Cerebrospinal fluid HIV-1 RNA levels : correlation with HIV encephalitis
Neuropathological abnormalities induced by HIV-1 are not always predictable on the basis of the presence of HIV-related neurological symptoms. HIV-1 RNA load was measured in the cerebrospinal fluid (CSF) of HIV-infected patients to verify whether it could be a marker of HIV-induced neuropathology. H...
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| Veröffentlicht in: | AIDS (London) 1998-03, Vol.12 (4), p.389-394 |
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| creator | CINQUE, P VAGO, L CERESA, D MAININI, F TERRENI, M. R VAGANI, A TORRI, W BOSSOLASCO, S LAZZARIN, A |
| description | Neuropathological abnormalities induced by HIV-1 are not always predictable on the basis of the presence of HIV-related neurological symptoms. HIV-1 RNA load was measured in the cerebrospinal fluid (CSF) of HIV-infected patients to verify whether it could be a marker of HIV-induced neuropathology.
Histopathological and immunohistochemical examination of the brain for HIV-1 p24 antigen was performed in 50 HIV-infected patients with neurological symptoms; patients were defined as having HIV encephalitis in the presence of HIV-related lesions or HIV-1 p24 antigen-positive cells. Quantitative polymerase chain reaction for HIV-1 RNA was retrospectively applied to CSF samples that had been drawn 1-60 days prior to death from these 50 patients; paired plasma samples of 28 patients were also analysed.
The CSF HIV-1 RNA copy numbers were significantly higher in 22 patients with HIV encephalitis than in 28 patients without (median, 4.77 log10 versus 3.45 log10 copies/ml; P = 0.0003). No correlation was found between CSF HIV-1 RNA load and the presence of opportunistic brain pathologies at post-mortem examination or between HIV-1 RNA loads in paired CSF and plasma samples.
High CSF HIV-1 RNA levels are associated with HIV encephalitis, regardless of the presence of opportunistic brain diseases or HIV-1 RNA levels in plasma. Quantitative CSF HIV-1 RNA may therefore be used as a specific marker of HIV-induced neuropathology. |
| doi_str_mv | 10.1097/00002030-199804000-00007 |
| format | Article |
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Histopathological and immunohistochemical examination of the brain for HIV-1 p24 antigen was performed in 50 HIV-infected patients with neurological symptoms; patients were defined as having HIV encephalitis in the presence of HIV-related lesions or HIV-1 p24 antigen-positive cells. Quantitative polymerase chain reaction for HIV-1 RNA was retrospectively applied to CSF samples that had been drawn 1-60 days prior to death from these 50 patients; paired plasma samples of 28 patients were also analysed.
The CSF HIV-1 RNA copy numbers were significantly higher in 22 patients with HIV encephalitis than in 28 patients without (median, 4.77 log10 versus 3.45 log10 copies/ml; P = 0.0003). No correlation was found between CSF HIV-1 RNA load and the presence of opportunistic brain pathologies at post-mortem examination or between HIV-1 RNA loads in paired CSF and plasma samples.
High CSF HIV-1 RNA levels are associated with HIV encephalitis, regardless of the presence of opportunistic brain diseases or HIV-1 RNA levels in plasma. Quantitative CSF HIV-1 RNA may therefore be used as a specific marker of HIV-induced neuropathology.</description><identifier>ISSN: 0269-9370</identifier><identifier>EISSN: 1473-5571</identifier><identifier>DOI: 10.1097/00002030-199804000-00007</identifier><identifier>PMID: 9520168</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adult ; Aged ; AIDS Dementia Complex - blood ; AIDS Dementia Complex - cerebrospinal fluid ; AIDS Dementia Complex - pathology ; AIDS Dementia Complex - virology ; AIDS-Related Opportunistic Infections - pathology ; AIDS-Related Opportunistic Infections - virology ; AIDS/HIV ; Biological and medical sciences ; Brain - pathology ; Brain - virology ; Cerebrospinal Fluid - virology ; Female ; HIV Core Protein p24 - analysis ; HIV-1 - genetics ; HIV-1 - physiology ; Human viral diseases ; Humans ; Infectious diseases ; Male ; Medical sciences ; Middle Aged ; Polymerase Chain Reaction ; RNA, Viral - analysis ; RNA, Viral - blood ; RNA, Viral - cerebrospinal fluid ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids ; Viral Load</subject><ispartof>AIDS (London), 1998-03, Vol.12 (4), p.389-394</ispartof><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c344t-f88928050947e6ddaabe50a3f8942d892392916c70144b167fd4109e69450b043</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2160049$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9520168$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CINQUE, P</creatorcontrib><creatorcontrib>VAGO, L</creatorcontrib><creatorcontrib>CERESA, D</creatorcontrib><creatorcontrib>MAININI, F</creatorcontrib><creatorcontrib>TERRENI, M. R</creatorcontrib><creatorcontrib>VAGANI, A</creatorcontrib><creatorcontrib>TORRI, W</creatorcontrib><creatorcontrib>BOSSOLASCO, S</creatorcontrib><creatorcontrib>LAZZARIN, A</creatorcontrib><title>Cerebrospinal fluid HIV-1 RNA levels : correlation with HIV encephalitis</title><title>AIDS (London)</title><addtitle>AIDS</addtitle><description>Neuropathological abnormalities induced by HIV-1 are not always predictable on the basis of the presence of HIV-related neurological symptoms. HIV-1 RNA load was measured in the cerebrospinal fluid (CSF) of HIV-infected patients to verify whether it could be a marker of HIV-induced neuropathology.
Histopathological and immunohistochemical examination of the brain for HIV-1 p24 antigen was performed in 50 HIV-infected patients with neurological symptoms; patients were defined as having HIV encephalitis in the presence of HIV-related lesions or HIV-1 p24 antigen-positive cells. Quantitative polymerase chain reaction for HIV-1 RNA was retrospectively applied to CSF samples that had been drawn 1-60 days prior to death from these 50 patients; paired plasma samples of 28 patients were also analysed.
The CSF HIV-1 RNA copy numbers were significantly higher in 22 patients with HIV encephalitis than in 28 patients without (median, 4.77 log10 versus 3.45 log10 copies/ml; P = 0.0003). No correlation was found between CSF HIV-1 RNA load and the presence of opportunistic brain pathologies at post-mortem examination or between HIV-1 RNA loads in paired CSF and plasma samples.
High CSF HIV-1 RNA levels are associated with HIV encephalitis, regardless of the presence of opportunistic brain diseases or HIV-1 RNA levels in plasma. Quantitative CSF HIV-1 RNA may therefore be used as a specific marker of HIV-induced neuropathology.</description><subject>Adult</subject><subject>Aged</subject><subject>AIDS Dementia Complex - blood</subject><subject>AIDS Dementia Complex - cerebrospinal fluid</subject><subject>AIDS Dementia Complex - pathology</subject><subject>AIDS Dementia Complex - virology</subject><subject>AIDS-Related Opportunistic Infections - pathology</subject><subject>AIDS-Related Opportunistic Infections - virology</subject><subject>AIDS/HIV</subject><subject>Biological and medical sciences</subject><subject>Brain - pathology</subject><subject>Brain - virology</subject><subject>Cerebrospinal Fluid - virology</subject><subject>Female</subject><subject>HIV Core Protein p24 - analysis</subject><subject>HIV-1 - genetics</subject><subject>HIV-1 - physiology</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Polymerase Chain Reaction</subject><subject>RNA, Viral - analysis</subject><subject>RNA, Viral - blood</subject><subject>RNA, Viral - cerebrospinal fluid</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. Aids</subject><subject>Viral Load</subject><issn>0269-9370</issn><issn>1473-5571</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkF1PwyAUhonRzDn9CSZcGO_QQ0v58M4s6pYsmhj1tqEtzTCsrdBq_PdSN3crN4TzPucAD0KYwhUFJa4hrgRSIFQpCSyeyFgSB2hKmUhJlgl6iKaQcEVUKuAYnYTwHokMpJygicoSoFxO0WJuvCl8GzrbaIdrN9gKL5ZvhOLnx1vszKdxAd_gsvXeON3btsFftl-PDDZNabq1dra34RQd1doFc7bbZ-j1_u5lviCrp4fl_HZFypSxntRSqkTGZygmDK8qrQuTgU5rqVhSxSxViaK8FEAZKygXdcXijw1XLIMCWDpDl9u5nW8_BhP6fGNDaZzTjWmHkAslmEio-heknDGRsXGi3IJl1BC8qfPO24323zmFfLSd_9nO97Z_SyK2nu_uGIqNqfaNO70xv9jlOpTa1V43pQ17LKEcgKn0B7W7g7M</recordid><startdate>19980305</startdate><enddate>19980305</enddate><creator>CINQUE, P</creator><creator>VAGO, L</creator><creator>CERESA, D</creator><creator>MAININI, F</creator><creator>TERRENI, M. R</creator><creator>VAGANI, A</creator><creator>TORRI, W</creator><creator>BOSSOLASCO, S</creator><creator>LAZZARIN, A</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19980305</creationdate><title>Cerebrospinal fluid HIV-1 RNA levels : correlation with HIV encephalitis</title><author>CINQUE, P ; VAGO, L ; CERESA, D ; MAININI, F ; TERRENI, M. R ; VAGANI, A ; TORRI, W ; BOSSOLASCO, S ; LAZZARIN, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c344t-f88928050947e6ddaabe50a3f8942d892392916c70144b167fd4109e69450b043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adult</topic><topic>Aged</topic><topic>AIDS Dementia Complex - blood</topic><topic>AIDS Dementia Complex - cerebrospinal fluid</topic><topic>AIDS Dementia Complex - pathology</topic><topic>AIDS Dementia Complex - virology</topic><topic>AIDS-Related Opportunistic Infections - pathology</topic><topic>AIDS-Related Opportunistic Infections - virology</topic><topic>AIDS/HIV</topic><topic>Biological and medical sciences</topic><topic>Brain - pathology</topic><topic>Brain - virology</topic><topic>Cerebrospinal Fluid - virology</topic><topic>Female</topic><topic>HIV Core Protein p24 - analysis</topic><topic>HIV-1 - genetics</topic><topic>HIV-1 - physiology</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Polymerase Chain Reaction</topic><topic>RNA, Viral - analysis</topic><topic>RNA, Viral - blood</topic><topic>RNA, Viral - cerebrospinal fluid</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. Aids</topic><topic>Viral Load</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CINQUE, P</creatorcontrib><creatorcontrib>VAGO, L</creatorcontrib><creatorcontrib>CERESA, D</creatorcontrib><creatorcontrib>MAININI, F</creatorcontrib><creatorcontrib>TERRENI, M. R</creatorcontrib><creatorcontrib>VAGANI, A</creatorcontrib><creatorcontrib>TORRI, W</creatorcontrib><creatorcontrib>BOSSOLASCO, S</creatorcontrib><creatorcontrib>LAZZARIN, A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>AIDS (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CINQUE, P</au><au>VAGO, L</au><au>CERESA, D</au><au>MAININI, F</au><au>TERRENI, M. R</au><au>VAGANI, A</au><au>TORRI, W</au><au>BOSSOLASCO, S</au><au>LAZZARIN, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cerebrospinal fluid HIV-1 RNA levels : correlation with HIV encephalitis</atitle><jtitle>AIDS (London)</jtitle><addtitle>AIDS</addtitle><date>1998-03-05</date><risdate>1998</risdate><volume>12</volume><issue>4</issue><spage>389</spage><epage>394</epage><pages>389-394</pages><issn>0269-9370</issn><eissn>1473-5571</eissn><abstract>Neuropathological abnormalities induced by HIV-1 are not always predictable on the basis of the presence of HIV-related neurological symptoms. HIV-1 RNA load was measured in the cerebrospinal fluid (CSF) of HIV-infected patients to verify whether it could be a marker of HIV-induced neuropathology.
Histopathological and immunohistochemical examination of the brain for HIV-1 p24 antigen was performed in 50 HIV-infected patients with neurological symptoms; patients were defined as having HIV encephalitis in the presence of HIV-related lesions or HIV-1 p24 antigen-positive cells. Quantitative polymerase chain reaction for HIV-1 RNA was retrospectively applied to CSF samples that had been drawn 1-60 days prior to death from these 50 patients; paired plasma samples of 28 patients were also analysed.
The CSF HIV-1 RNA copy numbers were significantly higher in 22 patients with HIV encephalitis than in 28 patients without (median, 4.77 log10 versus 3.45 log10 copies/ml; P = 0.0003). No correlation was found between CSF HIV-1 RNA load and the presence of opportunistic brain pathologies at post-mortem examination or between HIV-1 RNA loads in paired CSF and plasma samples.
High CSF HIV-1 RNA levels are associated with HIV encephalitis, regardless of the presence of opportunistic brain diseases or HIV-1 RNA levels in plasma. Quantitative CSF HIV-1 RNA may therefore be used as a specific marker of HIV-induced neuropathology.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>9520168</pmid><doi>10.1097/00002030-199804000-00007</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0269-9370 |
| ispartof | AIDS (London), 1998-03, Vol.12 (4), p.389-394 |
| issn | 0269-9370 1473-5571 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79747219 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Journals@Ovid Complete |
| subjects | Adult Aged AIDS Dementia Complex - blood AIDS Dementia Complex - cerebrospinal fluid AIDS Dementia Complex - pathology AIDS Dementia Complex - virology AIDS-Related Opportunistic Infections - pathology AIDS-Related Opportunistic Infections - virology AIDS/HIV Biological and medical sciences Brain - pathology Brain - virology Cerebrospinal Fluid - virology Female HIV Core Protein p24 - analysis HIV-1 - genetics HIV-1 - physiology Human viral diseases Humans Infectious diseases Male Medical sciences Middle Aged Polymerase Chain Reaction RNA, Viral - analysis RNA, Viral - blood RNA, Viral - cerebrospinal fluid Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral Load |
| title | Cerebrospinal fluid HIV-1 RNA levels : correlation with HIV encephalitis |
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