Chronic Hyperinsulinemia and Blood Pressure Interaction With Catecholamines?

Although hyperinsulinemia and increased adrenergic activity have been postulated to be important factors in obesity-associated hypertension, a cause and effect relation between insulin, catecholamines, and hypertension has not been established. The aim of this study was to determine whether chronic...

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Veröffentlicht in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 1990-05, Vol.15 (5), p.519-527
Hauptverfasser: Hall, John E, Brands, Michael W, Kivlighn, Salah D, Mizelle, H Leland, Hildebrandt, Drew A, Gaillard, Carlo A
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container_end_page 527
container_issue 5
container_start_page 519
container_title Hypertension (Dallas, Tex. 1979)
container_volume 15
creator Hall, John E
Brands, Michael W
Kivlighn, Salah D
Mizelle, H Leland
Hildebrandt, Drew A
Gaillard, Carlo A
description Although hyperinsulinemia and increased adrenergic activity have been postulated to be important factors in obesity-associated hypertension, a cause and effect relation between insulin, catecholamines, and hypertension has not been established. The aim of this study was to determine whether chronic hyperinsulinemia, comparable with that found in obese hypertensive patients, causes hypertension in normal dogs, increases plasma catecholamines, or potentiates the blood pressure effects of norepinephrine. In six normal dogs, insulin infusion (1.0 milliunits/ kg/min) for 7 days, with euglycemia maintained, increased fasting insulin fourfold to sixfold. However, mean arterial pressure did not increase, averaging 99±2 mm Hg during the control period and 91±3 mm Hg during the 7 days of insulin infusion. Insulin did not alter plasma norepinephrine or epinephrine, which averaged 171±27 and 71±14 pg/ml, respectively, during the control period and 188±29 and 45±12 pg/ml during the 7 days of insulin infusion. In six dogs, norepinephrine was infused (0.2 μg/kg/min) for 7 days to raise plasma norepinephrine to 2,940±103 pg/ml. Insulin infusion (1.0 milliunits/kg/min) for 7 days during simultaneous infusion of norepinephrine did not further increase mean arterial pressure, which averaged 101±3 during norepinephrine and 98±2 mm Hg during insulin plus norepinephrine infusion. Thus, chronic hyperinsulinemia did not increase mean arterial pressure or plasma catecholamines and did not potentiate the blood pressure actions of norepinephrine. These observations provide no evidence that chronic hyperinsulinemia or interactions between insulin and plasma catecholamines cause hypertension in normal dogs.
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The aim of this study was to determine whether chronic hyperinsulinemia, comparable with that found in obese hypertensive patients, causes hypertension in normal dogs, increases plasma catecholamines, or potentiates the blood pressure effects of norepinephrine. In six normal dogs, insulin infusion (1.0 milliunits/ kg/min) for 7 days, with euglycemia maintained, increased fasting insulin fourfold to sixfold. However, mean arterial pressure did not increase, averaging 99±2 mm Hg during the control period and 91±3 mm Hg during the 7 days of insulin infusion. Insulin did not alter plasma norepinephrine or epinephrine, which averaged 171±27 and 71±14 pg/ml, respectively, during the control period and 188±29 and 45±12 pg/ml during the 7 days of insulin infusion. In six dogs, norepinephrine was infused (0.2 μg/kg/min) for 7 days to raise plasma norepinephrine to 2,940±103 pg/ml. Insulin infusion (1.0 milliunits/kg/min) for 7 days during simultaneous infusion of norepinephrine did not further increase mean arterial pressure, which averaged 101±3 during norepinephrine and 98±2 mm Hg during insulin plus norepinephrine infusion. Thus, chronic hyperinsulinemia did not increase mean arterial pressure or plasma catecholamines and did not potentiate the blood pressure actions of norepinephrine. 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Psychology</subject><subject>Glomerular Filtration Rate - drug effects</subject><subject>Hemodynamics. 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Psychology</topic><topic>Glomerular Filtration Rate - drug effects</topic><topic>Hemodynamics. Rheology</topic><topic>Infusions, Intravenous</topic><topic>Insulin - blood</topic><topic>Insulin - pharmacology</topic><topic>Norepinephrine - blood</topic><topic>Norepinephrine - pharmacology</topic><topic>Norepinephrine - physiology</topic><topic>Osmolar Concentration</topic><topic>Potassium - urine</topic><topic>Reference Values</topic><topic>Sodium - metabolism</topic><topic>Vertebrates: cardiovascular system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hall, John E</creatorcontrib><creatorcontrib>Brands, Michael W</creatorcontrib><creatorcontrib>Kivlighn, Salah D</creatorcontrib><creatorcontrib>Mizelle, H Leland</creatorcontrib><creatorcontrib>Hildebrandt, Drew A</creatorcontrib><creatorcontrib>Gaillard, Carlo A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hall, John E</au><au>Brands, Michael W</au><au>Kivlighn, Salah D</au><au>Mizelle, H Leland</au><au>Hildebrandt, Drew A</au><au>Gaillard, Carlo A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chronic Hyperinsulinemia and Blood Pressure Interaction With Catecholamines?</atitle><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle><addtitle>Hypertension</addtitle><date>1990-05</date><risdate>1990</risdate><volume>15</volume><issue>5</issue><spage>519</spage><epage>527</epage><pages>519-527</pages><issn>0194-911X</issn><eissn>1524-4563</eissn><coden>HPRTDN</coden><abstract>Although hyperinsulinemia and increased adrenergic activity have been postulated to be important factors in obesity-associated hypertension, a cause and effect relation between insulin, catecholamines, and hypertension has not been established. The aim of this study was to determine whether chronic hyperinsulinemia, comparable with that found in obese hypertensive patients, causes hypertension in normal dogs, increases plasma catecholamines, or potentiates the blood pressure effects of norepinephrine. In six normal dogs, insulin infusion (1.0 milliunits/ kg/min) for 7 days, with euglycemia maintained, increased fasting insulin fourfold to sixfold. However, mean arterial pressure did not increase, averaging 99±2 mm Hg during the control period and 91±3 mm Hg during the 7 days of insulin infusion. Insulin did not alter plasma norepinephrine or epinephrine, which averaged 171±27 and 71±14 pg/ml, respectively, during the control period and 188±29 and 45±12 pg/ml during the 7 days of insulin infusion. In six dogs, norepinephrine was infused (0.2 μg/kg/min) for 7 days to raise plasma norepinephrine to 2,940±103 pg/ml. Insulin infusion (1.0 milliunits/kg/min) for 7 days during simultaneous infusion of norepinephrine did not further increase mean arterial pressure, which averaged 101±3 during norepinephrine and 98±2 mm Hg during insulin plus norepinephrine infusion. Thus, chronic hyperinsulinemia did not increase mean arterial pressure or plasma catecholamines and did not potentiate the blood pressure actions of norepinephrine. These observations provide no evidence that chronic hyperinsulinemia or interactions between insulin and plasma catecholamines cause hypertension in normal dogs.</abstract><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>American Heart Association, Inc</pub><pmid>2185153</pmid><doi>10.1161/01.HYP.15.5.519</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record>
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source MEDLINE; American Heart Association Journals; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals
subjects Animals
Biological and medical sciences
Blood Pressure - drug effects
Dogs
Epinephrine - blood
Epinephrine - pharmacology
Epinephrine - physiology
Fundamental and applied biological sciences. Psychology
Glomerular Filtration Rate - drug effects
Hemodynamics. Rheology
Infusions, Intravenous
Insulin - blood
Insulin - pharmacology
Norepinephrine - blood
Norepinephrine - pharmacology
Norepinephrine - physiology
Osmolar Concentration
Potassium - urine
Reference Values
Sodium - metabolism
Vertebrates: cardiovascular system
title Chronic Hyperinsulinemia and Blood Pressure Interaction With Catecholamines?
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