Effect of Viscous Indigestible Polysaccharides on Pancreatic-Biliary Secretion and Digestive Organs in Rats
Effects of viscous indigestible polysaccharides on the pancreas exocrine function were investigated in growing rats. Rats were fed a nonfiber diet or a diet containing approximately 5% of one of the following fibers: apple pectin, λ-carrageenan, locust bean gum, gum xanthan, guar gum or sodium (Na)...
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| Veröffentlicht in: | The Journal of nutrition 1990-04, Vol.120 (4), p.353-360 |
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| creator | Ikegami, Sachie Tsuchihashi, Fumie Harada, Hironobu Tsuchihashi, Noboru Nishide, Eiichi Innami, Satoshi |
| description | Effects of viscous indigestible polysaccharides on the pancreas exocrine function were investigated in growing rats. Rats were fed a nonfiber diet or a diet containing approximately 5% of one of the following fibers: apple pectin, λ-carrageenan, locust bean gum, gum xanthan, guar gum or sodium (Na) alginate. Pancreatic-bile secretion was found to be elevated in rats fed for 2 wk the highly viscous polysaccharides, sodium alginate, locust bean gum, gum xanthan and guar gum. The polysaccharides may have interfered with the digestion and absorption of nutrients, resulting in a decreased digestibility and an enlargement of digestive organs. When alginic acid and calcium alginate, insoluble polysaccharides that did not contribute to viscosity, were given to rats, they had no effect on pancreatic and biliary secretion compared with sodium alginate. The results demonstrate that consumption of viscous indigestible polysaccharides leads to changes in the exocrine pancreatic-biliary function and may depress the process of digestion and absorption. Rats may compensate for the inefficiency of digestion and absorption with a hyperplasia/hypertrophy of digestive organs and an increased secretion of digestive juice. |
| doi_str_mv | 10.1093/jn/120.4.353 |
| format | Article |
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Rats were fed a nonfiber diet or a diet containing approximately 5% of one of the following fibers: apple pectin, λ-carrageenan, locust bean gum, gum xanthan, guar gum or sodium (Na) alginate. Pancreatic-bile secretion was found to be elevated in rats fed for 2 wk the highly viscous polysaccharides, sodium alginate, locust bean gum, gum xanthan and guar gum. The polysaccharides may have interfered with the digestion and absorption of nutrients, resulting in a decreased digestibility and an enlargement of digestive organs. When alginic acid and calcium alginate, insoluble polysaccharides that did not contribute to viscosity, were given to rats, they had no effect on pancreatic and biliary secretion compared with sodium alginate. The results demonstrate that consumption of viscous indigestible polysaccharides leads to changes in the exocrine pancreatic-biliary function and may depress the process of digestion and absorption. Rats may compensate for the inefficiency of digestion and absorption with a hyperplasia/hypertrophy of digestive organs and an increased secretion of digestive juice.</description><identifier>ISSN: 0022-3166</identifier><identifier>EISSN: 1541-6100</identifier><identifier>DOI: 10.1093/jn/120.4.353</identifier><identifier>PMID: 2158535</identifier><identifier>CODEN: JONUAI</identifier><language>eng</language><publisher>Bethesda, MD: Elsevier Inc</publisher><subject>ALGINATE ; Alginates - pharmacology ; ALGINATOS ; Animals ; APPAREIL DIGESTIF ; BILE ; Bile Acids and Salts - analysis ; bile secretion ; Biliary Tract - drug effects ; Biliary Tract - secretion ; BILIS ; Biological and medical sciences ; Body Weight ; CARRAGENINAS ; CARRAGHENANE ; CERATONIA SILIQUA ; CYAMOPSIS PSORALIOIDES ; DIETA ; Dietary Carbohydrates - pharmacology ; Dietary Fiber - pharmacology ; Enzymes - analysis ; Fundamental and applied biological sciences. Psychology ; General aspects ; Glucuronic Acid ; GOMA XANTAN ; GOMAS ; GOMME ; guar gum ; Hexuronic Acids ; Intestines - anatomy & histology ; Intestines - drug effects ; Intestines - metabolism ; Male ; Nucleic Acids - analysis ; Organ Size ; Pancreas - anatomy & histology ; Pancreas - drug effects ; Pancreas - secretion ; PECTINAS ; PECTINE ; Polysaccharides - pharmacology ; Proteins - analysis ; RAT ; RATA ; Rats ; Rats, Inbred Strains ; REGIME ALIMENTAIRE ; SECRECION ; SECRETION ; SISTEMA DIGESTIVO ; sodium alginate ; Stomach - drug effects ; Stomach - metabolism ; Vertebrates: digestive system ; Viscosity ; viscous indigestible polysaccharides ; XANTHANE</subject><ispartof>The Journal of nutrition, 1990-04, Vol.120 (4), p.353-360</ispartof><rights>1990 American Society for Nutrition.</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c486t-165ae28910cde968662c1834b14d0ff86f6e8864c4ec329e381a6b4b9f1f2e073</citedby><cites>FETCH-LOGICAL-c486t-165ae28910cde968662c1834b14d0ff86f6e8864c4ec329e381a6b4b9f1f2e073</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19797386$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2158535$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ikegami, Sachie</creatorcontrib><creatorcontrib>Tsuchihashi, Fumie</creatorcontrib><creatorcontrib>Harada, Hironobu</creatorcontrib><creatorcontrib>Tsuchihashi, Noboru</creatorcontrib><creatorcontrib>Nishide, Eiichi</creatorcontrib><creatorcontrib>Innami, Satoshi</creatorcontrib><title>Effect of Viscous Indigestible Polysaccharides on Pancreatic-Biliary Secretion and Digestive Organs in Rats</title><title>The Journal of nutrition</title><addtitle>J Nutr</addtitle><description>Effects of viscous indigestible polysaccharides on the pancreas exocrine function were investigated in growing rats. Rats were fed a nonfiber diet or a diet containing approximately 5% of one of the following fibers: apple pectin, λ-carrageenan, locust bean gum, gum xanthan, guar gum or sodium (Na) alginate. Pancreatic-bile secretion was found to be elevated in rats fed for 2 wk the highly viscous polysaccharides, sodium alginate, locust bean gum, gum xanthan and guar gum. The polysaccharides may have interfered with the digestion and absorption of nutrients, resulting in a decreased digestibility and an enlargement of digestive organs. When alginic acid and calcium alginate, insoluble polysaccharides that did not contribute to viscosity, were given to rats, they had no effect on pancreatic and biliary secretion compared with sodium alginate. The results demonstrate that consumption of viscous indigestible polysaccharides leads to changes in the exocrine pancreatic-biliary function and may depress the process of digestion and absorption. Rats may compensate for the inefficiency of digestion and absorption with a hyperplasia/hypertrophy of digestive organs and an increased secretion of digestive juice.</description><subject>ALGINATE</subject><subject>Alginates - pharmacology</subject><subject>ALGINATOS</subject><subject>Animals</subject><subject>APPAREIL DIGESTIF</subject><subject>BILE</subject><subject>Bile Acids and Salts - analysis</subject><subject>bile secretion</subject><subject>Biliary Tract - drug effects</subject><subject>Biliary Tract - secretion</subject><subject>BILIS</subject><subject>Biological and medical sciences</subject><subject>Body Weight</subject><subject>CARRAGENINAS</subject><subject>CARRAGHENANE</subject><subject>CERATONIA SILIQUA</subject><subject>CYAMOPSIS PSORALIOIDES</subject><subject>DIETA</subject><subject>Dietary Carbohydrates - pharmacology</subject><subject>Dietary Fiber - pharmacology</subject><subject>Enzymes - analysis</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General aspects</subject><subject>Glucuronic Acid</subject><subject>GOMA XANTAN</subject><subject>GOMAS</subject><subject>GOMME</subject><subject>guar gum</subject><subject>Hexuronic Acids</subject><subject>Intestines - anatomy & histology</subject><subject>Intestines - drug effects</subject><subject>Intestines - metabolism</subject><subject>Male</subject><subject>Nucleic Acids - analysis</subject><subject>Organ Size</subject><subject>Pancreas - anatomy & histology</subject><subject>Pancreas - drug effects</subject><subject>Pancreas - secretion</subject><subject>PECTINAS</subject><subject>PECTINE</subject><subject>Polysaccharides - pharmacology</subject><subject>Proteins - analysis</subject><subject>RAT</subject><subject>RATA</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>REGIME ALIMENTAIRE</subject><subject>SECRECION</subject><subject>SECRETION</subject><subject>SISTEMA DIGESTIVO</subject><subject>sodium alginate</subject><subject>Stomach - drug effects</subject><subject>Stomach - metabolism</subject><subject>Vertebrates: digestive system</subject><subject>Viscosity</subject><subject>viscous indigestible polysaccharides</subject><subject>XANTHANE</subject><issn>0022-3166</issn><issn>1541-6100</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkc1PGzEUxK2qKA3QG6dKlXyBExvstdexj-U7EhKINFwtr_c5dbrxUnuDxH-P043gwsmSZ_zezM8IHVEyoUSxs1U4oyWZ8Amr2Bc0phWnhaCEfEVjQsqyYFSIb2g_pRUhhHIlR2hU0kpWrBqjv1fOge1x5_CTT7bbJDwLjV9C6n3dAn7o2tdkrP1jom8g4S7gBxNsBNN7W5z71pv4iueQb3qfRRMafDk8fwF8H5cmJOwDfjR9OkR7zrQJvu_OA7S4vvp9cVvc3d_MLn7dFZZL0RdUVAZKqSixDSghhSgtlYzXlDfEOSmcACkFtxwsKxUwSY2oea0cdSWQKTtAJ8Pc59j92-Qoep2rQduaALmgnqopmyohsvF0MNrYpRTB6efo17mQpkRv2epV0Jmt5jqzzfafu7mbeg3Nu3kHM-vHO90ka1oXMyifPmaq7WK5Xftj8DnTabOM2bOYK8JU9T-TGETIhF48RJ2sh2Ch8TF_lG46_3m6NydmnHg</recordid><startdate>19900401</startdate><enddate>19900401</enddate><creator>Ikegami, Sachie</creator><creator>Tsuchihashi, Fumie</creator><creator>Harada, Hironobu</creator><creator>Tsuchihashi, Noboru</creator><creator>Nishide, Eiichi</creator><creator>Innami, Satoshi</creator><general>Elsevier Inc</general><general>American Society for Nutritional Sciences</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19900401</creationdate><title>Effect of Viscous Indigestible Polysaccharides on Pancreatic-Biliary Secretion and Digestive Organs in Rats</title><author>Ikegami, Sachie ; Tsuchihashi, Fumie ; Harada, Hironobu ; Tsuchihashi, Noboru ; Nishide, Eiichi ; Innami, Satoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c486t-165ae28910cde968662c1834b14d0ff86f6e8864c4ec329e381a6b4b9f1f2e073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>ALGINATE</topic><topic>Alginates - pharmacology</topic><topic>ALGINATOS</topic><topic>Animals</topic><topic>APPAREIL DIGESTIF</topic><topic>BILE</topic><topic>Bile Acids and Salts - analysis</topic><topic>bile secretion</topic><topic>Biliary Tract - drug effects</topic><topic>Biliary Tract - secretion</topic><topic>BILIS</topic><topic>Biological and medical sciences</topic><topic>Body Weight</topic><topic>CARRAGENINAS</topic><topic>CARRAGHENANE</topic><topic>CERATONIA SILIQUA</topic><topic>CYAMOPSIS PSORALIOIDES</topic><topic>DIETA</topic><topic>Dietary Carbohydrates - pharmacology</topic><topic>Dietary Fiber - pharmacology</topic><topic>Enzymes - analysis</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General aspects</topic><topic>Glucuronic Acid</topic><topic>GOMA XANTAN</topic><topic>GOMAS</topic><topic>GOMME</topic><topic>guar gum</topic><topic>Hexuronic Acids</topic><topic>Intestines - anatomy & histology</topic><topic>Intestines - drug effects</topic><topic>Intestines - metabolism</topic><topic>Male</topic><topic>Nucleic Acids - analysis</topic><topic>Organ Size</topic><topic>Pancreas - anatomy & histology</topic><topic>Pancreas - drug effects</topic><topic>Pancreas - secretion</topic><topic>PECTINAS</topic><topic>PECTINE</topic><topic>Polysaccharides - pharmacology</topic><topic>Proteins - analysis</topic><topic>RAT</topic><topic>RATA</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>REGIME ALIMENTAIRE</topic><topic>SECRECION</topic><topic>SECRETION</topic><topic>SISTEMA DIGESTIVO</topic><topic>sodium alginate</topic><topic>Stomach - drug effects</topic><topic>Stomach - metabolism</topic><topic>Vertebrates: digestive system</topic><topic>Viscosity</topic><topic>viscous indigestible polysaccharides</topic><topic>XANTHANE</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ikegami, Sachie</creatorcontrib><creatorcontrib>Tsuchihashi, Fumie</creatorcontrib><creatorcontrib>Harada, Hironobu</creatorcontrib><creatorcontrib>Tsuchihashi, Noboru</creatorcontrib><creatorcontrib>Nishide, Eiichi</creatorcontrib><creatorcontrib>Innami, Satoshi</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ikegami, Sachie</au><au>Tsuchihashi, Fumie</au><au>Harada, Hironobu</au><au>Tsuchihashi, Noboru</au><au>Nishide, Eiichi</au><au>Innami, Satoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Viscous Indigestible Polysaccharides on Pancreatic-Biliary Secretion and Digestive Organs in Rats</atitle><jtitle>The Journal of nutrition</jtitle><addtitle>J Nutr</addtitle><date>1990-04-01</date><risdate>1990</risdate><volume>120</volume><issue>4</issue><spage>353</spage><epage>360</epage><pages>353-360</pages><issn>0022-3166</issn><eissn>1541-6100</eissn><coden>JONUAI</coden><abstract>Effects of viscous indigestible polysaccharides on the pancreas exocrine function were investigated in growing rats. Rats were fed a nonfiber diet or a diet containing approximately 5% of one of the following fibers: apple pectin, λ-carrageenan, locust bean gum, gum xanthan, guar gum or sodium (Na) alginate. Pancreatic-bile secretion was found to be elevated in rats fed for 2 wk the highly viscous polysaccharides, sodium alginate, locust bean gum, gum xanthan and guar gum. The polysaccharides may have interfered with the digestion and absorption of nutrients, resulting in a decreased digestibility and an enlargement of digestive organs. When alginic acid and calcium alginate, insoluble polysaccharides that did not contribute to viscosity, were given to rats, they had no effect on pancreatic and biliary secretion compared with sodium alginate. The results demonstrate that consumption of viscous indigestible polysaccharides leads to changes in the exocrine pancreatic-biliary function and may depress the process of digestion and absorption. Rats may compensate for the inefficiency of digestion and absorption with a hyperplasia/hypertrophy of digestive organs and an increased secretion of digestive juice.</abstract><cop>Bethesda, MD</cop><pub>Elsevier Inc</pub><pmid>2158535</pmid><doi>10.1093/jn/120.4.353</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of nutrition, 1990-04, Vol.120 (4), p.353-360 |
| issn | 0022-3166 1541-6100 |
| language | eng |
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| subjects | ALGINATE Alginates - pharmacology ALGINATOS Animals APPAREIL DIGESTIF BILE Bile Acids and Salts - analysis bile secretion Biliary Tract - drug effects Biliary Tract - secretion BILIS Biological and medical sciences Body Weight CARRAGENINAS CARRAGHENANE CERATONIA SILIQUA CYAMOPSIS PSORALIOIDES DIETA Dietary Carbohydrates - pharmacology Dietary Fiber - pharmacology Enzymes - analysis Fundamental and applied biological sciences. Psychology General aspects Glucuronic Acid GOMA XANTAN GOMAS GOMME guar gum Hexuronic Acids Intestines - anatomy & histology Intestines - drug effects Intestines - metabolism Male Nucleic Acids - analysis Organ Size Pancreas - anatomy & histology Pancreas - drug effects Pancreas - secretion PECTINAS PECTINE Polysaccharides - pharmacology Proteins - analysis RAT RATA Rats Rats, Inbred Strains REGIME ALIMENTAIRE SECRECION SECRETION SISTEMA DIGESTIVO sodium alginate Stomach - drug effects Stomach - metabolism Vertebrates: digestive system Viscosity viscous indigestible polysaccharides XANTHANE |
| title | Effect of Viscous Indigestible Polysaccharides on Pancreatic-Biliary Secretion and Digestive Organs in Rats |
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