Deleterious Ca-independent NOS activity after oxidative stress in rat striatum
THE aim of this study was to assess whether oxidative stress induces deleterious NOS activity in the central nervous system (CNS). For this purpose, the mitochondrial toxin malonate, which promotes free radical production, was infused into the left striatum of rats. Forty-eight hours after injection...
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| Veröffentlicht in: | Neuroreport 1998-02, Vol.9 (3), p.559-563 |
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| creator | Lecanu, Laurent Margaill, Isabelle Boughali, Hicham Cohen-Tenoudji, Bertrand Boulu, Roger G Plotkine, Michel |
| description | THE aim of this study was to assess whether oxidative stress induces deleterious NOS activity in the central nervous system (CNS). For this purpose, the mitochondrial toxin malonate, which promotes free radical production, was infused into the left striatum of rats. Forty-eight hours after injection, an increase in Ca-independent NOS activity was observed in the injected striatum. This increase was blocked by α-phenyl-tertbutyl-nitrone, a free radical scavenger, and by aminoguanidine, an inhibitor of NOS 2. Both these drugs reduced the malonate-induced striatal necrotic volume. These results suggest that in the CNS oxidative stress can induce a Ca-independent NOS, probably of type 2, which contributes to the lesion. |
| doi_str_mv | 10.1097/00001756-199802160-00032 |
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For this purpose, the mitochondrial toxin malonate, which promotes free radical production, was infused into the left striatum of rats. Forty-eight hours after injection, an increase in Ca-independent NOS activity was observed in the injected striatum. This increase was blocked by α-phenyl-tertbutyl-nitrone, a free radical scavenger, and by aminoguanidine, an inhibitor of NOS 2. Both these drugs reduced the malonate-induced striatal necrotic volume. 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Psychology ; Guanidines - pharmacology ; Male ; Malonates - pharmacology ; Necrosis ; Nitric Oxide Synthase - metabolism ; Nitrogen Oxides - pharmacology ; Oxidative Stress - physiology ; Rats ; Rats, Sprague-Dawley ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroreport, 1998-02, Vol.9 (3), p.559-563</ispartof><rights>Lippincott-Raven Publishers.</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4152-e905d301ab7ca6b7f9abdd0a5f8fb72178ff98da565c02eaf9199fc999f296bd3</citedby><cites>FETCH-LOGICAL-c4152-e905d301ab7ca6b7f9abdd0a5f8fb72178ff98da565c02eaf9199fc999f296bd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2152528$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9512406$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lecanu, Laurent</creatorcontrib><creatorcontrib>Margaill, Isabelle</creatorcontrib><creatorcontrib>Boughali, Hicham</creatorcontrib><creatorcontrib>Cohen-Tenoudji, Bertrand</creatorcontrib><creatorcontrib>Boulu, Roger G</creatorcontrib><creatorcontrib>Plotkine, Michel</creatorcontrib><title>Deleterious Ca-independent NOS activity after oxidative stress in rat striatum</title><title>Neuroreport</title><addtitle>Neuroreport</addtitle><description>THE aim of this study was to assess whether oxidative stress induces deleterious NOS activity in the central nervous system (CNS). For this purpose, the mitochondrial toxin malonate, which promotes free radical production, was infused into the left striatum of rats. Forty-eight hours after injection, an increase in Ca-independent NOS activity was observed in the injected striatum. This increase was blocked by α-phenyl-tertbutyl-nitrone, a free radical scavenger, and by aminoguanidine, an inhibitor of NOS 2. Both these drugs reduced the malonate-induced striatal necrotic volume. These results suggest that in the CNS oxidative stress can induce a Ca-independent NOS, probably of type 2, which contributes to the lesion.</description><subject>Animals</subject><subject>Biochemistry and metabolism</subject><subject>Biological and medical sciences</subject><subject>Calcium - physiology</subject><subject>Central nervous system</subject><subject>Corpus Striatum - enzymology</subject><subject>Cyclic N-Oxides</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Free Radical Scavengers - pharmacology</subject><subject>Free Radicals</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Guanidines - pharmacology</subject><subject>Male</subject><subject>Malonates - pharmacology</subject><subject>Necrosis</subject><subject>Nitric Oxide Synthase - metabolism</subject><subject>Nitrogen Oxides - pharmacology</subject><subject>Oxidative Stress - physiology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0959-4965</issn><issn>1473-558X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v3CAQQFHVKtmm_QmROFS9OQVsDByrbdJWipJDEik3NMaDQuK1t4Dz8e_Ldrd7i8JhEMMbYB6EUM5OODPqGyuDK9lW3BjNBG9ZVTK1eEcWvFF1JaW-fU8WzEhTNaaVh-RjSvcFMYzrA3JgJBcNaxfk4gcOmDGGaU50CVUYe1xjCWOmF5dXFFwOjyG_UPCFotNz6KFkkKYcMSUaRhohb1YB8rz6RD54GBJ-3s1H5Obs9Hr5qzq__Pl7-f28cg2XokLDZF8zDp1y0HbKG-j6noH02ndKcKW9N7oH2UrHBII3pU_vTAnCtF1fH5Gv23PXcfozY8p2FZLDYYARSydWGdUwxfWbIG-FFobzAuot6OKUUkRv1zGsIL5YzuzGuf3v3O6d23_OS-nx7o65W2G_L9xJLvtfdvuQHAw-wuhC2mOiGJFi89Rmiz1NQ3GdHob5CaO9QxjynX3tx-u_hRCZfQ</recordid><startdate>19980216</startdate><enddate>19980216</enddate><creator>Lecanu, Laurent</creator><creator>Margaill, Isabelle</creator><creator>Boughali, Hicham</creator><creator>Cohen-Tenoudji, Bertrand</creator><creator>Boulu, Roger G</creator><creator>Plotkine, Michel</creator><general>Lippincott-Raven Publishers</general><general>Lippincott Williams and Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19980216</creationdate><title>Deleterious Ca-independent NOS activity after oxidative stress in rat striatum</title><author>Lecanu, Laurent ; Margaill, Isabelle ; Boughali, Hicham ; Cohen-Tenoudji, Bertrand ; Boulu, Roger G ; Plotkine, Michel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4152-e905d301ab7ca6b7f9abdd0a5f8fb72178ff98da565c02eaf9199fc999f296bd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Animals</topic><topic>Biochemistry and metabolism</topic><topic>Biological and medical sciences</topic><topic>Calcium - physiology</topic><topic>Central nervous system</topic><topic>Corpus Striatum - enzymology</topic><topic>Cyclic N-Oxides</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>Free Radical Scavengers - pharmacology</topic><topic>Free Radicals</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Guanidines - pharmacology</topic><topic>Male</topic><topic>Malonates - pharmacology</topic><topic>Necrosis</topic><topic>Nitric Oxide Synthase - metabolism</topic><topic>Nitrogen Oxides - pharmacology</topic><topic>Oxidative Stress - physiology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lecanu, Laurent</creatorcontrib><creatorcontrib>Margaill, Isabelle</creatorcontrib><creatorcontrib>Boughali, Hicham</creatorcontrib><creatorcontrib>Cohen-Tenoudji, Bertrand</creatorcontrib><creatorcontrib>Boulu, Roger G</creatorcontrib><creatorcontrib>Plotkine, Michel</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroreport</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lecanu, Laurent</au><au>Margaill, Isabelle</au><au>Boughali, Hicham</au><au>Cohen-Tenoudji, Bertrand</au><au>Boulu, Roger G</au><au>Plotkine, Michel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Deleterious Ca-independent NOS activity after oxidative stress in rat striatum</atitle><jtitle>Neuroreport</jtitle><addtitle>Neuroreport</addtitle><date>1998-02-16</date><risdate>1998</risdate><volume>9</volume><issue>3</issue><spage>559</spage><epage>563</epage><pages>559-563</pages><issn>0959-4965</issn><eissn>1473-558X</eissn><abstract>THE aim of this study was to assess whether oxidative stress induces deleterious NOS activity in the central nervous system (CNS). 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| ispartof | Neuroreport, 1998-02, Vol.9 (3), p.559-563 |
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| subjects | Animals Biochemistry and metabolism Biological and medical sciences Calcium - physiology Central nervous system Corpus Striatum - enzymology Cyclic N-Oxides Enzyme Inhibitors - pharmacology Free Radical Scavengers - pharmacology Free Radicals Fundamental and applied biological sciences. Psychology Guanidines - pharmacology Male Malonates - pharmacology Necrosis Nitric Oxide Synthase - metabolism Nitrogen Oxides - pharmacology Oxidative Stress - physiology Rats Rats, Sprague-Dawley Vertebrates: nervous system and sense organs |
| title | Deleterious Ca-independent NOS activity after oxidative stress in rat striatum |
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