Extracellular Calcium Deprivation in Astrocytes: Regulation of mRNA Expression and Apoptosis

: Cell viability and gene expression were studied in primary astroglial cells cultured in a nominally calcium‐free medium. Ca2+ deprivation reduced progressively the astrocytes' viability, starting from 12 h; the restoration of a normal Ca2+ concentration (1.8 mM) in the medium after 12‐h depri...

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Veröffentlicht in:	Journal of neurochemistry 1998-04, Vol.70 (4), p.1474-1483
Hauptverfasser:	Chiesa, Roberto, Angeretti, Nadia, Del Bo, Roberto, Lucca, Elisa, Munna, Elettra, Forloni, Gianluigi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - physiology Astrocytes - metabolism Biological and medical sciences Ca2+ deprivation Calcium - deficiency Calcium‐free medium Caspase 2 Caspases Cell death Cell viability Constitutive proteins Culture Media - chemistry Culture Media - pharmacology Cyclic AMP - metabolism Extracellular Space - metabolism Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Regulation - drug effects Gene Expression Regulation - physiology Isolated neuron and nerve. Neuroglia Mice Neuroglia - metabolism Proteins - genetics Proto-Oncogene Proteins c-fos - metabolism Proto-Oncogene Proteins c-jun - metabolism Proto-Oncogene Proteins c-myc - metabolism Rats RNA, Messenger - metabolism Vertebrates: nervous system and sense organs
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