Prospective, randomized, controlled comparison of the use of polyethylene glycol electrolyte lavage solution in four-liter versus two-liter volumes and pretreatment with either magnesium citrate or bisacodyl for colonoscopy preparation
Background: Laxative pretreatment decreases the volume of polyethylene glycol electrolyte lavage solution (PEG-ELS) required for colonoscopy without compromising preparation quality. We compared the use of 4 L of PEG-ELS with the use of 2 L plus a laxative. Methods: One hundred fifty consecutive pat...
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| Veröffentlicht in: | Gastrointestinal endoscopy 1998-02, Vol.47 (2), p.167-171 |
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| creator | Sharma, Virender K. Chockalingham, Siva K. Ugheoke, Eghierhua A. Kapur, Ashok DO, Phillis Ling Vasudeva, Rajeev Howden, Colin W. |
| description | Background: Laxative pretreatment decreases the volume of polyethylene glycol electrolyte lavage solution (PEG-ELS) required for colonoscopy without compromising preparation quality. We compared the use of 4 L of PEG-ELS with the use of 2 L plus a laxative.
Methods: One hundred fifty consecutive patients (148 men) undergoing outpatient colonoscopy were randomly selected for one of three preparations (Prep 1: 4 L PEG-ELS; Prep 2: 2 L PEG-ELS plus 296 mL magnesium citrate 1 hour prior; Prep 3: 2 L PEG-ELS plus bisacodyl 20 mg). Endoscopists were blinded as to the type of preparation.
Results: Colonoscopy times were 37, 33, and 29.5 minutes (
p = 0.02). Satisfaction scores (0 to 11) during preparation were 2.75, 1.84, and 2.54 (
p = 0.05). Preparation times were 519, 397, and 379 minutes (
p < 0.001). Preparation satisfaction scores (0 to 10) were 6.2, 7.7, and 7.4 (
p < 0.001). Endoscopists' scores of preparation quality (1 to 10) were 7.3, 7.8, and 8.1 (
p = 0.03). Volumes of liquid stool aspirated were 181, 103, and 90 mL (
p < 0.001). Twenty-four patients receiving Prep 2 and 16 receiving Prep 3 had previous colonoscopy using full volume PEG-ELS; 88% who received Prep 2 and 56% who received Prep 3 preferred the newer preparation (
p = 0.006).
Conclusions: Two liters of PEG-ELS plus laxative improved preparation quality and patient satisfaction and reduced preparation time. Magnesium citrate pretreatment had fewer symptoms and was preferred to bisacodyl. PEG-ELS in 2 L quantities could reduce costs, and consideration should be given to making it available commercially. (Gastrointest Endosc 1998;47:167-71) |
| doi_str_mv | 10.1016/S0016-5107(98)70351-7 |
| format | Article |
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Methods: One hundred fifty consecutive patients (148 men) undergoing outpatient colonoscopy were randomly selected for one of three preparations (Prep 1: 4 L PEG-ELS; Prep 2: 2 L PEG-ELS plus 296 mL magnesium citrate 1 hour prior; Prep 3: 2 L PEG-ELS plus bisacodyl 20 mg). Endoscopists were blinded as to the type of preparation.
Results: Colonoscopy times were 37, 33, and 29.5 minutes (
p = 0.02). Satisfaction scores (0 to 11) during preparation were 2.75, 1.84, and 2.54 (
p = 0.05). Preparation times were 519, 397, and 379 minutes (
p < 0.001). Preparation satisfaction scores (0 to 10) were 6.2, 7.7, and 7.4 (
p < 0.001). Endoscopists' scores of preparation quality (1 to 10) were 7.3, 7.8, and 8.1 (
p = 0.03). Volumes of liquid stool aspirated were 181, 103, and 90 mL (
p < 0.001). Twenty-four patients receiving Prep 2 and 16 receiving Prep 3 had previous colonoscopy using full volume PEG-ELS; 88% who received Prep 2 and 56% who received Prep 3 preferred the newer preparation (
p = 0.006).
Conclusions: Two liters of PEG-ELS plus laxative improved preparation quality and patient satisfaction and reduced preparation time. Magnesium citrate pretreatment had fewer symptoms and was preferred to bisacodyl. PEG-ELS in 2 L quantities could reduce costs, and consideration should be given to making it available commercially. (Gastrointest Endosc 1998;47:167-71)</description><identifier>ISSN: 0016-5107</identifier><identifier>EISSN: 1097-6779</identifier><identifier>DOI: 10.1016/S0016-5107(98)70351-7</identifier><identifier>PMID: 9512283</identifier><identifier>CODEN: GAENBQ</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Bisacodyl - administration & dosage ; Cathartics - administration & dosage ; Citric Acid - administration & dosage ; Colonoscopy ; Digestive system ; Female ; Gastric Lavage - methods ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Medical sciences ; Middle Aged ; Organometallic Compounds - administration & dosage ; Polyethylene Glycols - administration & dosage ; Prospective Studies ; Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><ispartof>Gastrointestinal endoscopy, 1998-02, Vol.47 (2), p.167-171</ispartof><rights>1998 American Society for Gastrointestinal Endoscopy</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-5893aff64bf66070aa81f74436c21893af28d9c13c47c4950e70ede2f2f6c5213</citedby><cites>FETCH-LOGICAL-c389t-5893aff64bf66070aa81f74436c21893af28d9c13c47c4950e70ede2f2f6c5213</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0016510798703517$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,776,780,785,786,3537,23909,23910,25118,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2160114$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9512283$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sharma, Virender K.</creatorcontrib><creatorcontrib>Chockalingham, Siva K.</creatorcontrib><creatorcontrib>Ugheoke, Eghierhua A.</creatorcontrib><creatorcontrib>Kapur, Ashok</creatorcontrib><creatorcontrib>DO, Phillis Ling</creatorcontrib><creatorcontrib>Vasudeva, Rajeev</creatorcontrib><creatorcontrib>Howden, Colin W.</creatorcontrib><title>Prospective, randomized, controlled comparison of the use of polyethylene glycol electrolyte lavage solution in four-liter versus two-liter volumes and pretreatment with either magnesium citrate or bisacodyl for colonoscopy preparation</title><title>Gastrointestinal endoscopy</title><addtitle>Gastrointest Endosc</addtitle><description>Background: Laxative pretreatment decreases the volume of polyethylene glycol electrolyte lavage solution (PEG-ELS) required for colonoscopy without compromising preparation quality. We compared the use of 4 L of PEG-ELS with the use of 2 L plus a laxative.
Methods: One hundred fifty consecutive patients (148 men) undergoing outpatient colonoscopy were randomly selected for one of three preparations (Prep 1: 4 L PEG-ELS; Prep 2: 2 L PEG-ELS plus 296 mL magnesium citrate 1 hour prior; Prep 3: 2 L PEG-ELS plus bisacodyl 20 mg). Endoscopists were blinded as to the type of preparation.
Results: Colonoscopy times were 37, 33, and 29.5 minutes (
p = 0.02). Satisfaction scores (0 to 11) during preparation were 2.75, 1.84, and 2.54 (
p = 0.05). Preparation times were 519, 397, and 379 minutes (
p < 0.001). Preparation satisfaction scores (0 to 10) were 6.2, 7.7, and 7.4 (
p < 0.001). Endoscopists' scores of preparation quality (1 to 10) were 7.3, 7.8, and 8.1 (
p = 0.03). Volumes of liquid stool aspirated were 181, 103, and 90 mL (
p < 0.001). Twenty-four patients receiving Prep 2 and 16 receiving Prep 3 had previous colonoscopy using full volume PEG-ELS; 88% who received Prep 2 and 56% who received Prep 3 preferred the newer preparation (
p = 0.006).
Conclusions: Two liters of PEG-ELS plus laxative improved preparation quality and patient satisfaction and reduced preparation time. Magnesium citrate pretreatment had fewer symptoms and was preferred to bisacodyl. PEG-ELS in 2 L quantities could reduce costs, and consideration should be given to making it available commercially. (Gastrointest Endosc 1998;47:167-71)</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Bisacodyl - administration & dosage</subject><subject>Cathartics - administration & dosage</subject><subject>Citric Acid - administration & dosage</subject><subject>Colonoscopy</subject><subject>Digestive system</subject><subject>Female</subject><subject>Gastric Lavage - methods</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Organometallic Compounds - administration & dosage</subject><subject>Polyethylene Glycols - administration & dosage</subject><subject>Prospective Studies</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><issn>0016-5107</issn><issn>1097-6779</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkd2KFDEQhRtR1nH1ERZyIaKwrUn_pXMlsrirsKCgXodMujITSSdtkp6lfWVfwpof59abSkidOnXIVxRXjL5llHXvvlGsZcsofy36N5zWLSv5o2LFqOBlx7l4XKzOkqfFs5R-Ukr7qmYXxYVoWVX19ar48zWGNIHOdgfXJCo_hNH-huGa6OBzDM7BgNdxUtGm4EkwJG-BzAn21ym4BfJ2ceCBbNyigyPg0A0HlwzEqZ3aAEnBzdnitPXEhDmWzmaIZAcxzYnkh_DvAXUjJIIpyBQhR1B5BJ_Jg81bAlhQNKqNh2TnkWibo8ItIZK1TUqHYXHoHzGvCz4kHaZl74PZ1X798-KJUS7Bi9N5Wfy4_fj95lN5_-Xu882H-1LXvchl24taGdM1a9N1lFOlemZ409SdrtihV_WD0KzWDdeNaClwCgNUpjKdbitWXxavjr5TDL9mSFmONmlwTnkIc5Jc8FpUbYvC9ijUCCFFMHKKdlRxkYzKPWR5gCz3BKXo5QGy5Dh3dVowr0cYzlMnqth_eeqrpJUziFXbdJZVrKOMNSh7f5QBfsbOQpRJW_AaBhuRoRyC_U-Qv6-wzA0</recordid><startdate>19980201</startdate><enddate>19980201</enddate><creator>Sharma, Virender K.</creator><creator>Chockalingham, Siva K.</creator><creator>Ugheoke, Eghierhua A.</creator><creator>Kapur, Ashok</creator><creator>DO, Phillis Ling</creator><creator>Vasudeva, Rajeev</creator><creator>Howden, Colin W.</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19980201</creationdate><title>Prospective, randomized, controlled comparison of the use of polyethylene glycol electrolyte lavage solution in four-liter versus two-liter volumes and pretreatment with either magnesium citrate or bisacodyl for colonoscopy preparation</title><author>Sharma, Virender K. ; Chockalingham, Siva K. ; Ugheoke, Eghierhua A. ; Kapur, Ashok ; DO, Phillis Ling ; Vasudeva, Rajeev ; Howden, Colin W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-5893aff64bf66070aa81f74436c21893af28d9c13c47c4950e70ede2f2f6c5213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Bisacodyl - administration & dosage</topic><topic>Cathartics - administration & dosage</topic><topic>Citric Acid - administration & dosage</topic><topic>Colonoscopy</topic><topic>Digestive system</topic><topic>Female</topic><topic>Gastric Lavage - methods</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Organometallic Compounds - administration & dosage</topic><topic>Polyethylene Glycols - administration & dosage</topic><topic>Prospective Studies</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sharma, Virender K.</creatorcontrib><creatorcontrib>Chockalingham, Siva K.</creatorcontrib><creatorcontrib>Ugheoke, Eghierhua A.</creatorcontrib><creatorcontrib>Kapur, Ashok</creatorcontrib><creatorcontrib>DO, Phillis Ling</creatorcontrib><creatorcontrib>Vasudeva, Rajeev</creatorcontrib><creatorcontrib>Howden, Colin W.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Gastrointestinal endoscopy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sharma, Virender K.</au><au>Chockalingham, Siva K.</au><au>Ugheoke, Eghierhua A.</au><au>Kapur, Ashok</au><au>DO, Phillis Ling</au><au>Vasudeva, Rajeev</au><au>Howden, Colin W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prospective, randomized, controlled comparison of the use of polyethylene glycol electrolyte lavage solution in four-liter versus two-liter volumes and pretreatment with either magnesium citrate or bisacodyl for colonoscopy preparation</atitle><jtitle>Gastrointestinal endoscopy</jtitle><addtitle>Gastrointest Endosc</addtitle><date>1998-02-01</date><risdate>1998</risdate><volume>47</volume><issue>2</issue><spage>167</spage><epage>171</epage><pages>167-171</pages><issn>0016-5107</issn><eissn>1097-6779</eissn><coden>GAENBQ</coden><abstract>Background: Laxative pretreatment decreases the volume of polyethylene glycol electrolyte lavage solution (PEG-ELS) required for colonoscopy without compromising preparation quality. We compared the use of 4 L of PEG-ELS with the use of 2 L plus a laxative.
Methods: One hundred fifty consecutive patients (148 men) undergoing outpatient colonoscopy were randomly selected for one of three preparations (Prep 1: 4 L PEG-ELS; Prep 2: 2 L PEG-ELS plus 296 mL magnesium citrate 1 hour prior; Prep 3: 2 L PEG-ELS plus bisacodyl 20 mg). Endoscopists were blinded as to the type of preparation.
Results: Colonoscopy times were 37, 33, and 29.5 minutes (
p = 0.02). Satisfaction scores (0 to 11) during preparation were 2.75, 1.84, and 2.54 (
p = 0.05). Preparation times were 519, 397, and 379 minutes (
p < 0.001). Preparation satisfaction scores (0 to 10) were 6.2, 7.7, and 7.4 (
p < 0.001). Endoscopists' scores of preparation quality (1 to 10) were 7.3, 7.8, and 8.1 (
p = 0.03). Volumes of liquid stool aspirated were 181, 103, and 90 mL (
p < 0.001). Twenty-four patients receiving Prep 2 and 16 receiving Prep 3 had previous colonoscopy using full volume PEG-ELS; 88% who received Prep 2 and 56% who received Prep 3 preferred the newer preparation (
p = 0.006).
Conclusions: Two liters of PEG-ELS plus laxative improved preparation quality and patient satisfaction and reduced preparation time. Magnesium citrate pretreatment had fewer symptoms and was preferred to bisacodyl. PEG-ELS in 2 L quantities could reduce costs, and consideration should be given to making it available commercially. (Gastrointest Endosc 1998;47:167-71)</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>9512283</pmid><doi>10.1016/S0016-5107(98)70351-7</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Aged Aged, 80 and over Biological and medical sciences Bisacodyl - administration & dosage Cathartics - administration & dosage Citric Acid - administration & dosage Colonoscopy Digestive system Female Gastric Lavage - methods Humans Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Middle Aged Organometallic Compounds - administration & dosage Polyethylene Glycols - administration & dosage Prospective Studies Radiodiagnosis. Nmr imagery. Nmr spectrometry |
| title | Prospective, randomized, controlled comparison of the use of polyethylene glycol electrolyte lavage solution in four-liter versus two-liter volumes and pretreatment with either magnesium citrate or bisacodyl for colonoscopy preparation |
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