Naltrexone attenuates self-injurious behavior in mentally retarded subjects

The effect of naltrexone on the frequency of self-injurious behavior (SIB) was investigated in 6 male subjects with profound mental retardation. Following a double-blind placebo-controlled crossover design, naltrexone was administered in a dose of 50 mg once daily for 3 consecutive weeks. In 2 of 5...

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Veröffentlicht in:	Biological psychiatry (1969) 1990-04, Vol.27 (7), p.741-746
Hauptverfasser:	Kars, H., Broekema, W., Glaudemans-van Gelderen, I., Verhoeven, W.M.A., van Ree, J.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adolescent Adult Analgesics Biological and medical sciences Brain - drug effects Clinical Trials as Topic Double-Blind Method Down Syndrome - drug therapy Humans Institutionalization Intellectual Disability - drug therapy Intellectual Disability - psychology Male Medical sciences Naltrexone - therapeutic use Neuropharmacology Pharmacology. Drug treatments Receptors, Opioid - drug effects Self Mutilation - drug therapy Self Mutilation - psychology
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