Requirements of Focal Adhesions and Calcium Fluxes for Interleukin-1-induced ERK Kinase Activation and c-fos Expression in Fibroblasts

Interleukin-1 (IL-1) is an important inflammatory mediator and plays a central role in the destruction of connective tissue matrices in diseases such as arthritis and periodontitis. It is well established that IL-1 activation of the mitogen-activated protein (MAP) kinase pathway and induction of c-...

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Veröffentlicht in:	The Journal of biological chemistry 1998-03, Vol.273 (12), p.7059-7065
Hauptverfasser:	Lo, Y Y, Luo, L, McCulloch, C A, Cruz, T F
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood Calcium - metabolism Calcium-Calmodulin-Dependent Protein Kinases - metabolism Cell Adhesion Cells, Cultured Enzyme Activation Fibroblasts - cytology Fibroblasts - metabolism Gene Expression Regulation Genes, fos Humans Interleukin-1 - pharmacology Ion Transport
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