A vacuolar type H(+)-ATPase regulates cytoplasmic pH in murine macrophages

An Na(+)- and HCO3(-)-independent mechanism of cytoplasmic pH (pHi) recovery was previously demonstrated in acid-loaded macrophages (Swallow, C. J., Grinstein, S., and Rotstein, O. D. (1988) J. Biol. Chem. 263, 19558-19563). Acid extrusion was found to be ATP-dependent and sensitive to N-ethylmaleim...

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Veröffentlicht in:	The Journal of biological chemistry 1990-05, Vol.265 (13), p.7645-7654
Hauptverfasser:	SWALLOW, C. J, GRINSTEIN, S, ROTSTEIN, O. D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bicarbonates - pharmacology Calcium - metabolism Cell Membrane - physiology Cells, Cultured Colchicine - pharmacology Egtazic Acid - pharmacology Exact sciences and technology Exocytosis Female Hydrogen-Ion Concentration Ionomycin - pharmacology Kinetics Macrophages - drug effects Macrophages - metabolism Macrophages - physiology Mathematical analysis Mathematics Membrane Potentials Mice Nigericin - pharmacology Potential theory Proton-Translocating ATPases - metabolism Sciences and techniques of general use Sodium - pharmacology Vacuoles - enzymology
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