Alterations in antibody-dependent cellular cytotoxicity during the course of HIV-1 infection. Humoral and cellular defects

HIV-1-specific cell-mediated cytotoxicity (CMC) is a form of antibody-dependent cellular cytotoxicity (ADCC) in which HIV-1-specific antibodies arm NK cells directly to become cytotoxic for targets bearing HIV-1 antigenic determinants. This non-MHC-restricted cytotoxic activity is present in early s...

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Bibliographische Detailangaben
Veröffentlicht in:	The Journal of immunology (1950) 1990-05, Vol.144 (9), p.3375-3384
Hauptverfasser:	Tyler, DS, Stanley, SD, Nastala, CA, Austin, AA, Bartlett, JA, Stine, KC, Lyerly, HK, Bolognesi, DP, Weinhold, KJ
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired Immunodeficiency Syndrome - immunology AIDS/HIV Antibody-Dependent Cell Cytotoxicity Biological and medical sciences Dose-Response Relationship, Immunologic HIV Antibodies - immunology HIV Envelope Protein gp120 - immunology HIV Infections - immunology HIV Seropositivity - immunology HIV-1 - immunology Humans Immunity, Cellular Immunity, Innate Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Killer Cells, Natural - immunology Medical sciences
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