Infrequent but efficient interferon-α-producing human mononuclear leukocytes induced by herpes simplex virus in vitro studied by immuno-plaque and limiting dilution assays

Human blood mononuclear leukocytes (PBMCs) producing interferon-alpha (IFN-alpha) after stimulation by herpes simplex virus type 1 (HSV) in vitro were identified by a filter immuno-plaque assay. Individual IFN-alpha-producing cells (IPCs) yielded between 0.5 and 2 units IFN-alpha, sufficient to prot...

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Veröffentlicht in:	Journal of interferon research 1990-02, Vol.10 (1), p.65-73
Hauptverfasser:	CEDERBLAD, B, ALM, G. V
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of the immune response. Humoral and cellular immunity Biological and medical sciences Cells, Cultured Fundamental and applied biological sciences. Psychology Fundamental immunology herpes simplex virus Humans Immunobiology Immunologic Techniques Interferon Type I - biosynthesis Kinetics Leukocyte Count Leukocytes, Mononuclear - immunology Lymphokines, interleukins ( function, expression) Regulatory factors and their cellular receptors Simplexvirus - immunology
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