Control of the activity of the soluble lytic transglycosylase by the stringent response in Escherichia coli

The soluble lytic transglycosylase (Slt) of Escherichia coli is known to be a powerful murein hydrolase in vitro. It is shown here to act as an autolysin in vivo as well. Rapid autolysis of Slt overproducing cells was induced by protein bio-synthesis inhibitors, which also block the fomration of gua...

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Veröffentlicht in:	FEMS microbiology letters 1990-01, Vol.67 (1-2), p.161-164
Hauptverfasser:	Betzner, A.S., Ferreira, L.C.S., Höltje, J.-V., Keck, W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - pharmacology Anti-Bacterial Agents - pharmacology Autolysis Escherichia coli - drug effects Escherichia coli - enzymology Glycosyltransferases Guanosine Tetraphosphate - pharmacology Murein N-Acetylmuramoyl-L-alanine Amidase - antagonists & inhibitors N-Acetylmuramoyl-L-alanine Amidase - metabolism Protein Synthesis Inhibitors - pharmacology RelA Salt Solubility Soluble lytic transglycosylase Transferases - antagonists & inhibitors Transferases - metabolism
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