Distribution and Clearance of Cocaine in Brain Is Influenced by Genetics

The purpose of this study was to examine the pharmacokinetics of cocaine in two inbred mouse strains, C57BL/6 (B6) and DBA/2 (D2). Male and female mice were administered 30 mg kg −1 cocaine IP and killed after 5, 15, 30, or 60 minutes postinjection. Brains were removed quickly and assayed for total...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Pharmacology, biochemistry and behavior biochemistry and behavior, 1998-03, Vol.59 (3), p.637-640
Hauptverfasser:	Azar, Marc R, Acar, Nuket, Erwin, V.Gene, Barbato, Guy F, Morse, Andrew C, Heist, Carrie L, Jones, Byron C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Brain - metabolism Brain Chemistry - genetics Cocaine Cocaine - pharmacokinetics Dopamine Uptake Inhibitors - pharmacokinetics Drug addictions Female Half-Life Inbred strains Male Medical sciences Mice Mice, Inbred C57BL Mice, Inbred DBA Pharmacokinetics Toxicology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!