Intracellular and extracellular blood magnesium fractions in hemodialysis patients; is the ionized fraction a measure of magnesium excess?
To establish the best measure for determining magnesium overload, we measured ionized and total magnesium in serum and mononuclear blood cells and total magnesium in erythrocytes in blood of 23 hemodialysis patients, known for their disturbed magnesium homeostasis. When comparing the mean magnesium...
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| Veröffentlicht in: | Clinical chemistry (Baltimore, Md.) Md.), 1998-03, Vol.44 (3), p.639-648 |
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| container_title | Clinical chemistry (Baltimore, Md.) |
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| creator | Huijgen, Henk J Sanders, Renata van Olden, Rudolf W Klous, Marjolein G Gaffar, Faryal R Sanders, Gerard T. B |
| description | To establish the best measure for determining magnesium overload, we measured ionized and total magnesium in serum and mononuclear blood cells and total magnesium in erythrocytes in blood of 23 hemodialysis patients, known for their disturbed magnesium homeostasis. When comparing the mean magnesium values obtained in the patient population with those of a control population, all of these magnesium markers, including the biologically active fractions, were significantly (P < 0.05) increased. Because serum total magnesium was not increased in all dialysis patients studied, the population was divided into two groups, according to total serum magnesium > 1.0 mmol/L or less than that. Results in these two populations showed that ionized serum magnesium and ionized magnesium in mononuclear blood cells might give a better indication about the magnesium status of the tested patients than the currently used total serum magnesium data. However, neither of the two markers, especially ionized serum magnesium, was able to discriminate fully between normal magnesium homeostasis and magnesium excess. We therefore conclude that the two ionized magnesium markers offer minimal advantage for this discrimination, and that the total magnesium concentration in serum remains the measurement of choice. |
| doi_str_mv | 10.1093/clinchem/44.3.639 |
| format | Article |
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Results in these two populations showed that ionized serum magnesium and ionized magnesium in mononuclear blood cells might give a better indication about the magnesium status of the tested patients than the currently used total serum magnesium data. However, neither of the two markers, especially ionized serum magnesium, was able to discriminate fully between normal magnesium homeostasis and magnesium excess. We therefore conclude that the two ionized magnesium markers offer minimal advantage for this discrimination, and that the total magnesium concentration in serum remains the measurement of choice.</description><identifier>ISSN: 0009-9147</identifier><identifier>EISSN: 1530-8561</identifier><identifier>DOI: 10.1093/clinchem/44.3.639</identifier><identifier>PMID: 9510873</identifier><identifier>CODEN: CLCHAU</identifier><language>eng</language><publisher>Washington, DC: Am Assoc Clin Chem</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Erythrocytes - chemistry ; Erythrocytes - metabolism ; Female ; Flow Cytometry - methods ; Fluorescent Dyes ; Homeostasis ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Kidney Failure, Chronic - blood ; Kidney Failure, Chronic - therapy ; Lymphocytes - chemistry ; Lymphocytes - metabolism ; Magnesium - blood ; Male ; Medical sciences ; Middle Aged ; Miscellaneous. 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We therefore conclude that the two ionized magnesium markers offer minimal advantage for this discrimination, and that the total magnesium concentration in serum remains the measurement of choice.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Erythrocytes - chemistry</subject><subject>Erythrocytes - metabolism</subject><subject>Female</subject><subject>Flow Cytometry - methods</subject><subject>Fluorescent Dyes</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Kidney Failure, Chronic - blood</subject><subject>Kidney Failure, Chronic - therapy</subject><subject>Lymphocytes - chemistry</subject><subject>Lymphocytes - metabolism</subject><subject>Magnesium - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Miscellaneous. 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When comparing the mean magnesium values obtained in the patient population with those of a control population, all of these magnesium markers, including the biologically active fractions, were significantly (P < 0.05) increased. Because serum total magnesium was not increased in all dialysis patients studied, the population was divided into two groups, according to total serum magnesium > 1.0 mmol/L or less than that. Results in these two populations showed that ionized serum magnesium and ionized magnesium in mononuclear blood cells might give a better indication about the magnesium status of the tested patients than the currently used total serum magnesium data. However, neither of the two markers, especially ionized serum magnesium, was able to discriminate fully between normal magnesium homeostasis and magnesium excess. We therefore conclude that the two ionized magnesium markers offer minimal advantage for this discrimination, and that the total magnesium concentration in serum remains the measurement of choice.</abstract><cop>Washington, DC</cop><pub>Am Assoc Clin Chem</pub><pmid>9510873</pmid><doi>10.1093/clinchem/44.3.639</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Clinical chemistry (Baltimore, Md.), 1998-03, Vol.44 (3), p.639-648 |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Adult Aged Aged, 80 and over Biological and medical sciences Erythrocytes - chemistry Erythrocytes - metabolism Female Flow Cytometry - methods Fluorescent Dyes Homeostasis Humans Investigative techniques, diagnostic techniques (general aspects) Kidney Failure, Chronic - blood Kidney Failure, Chronic - therapy Lymphocytes - chemistry Lymphocytes - metabolism Magnesium - blood Male Medical sciences Middle Aged Miscellaneous. Technology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Reference Values Renal Dialysis Spectrometry, Fluorescence - methods |
| title | Intracellular and extracellular blood magnesium fractions in hemodialysis patients; is the ionized fraction a measure of magnesium excess? |
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