Exercise-Induced Oxidative Stress in Patients During Thallium Stress Testing
Free radical injury is implicated ~n the ~athogenesis of coronary artery disease, ~ncludmg atherogenesis and reperfusionlinJUry. Strenuous physical exercise can cause oxidative stress by several mechanisms, includingreperfusionlinjury. We hypothesize that exercise- induced lipid peroxidation is grea...
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| Veröffentlicht in: | The American journal of the medical sciences 1998-03, Vol.315 (3), p.185-187 |
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| container_title | The American journal of the medical sciences |
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| creator | Kleinman, Michael T. Alexander Leaf, David Yusin, Mark Gallik, Donna |
| description | Free radical injury is implicated ~n the ~athogenesis of coronary artery disease, ~ncludmg atherogenesis and reperfusionlinJUry. Strenuous physical exercise can cause oxidative stress by several mechanisms, includingreperfusionlinjury. We hypothesize that exercise- induced lipid peroxidation is greater among those with than those without exerciseinduced myocardial ischemia.
Methods: The effect of physical exercise stress testing on plasma malonaldehyde (MDA) levels was compared between patients with (Group A, N = 8) and without (Group B) exer~ ise-i!lduced myocardial ischemia by thallium ImagIng.
Analysis: Two-way ANOVA was used to compare plasma MDA levels pre- and post-exercise and paired t-test comparisons were conducted for percent MDA changes between Group A and Group B patients.
Results: Two-way ANOVA revealed a significant (P = 0.002) directional difference in response to exercise between the groups' mean plasma MDA levels (Group A increased by 46 ± 12.7 percent, Group B decreased by 16.8 ± 4.6 percent).
Conclusions: Differences in exercise-induced lipid peroxidation between patients with and without thallium documentation of myocar~ ial ischemia have important implications In the development of clinical markers of coronary artery disease and further research related to atherogenesis. |
| doi_str_mv | 10.1016/S0002-9629(15)40303-9 |
| format | Article |
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Methods: The effect of physical exercise stress testing on plasma malonaldehyde (MDA) levels was compared between patients with (Group A, N = 8) and without (Group B) exer~ ise-i!lduced myocardial ischemia by thallium ImagIng.
Analysis: Two-way ANOVA was used to compare plasma MDA levels pre- and post-exercise and paired t-test comparisons were conducted for percent MDA changes between Group A and Group B patients.
Results: Two-way ANOVA revealed a significant (P = 0.002) directional difference in response to exercise between the groups' mean plasma MDA levels (Group A increased by 46 ± 12.7 percent, Group B decreased by 16.8 ± 4.6 percent).
Conclusions: Differences in exercise-induced lipid peroxidation between patients with and without thallium documentation of myocar~ ial ischemia have important implications In the development of clinical markers of coronary artery disease and further research related to atherogenesis.</description><identifier>ISSN: 0002-9629</identifier><identifier>EISSN: 1538-2990</identifier><identifier>DOI: 10.1016/S0002-9629(15)40303-9</identifier><identifier>PMID: 9519931</identifier><identifier>CODEN: AJMSA9</identifier><language>eng</language><publisher>Hagerstown, MD: Elsevier Inc</publisher><subject>Aged ; Biological and medical sciences ; Cardiovascular system ; Exercise ; Exercise Test ; Female ; Humans ; Lipid peroxidation ; Male ; Malondialdehyde - blood ; Medical sciences ; Middle Aged ; Miscellaneous ; Myocardial ischemia ; Oxidative Stress ; Pharmacology. Drug treatments ; Prospective Studies ; Thallium ; Tomography, Emission-Computed, Single-Photon</subject><ispartof>The American journal of the medical sciences, 1998-03, Vol.315 (3), p.185-187</ispartof><rights>1998 Southern Society for Clinical Investigation</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c1841-b1ccc2f4ea50c801815c86308c1675fcc039a7af65bb0bdf78d7145861385d113</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2177323$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9519931$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kleinman, Michael T.</creatorcontrib><creatorcontrib>Alexander Leaf, David</creatorcontrib><creatorcontrib>Yusin, Mark</creatorcontrib><creatorcontrib>Gallik, Donna</creatorcontrib><title>Exercise-Induced Oxidative Stress in Patients During Thallium Stress Testing</title><title>The American journal of the medical sciences</title><addtitle>Am J Med Sci</addtitle><description>Free radical injury is implicated ~n the ~athogenesis of coronary artery disease, ~ncludmg atherogenesis and reperfusionlinJUry. Strenuous physical exercise can cause oxidative stress by several mechanisms, includingreperfusionlinjury. We hypothesize that exercise- induced lipid peroxidation is greater among those with than those without exerciseinduced myocardial ischemia.
Methods: The effect of physical exercise stress testing on plasma malonaldehyde (MDA) levels was compared between patients with (Group A, N = 8) and without (Group B) exer~ ise-i!lduced myocardial ischemia by thallium ImagIng.
Analysis: Two-way ANOVA was used to compare plasma MDA levels pre- and post-exercise and paired t-test comparisons were conducted for percent MDA changes between Group A and Group B patients.
Results: Two-way ANOVA revealed a significant (P = 0.002) directional difference in response to exercise between the groups' mean plasma MDA levels (Group A increased by 46 ± 12.7 percent, Group B decreased by 16.8 ± 4.6 percent).
Conclusions: Differences in exercise-induced lipid peroxidation between patients with and without thallium documentation of myocar~ ial ischemia have important implications In the development of clinical markers of coronary artery disease and further research related to atherogenesis.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Cardiovascular system</subject><subject>Exercise</subject><subject>Exercise Test</subject><subject>Female</subject><subject>Humans</subject><subject>Lipid peroxidation</subject><subject>Male</subject><subject>Malondialdehyde - blood</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Myocardial ischemia</subject><subject>Oxidative Stress</subject><subject>Pharmacology. Drug treatments</subject><subject>Prospective Studies</subject><subject>Thallium</subject><subject>Tomography, Emission-Computed, Single-Photon</subject><issn>0002-9629</issn><issn>1538-2990</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkF1LwzAUhoMoc05_wqAXInpRzWmaNrkSmfMDBhM2r0Oaphrpx0zaMf-92VZ369WB9zzngwehMeBbwJDcLTDGUciTiF8DvYkxwSTkR2gIlLAw4hwfo-EBOUVnzn1hDBEDMkADToFzAkM0m260Vcbp8LXOO6XzYL4xuWzNWgeL1mrnAlMHbz7QdeuCx86a-iNYfsqyNF31hyy1a31-jk4KWTp90dcRen-aLicv4Wz-_Dp5mIUKWAxhBkqpqIi1pFgxDAyoYgnBTEGS0kIpTLhMZZHQLMNZXqQsTyGmLAHCaA5ARuhqv3dlm-_O3xaVcUqXpax10zmR8jSmNGEepHtQ2cY5qwuxsqaS9kcAFluLYmdRbBUJoGJnUXA_N-4PdFml88NUr833L_u-dEqWhZW1d3jAIkhTEhGP3e8x7WWsjbbCKe_RWzZWq1bkjfnnkV-q_o2D</recordid><startdate>199803</startdate><enddate>199803</enddate><creator>Kleinman, Michael T.</creator><creator>Alexander Leaf, David</creator><creator>Yusin, Mark</creator><creator>Gallik, Donna</creator><general>Elsevier Inc</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199803</creationdate><title>Exercise-Induced Oxidative Stress in Patients During Thallium Stress Testing</title><author>Kleinman, Michael T. ; Alexander Leaf, David ; Yusin, Mark ; Gallik, Donna</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1841-b1ccc2f4ea50c801815c86308c1675fcc039a7af65bb0bdf78d7145861385d113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Cardiovascular system</topic><topic>Exercise</topic><topic>Exercise Test</topic><topic>Female</topic><topic>Humans</topic><topic>Lipid peroxidation</topic><topic>Male</topic><topic>Malondialdehyde - blood</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Myocardial ischemia</topic><topic>Oxidative Stress</topic><topic>Pharmacology. Drug treatments</topic><topic>Prospective Studies</topic><topic>Thallium</topic><topic>Tomography, Emission-Computed, Single-Photon</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kleinman, Michael T.</creatorcontrib><creatorcontrib>Alexander Leaf, David</creatorcontrib><creatorcontrib>Yusin, Mark</creatorcontrib><creatorcontrib>Gallik, Donna</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of the medical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kleinman, Michael T.</au><au>Alexander Leaf, David</au><au>Yusin, Mark</au><au>Gallik, Donna</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exercise-Induced Oxidative Stress in Patients During Thallium Stress Testing</atitle><jtitle>The American journal of the medical sciences</jtitle><addtitle>Am J Med Sci</addtitle><date>1998-03</date><risdate>1998</risdate><volume>315</volume><issue>3</issue><spage>185</spage><epage>187</epage><pages>185-187</pages><issn>0002-9629</issn><eissn>1538-2990</eissn><coden>AJMSA9</coden><abstract>Free radical injury is implicated ~n the ~athogenesis of coronary artery disease, ~ncludmg atherogenesis and reperfusionlinJUry. Strenuous physical exercise can cause oxidative stress by several mechanisms, includingreperfusionlinjury. We hypothesize that exercise- induced lipid peroxidation is greater among those with than those without exerciseinduced myocardial ischemia.
Methods: The effect of physical exercise stress testing on plasma malonaldehyde (MDA) levels was compared between patients with (Group A, N = 8) and without (Group B) exer~ ise-i!lduced myocardial ischemia by thallium ImagIng.
Analysis: Two-way ANOVA was used to compare plasma MDA levels pre- and post-exercise and paired t-test comparisons were conducted for percent MDA changes between Group A and Group B patients.
Results: Two-way ANOVA revealed a significant (P = 0.002) directional difference in response to exercise between the groups' mean plasma MDA levels (Group A increased by 46 ± 12.7 percent, Group B decreased by 16.8 ± 4.6 percent).
Conclusions: Differences in exercise-induced lipid peroxidation between patients with and without thallium documentation of myocar~ ial ischemia have important implications In the development of clinical markers of coronary artery disease and further research related to atherogenesis.</abstract><cop>Hagerstown, MD</cop><pub>Elsevier Inc</pub><pmid>9519931</pmid><doi>10.1016/S0002-9629(15)40303-9</doi><tpages>3</tpages></addata></record> |
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| source | MEDLINE; Alma/SFX Local Collection; Journals@Ovid Complete |
| subjects | Aged Biological and medical sciences Cardiovascular system Exercise Exercise Test Female Humans Lipid peroxidation Male Malondialdehyde - blood Medical sciences Middle Aged Miscellaneous Myocardial ischemia Oxidative Stress Pharmacology. Drug treatments Prospective Studies Thallium Tomography, Emission-Computed, Single-Photon |
| title | Exercise-Induced Oxidative Stress in Patients During Thallium Stress Testing |
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