Animal pharmacokinetics of inogatran, a low-molecular-weight thrombin inhibitor with potential use as an antithrombotic drug

Pharmacokinetics, excretion, and metabolism of inogatran, a low‐molecular‐weight thrombin inhibitor, were studied in the rat, dog, and cynomolgus monkey. After intravenous administration the half‐life was short in all three animal species, due to a small volume of distribution and a relatively high...

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Veröffentlicht in:	Biopharmaceutics & drug disposition 1998-01, Vol.19 (1), p.55-64
Hauptverfasser:	Eriksson, Ulf G., Renberg, Lars, Bredberg, Ulf, Teger-Nilsson, Ann-Catrine, Gunnar Regårdh, Carl
Format:	Artikel
Sprache:	eng
Schlagworte:	animal pharmacokinetics Animals Antithrombins - pharmacology Area Under Curve Biological and medical sciences Biotransformation Blood Proteins - metabolism Blood. Blood coagulation. Reticuloendothelial system Dogs Female Glycine - analogs & derivatives Glycine - pharmacokinetics Glycine - pharmacology Half-Life Humans inogatran Macaca fascicularis Male Medical sciences Molecular Weight Pharmacology. Drug treatments Piperidines - pharmacokinetics Piperidines - pharmacology Rats Rats, Sprague-Dawley Species Specificity thrombin inhibitor
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