A dual electrophysiologic test for atrial antireentry and ventricular antifibrillatory studies: Effects of bethanidine, procainamide, and WY-48986

We have developed a dual electrophysiologic test that allows measurement of both antireentry and antifibrillatory activities of potential antiarrhythmics in the same anesthetized dog. The reentry portion of the model was created surgically by a Y-shaped crushing around the tissue between the superio...

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Veröffentlicht in:	Journal of pharmacological methods 1990-04, Vol.23 (2), p.87-95
Hauptverfasser:	Kuei-Meng, Wu, Hunter, Thomas L., Proakis, Anthony G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Arrhythmia Agents - pharmacology Antiarythmic agents Atrial reentry Bethanidine Bethanidine - pharmacology Biological and medical sciences Cardiac Pacing, Artificial Cardiovascular system Dogs Electrocardiography Electrophysiology Female Guanidines - pharmacology Male Medical sciences Myocardium - pathology Pharmacology. Drug treatments Procainamide Procainamide - pharmacology Sulfanilamides Tachycardia, Atrioventricular Nodal Reentry - physiopathology Tachycardia, Supraventricular - physiopathology Ventricular Fibrillation - pathology Ventricular Fibrillation - physiopathology Ventricular fibrillation threshold WY-48986
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