Delineation of Selective Influences Shaping the Mutated Expressed Human Ig Heavy Chain Repertoire

After Ag exposure, somatic hypermutation and subsequent selection play significant roles in shaping the peripheral B cell repertoire. However, the disparate impact of each process has not been completely delineated. To address this, the mutational patterns of a large panel of productive V(H)DJ(H) re...

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Veröffentlicht in:	The Journal of immunology (1950) 1998-03, Vol.160 (6), p.2831-2841
Hauptverfasser:	Dorner, Thomas, Brezinschek, Hans-Peter, Foster, Sandra J, Brezinschek, Ruth I, Farner, Nancy L, Lipsky, Peter E
Format:	Artikel
Sprache:	eng
Schlagworte:	Codon Gene Rearrangement Humans Immunoglobulin Heavy Chains - genetics Immunoglobulin Variable Region - genetics Male Middle Aged Mutation
Online-Zugang:	Volltext
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