Separation of Paclitaxel and Related Taxanes by Micellar Electrokinetic Capillary Chromatography

Micellar electrokinetic capillary chromatography is used to separate paclitaxel (trade name Taxol, Bristol-Myers Squibb) and 14 related taxanes in 11.5 min. An aqueous acetonitrile (ACN) buffer containing sodium dodecyl sulfate (SDS) surfactant allows resolution of the 15 taxanes from each other and...

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Veröffentlicht in:	Analytical chemistry (Washington) 1998-03, Vol.70 (5), p.897-906
Hauptverfasser:	Shao, Lillian Kuangjing, Locke, David C
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetonitriles Analysis Biological and medical sciences Chemistry Chromatography - methods Drugs General pharmacology Glycerol - analogs & derivatives Medical sciences Micelles Paclitaxel - analogs & derivatives Paclitaxel - isolation & purification Pharmacology Pharmacology. Drug treatments Plant Extracts - analysis Sodium Dodecyl Sulfate Temperature Thermodynamics
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