Type I cAMP-dependent Protein Kinase Delays Apoptosis in Human Neutrophils at a Site Upstream of Caspase-3

Current data suggest that apoptosis controls neutrophil numbers in tissues. We analyzed roles for and the sites of action for the cAMP-dependent protein kinases (cAPKs) in apoptosis induced in human neutrophils by in vitro storage, cycloheximide (CHX) exposure, and anti-Fas exposure. Treatment with...

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Veröffentlicht in:	The Journal of biological chemistry 1998-03, Vol.273 (12), p.6736-6743
Hauptverfasser:	Parvathenani, L K, Buescher, E S, Chacon-Cruz, E, Beebe, S J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Apoptosis - drug effects Calcium - metabolism Caspase 3 Caspases Cells, Cultured Cyclic AMP - analogs & derivatives Cyclic AMP - pharmacology Cyclic AMP-Dependent Protein Kinase Type II Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors Cyclic AMP-Dependent Protein Kinases - metabolism Cycloheximide - pharmacology Cysteine Endopeptidases - metabolism Enzyme Activation Female Humans Male Neutrophils - cytology Neutrophils - drug effects Neutrophils - enzymology Thionucleotides - pharmacology
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