Functional co-expression of CYP2D6 and human NADPH-cytochrome P450 reductase in escherichia coli

The polymorphic human CYP2D6 has been co-expressed with human NADPH-cytochrome P450 oxidoreductase in Escherichia coli in order to generate a functional recombinant monooxygenase system for the study of xenobiotic metabolism. The two cDNAs were co-expressed from separate, compatible plasmids with di...

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Veröffentlicht in:	Pharmacogenetics (London) 1998-02, Vol.8 (1), p.33-42
Hauptverfasser:	PRITCHARD, M. P, GLANCEY, M. J, BLAKE, J. A. R, GILHAM, D. E, BURCHELL, B, WOLL, C. R, FRIEDBERG, T
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic beta-Antagonists - metabolism Base Sequence Biological and medical sciences Classical genetics, quantitative genetics, hybrids Cytochrome P-450 CYP2D6 - genetics Cytochrome P-450 CYP2D6 - metabolism DNA Primers - genetics Escherichia coli - genetics Ethanolamines - metabolism Fundamental and applied biological sciences. Psychology Gene Expression General pharmacology Genetics of eukaryotes. Biological and molecular evolution Human Humans In Vitro Techniques Kinetics Medical sciences Metoprolol - metabolism NADPH-Ferrihemoprotein Reductase - genetics NADPH-Ferrihemoprotein Reductase - metabolism Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments Plasmids - genetics Polymorphism, Genetic Recombinant Proteins - genetics Recombinant Proteins - metabolism
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