-affinity/avidity antibodies against PND is described. In a retrospective study of 15 maternal/neonatal serum samples, the assay correctly identified the 4 uninfected and the 11 HIV-infected infants. Other clinical and laboratory parameters such as p24 antigen, phytohemagglutinin mitogenic index, and absolute surface antigen T4+cell counts did not accurately predict HIV fetal transmission. In addition to introducing a promising diagnostic tool, this study provides the in vivo evidence that protective antibodies may prevent infection by HIV. |
| doi_str_mv | 10.1073/pnas.87.9.3445 |
| format | Article |
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We have now shown that mothers who have high-affinity/avidity antibodies directed toward the principal neutralizing domain (PND) of gp120 are less likely to transmit HIV to their children. An ELISA that preferentially measures the level of the biologically functioning, high-affinity/avidity antibodies against PND is described. In a retrospective study of 15 maternal/neonatal serum samples, the assay correctly identified the 4 uninfected and the 11 HIV-infected infants. Other clinical and laboratory parameters such as p24 antigen, phytohemagglutinin mitogenic index, and absolute surface antigen T4+cell counts did not accurately predict HIV fetal transmission. In addition to introducing a promising diagnostic tool, this study provides the in vivo evidence that protective antibodies may prevent infection by HIV.</description><subject>AIDS/HIV</subject><subject>Amino Acid Sequence</subject><subject>Amino acids</subject><subject>Antibodies</subject><subject>Antigens</subject><subject>Children</subject><subject>Coatings</subject><subject>Enzyme linked immunosorbent assay</subject><subject>Female</subject><subject>HIV</subject><subject>HIV Antibodies - analysis</subject><subject>HIV Antibodies - immunology</subject><subject>HIV Envelope Protein gp120 - immunology</subject><subject>HIV Infections - immunology</subject><subject>HIV Infections - transmission</subject><subject>human immunodeficiency virus</subject><subject>Humans</subject><subject>Infants</subject><subject>Lymphocyte Activation</subject><subject>Male</subject><subject>Molecular Sequence Data</subject><subject>Mothers</subject><subject>Neutralization Tests</subject><subject>Newborns</subject><subject>Oligopeptides - chemical synthesis</subject><subject>Oligopeptides - immunology</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Infectious - immunology</subject><subject>Reference Values</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk9vFCEYxidGU7fVqydNOHmbLczAAImXzdbaJvXPofZKmAF2aWZgBaa6fiY_pEx33ayJiac34fk97_sAb1G8QnCOIK3PN07GOaNzPq8xJk-KGYIclQ3m8Gkxg7CiJcMVfl6cxngPIeSEwZPipKrruuJ4Vvy60yHZTvbgNkgXBxuj9Q54A67GQTpwPQyj80ob21ntui24s2GMwEaw9CHoXiatwHeb1iCtNVi0MUP60W5X63JhjHU2bc8XD1blCj5mPrg8beGSbb2yOoLkH72rDaog-BKs6-wmE5_0mILs7U_rVuDCD9K6F8UzI_uoX-7rWfH18v3t8qq8-fzherm4KTvMWCprzrVhjWxRpysi27YyLaSNalotm6ajmBKqoDKMGUywkiyfwbZBjVZUt8rUZ8W7Xd_N2A5addpNScQm2EGGrfDSir8VZ9di5R8EqTmi2f52bw_-26hjEvlZO9330mk_RkH5FIGQ_4KIEFYzDjM434Fd8DEGbQ5ZEBTTGohpDQSjgotpDbLhzfENDvj-348mT74_6sEvzNj3Sf9IR43-CWb99U6_j8mHozkEI4br3yQa1SI</recordid><startdate>19900501</startdate><enddate>19900501</enddate><creator>Devash, Yair</creator><creator>Calvelli, Theresa A.</creator><creator>Wood, David G.</creator><creator>Reagan, Kevin J.</creator><creator>Rubinstein, Arye</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19900501</creationdate><title>Vertical Transmission of Human Immunodeficiency Virus is Correlated with the Absence of High-Affinity/Avidity Maternal Antibodies to the gp120 Principal Neutralizing Domain</title><author>Devash, Yair ; 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| source | MEDLINE; Jstor Complete Legacy; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | AIDS/HIV Amino Acid Sequence Amino acids Antibodies Antigens Children Coatings Enzyme linked immunosorbent assay Female HIV HIV Antibodies - analysis HIV Antibodies - immunology HIV Envelope Protein gp120 - immunology HIV Infections - immunology HIV Infections - transmission human immunodeficiency virus Humans Infants Lymphocyte Activation Male Molecular Sequence Data Mothers Neutralization Tests Newborns Oligopeptides - chemical synthesis Oligopeptides - immunology Pregnancy Pregnancy Complications, Infectious - immunology Reference Values |
| title | Vertical Transmission of Human Immunodeficiency Virus is Correlated with the Absence of High-Affinity/Avidity Maternal Antibodies to the gp120 Principal Neutralizing Domain |
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