Relaxation of a transfer RNA specificity by removal of modified nucleotides

THE molecular recognition of specific transfer RNAs by the appropriate aminoacyl-tRNA synthetase is an important step in determining the accuracy of translation of the genetic message from nucleic acids into proteins. Recent studies using variant tRNAs with specifie sequence modifications have indic...

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Veröffentlicht in:	Nature (London) 1990-04, Vol.344 (6268), p.787-789
Hauptverfasser:	Perret, Véronique, Garcia, Angela, Grosjean, Henri, Ebel, Jean-Pierre, Florentz, Catherine, Giegé, Richard
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Analytical, structural and metabolic biochemistry Arginine - metabolism Arginine-tRNA Ligase - metabolism Aspartate-tRNA Ligase - metabolism Aspartic Acid - metabolism Base Sequence Biochemistry Biological and medical sciences Conformation DNA-directed RNA polymerase Enzymes Fundamental and applied biological sciences. Psychology Genetics Humanities and Social Sciences Kinetics letter Molecular Sequence Data Molecules multidisciplinary Nucleic Acid Conformation Nucleic acids Nucleotides Pasteur, Louis (1822-95) Phages Proteins Ribonucleic acid RNA RNA phages RNA polymerase RNA, Fungal - genetics RNA, Fungal - metabolism Rna, ribonucleoproteins RNA, Transfer, Amino Acid-Specific - metabolism RNA, Transfer, Arg RNA, Transfer, Asp - genetics RNA, Transfer, Asp - metabolism Science Science (multidisciplinary) Structure-Activity Relationship Transcription, Genetic Transfer RNA tRNA
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