Local Synthesis of C3 Within the Splenic Lymphoid Compartment Can Reconstitute the Impaired Immune Response in C3-Deficient Mice

Mice bearing a disrupted C3 locus (C3-/-) have an impaired Ab response to T-dependent Ags (bacteriophage phiX 174 and nuclear protein-keyhole limpet hemocyanin) characterized by a reduction in number and size of germinal centers and impaired retention of Ag by follicular dendritic cells. To test the...

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Veröffentlicht in:	The Journal of immunology (1950) 1998-03, Vol.160 (6), p.2619-2625
Hauptverfasser:	Fischer, Michael B, Ma, Minghe, Hsu, Nelson C, Carroll, Michael C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens - immunology Bone Marrow Transplantation Complement C3 - biosynthesis Complement C3 - deficiency Complement C3 - genetics Dendritic Cells - physiology Interferon-gamma - physiology Mice Spleen - immunology
Online-Zugang:	Volltext
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