Antitumor activity of actinonin in vitro and in vivo

Actinonin, an antibiotic and CD13/aminopeptidase N (APN) inhibitor, has been shown to be cytotoxic to tumor cell lines in vitro. We investigated the antiproliferative effects of actinonin on human and murine leukemia and lymphoma cells. Actinonin inhibited growth of NB4 and HL60 human cell lines and...

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Veröffentlicht in:	Clinical cancer research 1998-01, Vol.4 (1), p.171-176
Hauptverfasser:	XU, Y, LAI, L. T, GABRILOVE, J. L, SCHEINBERG, D. A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics, Antineoplastic - pharmacology Antineoplastic agents Apoptosis - drug effects Biological and medical sciences Bone Marrow Cells - drug effects Chemotherapy Female G1 Phase - drug effects Humans Hydroxamic Acids - pharmacology Leukemia, Experimental - drug therapy Medical sciences Mice Mice, Inbred AKR Pharmacology. Drug treatments Tumor Cells, Cultured
Online-Zugang:	Volltext
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