Deleterious Ca-independent NOS activity after oxidative stress in rat striatum

THE aim of this study was to assess whether oxidative stress induces deleterious NOS activity in the central nervous system (CNS). For this purpose, the mitochondrial toxin malonate, which promotes free radical production, was infused into the left striatum of rats. Forty-eight hours after injection...

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Veröffentlicht in:	Neuroreport 1998-02, Vol.9 (3), p.559-563
Hauptverfasser:	Lecanu, Laurent, Margaill, Isabelle, Boughali, Hicham, Cohen-Tenoudji, Bertrand, Boulu, Roger G, Plotkine, Michel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry and metabolism Biological and medical sciences Calcium - physiology Central nervous system Corpus Striatum - enzymology Cyclic N-Oxides Enzyme Inhibitors - pharmacology Free Radical Scavengers - pharmacology Free Radicals Fundamental and applied biological sciences. Psychology Guanidines - pharmacology Male Malonates - pharmacology Necrosis Nitric Oxide Synthase - metabolism Nitrogen Oxides - pharmacology Oxidative Stress - physiology Rats Rats, Sprague-Dawley Vertebrates: nervous system and sense organs
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