The complement-inhibitory activity of CD59 resides in its capacity to block incorporation of C9 into membrane C5b-9

A human E membrane protein that inhibits lysis by the purified human C5b-9 proteins was isolated and characterized. After final purification, the protein migrated as an 18- to 20-kDa band by SDS-PAGE. Elution from gel slices and functional assay after SDS-PAGE (nonreduced) confirmed that all C5b-9 i...

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Veröffentlicht in:	The Journal of immunology (1950) 1990-05, Vol.144 (9), p.3478-3483
Hauptverfasser:	Rollins, SA, Sims, PJ
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, Differentiation - physiology Biological and medical sciences CD59 Antigens Complement Complement C9 - metabolism Complement Membrane Attack Complex - metabolism Complement System Proteins - metabolism Erythrocyte Membrane - physiology Fundamental and applied biological sciences. Psychology Fundamental immunology Glycosylphosphatidylinositols Humans In Vitro Techniques Macromolecular Substances Membrane Proteins - physiology Molecular immunology Phosphatidylinositols - metabolism Polymers Polysaccharides - metabolism Protein Binding
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