Potential Role of Resident Islet Macrophage Activation in the Initiation of Autoimmune Diabetes

The purpose of this study was to evaluate the effects of resident islet macrophage activation on beta cell function. Treatment of freshly isolated rat islets with TNF-alpha and LPS results in a potent inhibition of glucose-stimulated insulin secretion. The inhibitory actions of TNF + LPS are mediate...

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Veröffentlicht in:	The Journal of immunology (1950) 1998-03, Vol.160 (6), p.2684-2691
Hauptverfasser:	Arnush, Marc, Scarim, Anna L, Heitmeier, Monique R, Kelly, Colleen B, Corbett, John A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Diabetes Mellitus, Type 1 - etiology Insulin - metabolism Insulin Secretion Interleukin-1 - analysis Interleukin-1 - metabolism Islets of Langerhans - physiology Lipopolysaccharides - pharmacology Macrophage Activation Male Nitric Oxide - physiology Nitric Oxide Synthase - genetics Nitric Oxide Synthase Type II Nitrites - metabolism Organ Culture Techniques Rats Rats, Sprague-Dawley RNA, Messenger - analysis Tumor Necrosis Factor-alpha - pharmacology
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