Influence of Aloe vera on the glycosaminoglycans in the matrix of healing dermal wounds in rats
The influence of Aloe vera (L.) Burman f. on the glycosaminoglycan (GAG) components of the matrix in a healing wound was studied. Wound healing is a dynamic and complex sequence of events of which the major one is the synthesis of extracellular matrix components. The early stage of wound healing is...
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| Veröffentlicht in: | Journal of ethnopharmacology 1998, Vol.59 (3), p.179-186 |
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| creator | Chithra, P Sajithlal, G.B Chandrakasan, Gowri |
| description | The influence of
Aloe vera (L.) Burman f. on the glycosaminoglycan (GAG) components of the matrix in a healing wound was studied. Wound healing is a dynamic and complex sequence of events of which the major one is the synthesis of extracellular matrix components. The early stage of wound healing is characterized by the laying down of a provisional matrix, which is then followed by the formation of granulation tissue and synthesis of collagen and elastin. The provisional matrix or the ground substance consists of GAGs and proteoglycans (PGs), which are protein–GAG conjugates. In the present work, we have studied the influence of
Aloe vera on the content of GAG and its types in the granulation tissue of healing wounds. We have also reported the levels of a few enzymes involved in matrix metabolism. The amount of ground substance synthesized was found to be higher in the treated wounds, and in particular, hyaluronic acid and dermatan sulphate levels were increased. The levels of the reported glycohydrolases were elevated on treatment with
Aloe vera, indicating increased turnover of the matrix. Both topical and oral treatments with
Aloe vera were found to have a positive influence on the synthesis of GAGs and thereby beneficially modulate wound healing. |
| doi_str_mv | 10.1016/S0378-8741(97)00112-8 |
| format | Article |
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Aloe vera (L.) Burman f. on the glycosaminoglycan (GAG) components of the matrix in a healing wound was studied. Wound healing is a dynamic and complex sequence of events of which the major one is the synthesis of extracellular matrix components. The early stage of wound healing is characterized by the laying down of a provisional matrix, which is then followed by the formation of granulation tissue and synthesis of collagen and elastin. The provisional matrix or the ground substance consists of GAGs and proteoglycans (PGs), which are protein–GAG conjugates. In the present work, we have studied the influence of
Aloe vera on the content of GAG and its types in the granulation tissue of healing wounds. We have also reported the levels of a few enzymes involved in matrix metabolism. The amount of ground substance synthesized was found to be higher in the treated wounds, and in particular, hyaluronic acid and dermatan sulphate levels were increased. The levels of the reported glycohydrolases were elevated on treatment with
Aloe vera, indicating increased turnover of the matrix. Both topical and oral treatments with
Aloe vera were found to have a positive influence on the synthesis of GAGs and thereby beneficially modulate wound healing.</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/S0378-8741(97)00112-8</identifier><identifier>PMID: 9507902</identifier><identifier>CODEN: JOETD7</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Acetylglucosaminidase - metabolism ; Aloe - chemistry ; Aloe vera ; Animals ; Biological and medical sciences ; Extracellular Matrix - drug effects ; Extracellular Matrix - metabolism ; General pharmacology ; Glucuronidase - metabolism ; Glycohydrolases ; Glycosaminoglycans ; Glycosaminoglycans - metabolism ; human health and safety ; Male ; Medical sciences ; medicine ; nonfood plant products ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Plant Extracts - pharmacology ; Plants, Medicinal ; Rats ; Rats, Wistar ; Skin - enzymology ; Skin - injuries ; Skin - pathology ; Wound healing ; Wound Healing - drug effects</subject><ispartof>Journal of ethnopharmacology, 1998, Vol.59 (3), p.179-186</ispartof><rights>1998 Elsevier Science Ireland Ltd</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c479t-7740710c4e8237c8af6ec7d0332c95b4563e496971995e79ff908c2a1b75a3803</citedby><cites>FETCH-LOGICAL-c479t-7740710c4e8237c8af6ec7d0332c95b4563e496971995e79ff908c2a1b75a3803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0378-8741(97)00112-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,4021,27921,27922,27923,45993</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2134692$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9507902$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chithra, P</creatorcontrib><creatorcontrib>Sajithlal, G.B</creatorcontrib><creatorcontrib>Chandrakasan, Gowri</creatorcontrib><title>Influence of Aloe vera on the glycosaminoglycans in the matrix of healing dermal wounds in rats</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>The influence of
Aloe vera (L.) Burman f. on the glycosaminoglycan (GAG) components of the matrix in a healing wound was studied. Wound healing is a dynamic and complex sequence of events of which the major one is the synthesis of extracellular matrix components. The early stage of wound healing is characterized by the laying down of a provisional matrix, which is then followed by the formation of granulation tissue and synthesis of collagen and elastin. The provisional matrix or the ground substance consists of GAGs and proteoglycans (PGs), which are protein–GAG conjugates. In the present work, we have studied the influence of
Aloe vera on the content of GAG and its types in the granulation tissue of healing wounds. We have also reported the levels of a few enzymes involved in matrix metabolism. The amount of ground substance synthesized was found to be higher in the treated wounds, and in particular, hyaluronic acid and dermatan sulphate levels were increased. The levels of the reported glycohydrolases were elevated on treatment with
Aloe vera, indicating increased turnover of the matrix. Both topical and oral treatments with
Aloe vera were found to have a positive influence on the synthesis of GAGs and thereby beneficially modulate wound healing.</description><subject>Acetylglucosaminidase - metabolism</subject><subject>Aloe - chemistry</subject><subject>Aloe vera</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Extracellular Matrix - drug effects</subject><subject>Extracellular Matrix - metabolism</subject><subject>General pharmacology</subject><subject>Glucuronidase - metabolism</subject><subject>Glycohydrolases</subject><subject>Glycosaminoglycans</subject><subject>Glycosaminoglycans - metabolism</subject><subject>human health and safety</subject><subject>Male</subject><subject>Medical sciences</subject><subject>medicine</subject><subject>nonfood plant products</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Plant Extracts - pharmacology</subject><subject>Plants, Medicinal</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Skin - enzymology</subject><subject>Skin - injuries</subject><subject>Skin - pathology</subject><subject>Wound healing</subject><subject>Wound Healing - drug effects</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi0EKsvCT6jwASE4BPyRZOxTVVV8VKrEofRseZ3x1siJi50U-u9JNqu9crKled7xzGNCzjn7xBlvP98yCapSUPMPGj4yxrmo1DOy4QpEBQ3I52RzQl6SV6X8YowBr9kZOdMNA83EhpjrwccJB4c0eXoZE9JHzJamgY73SPfxyaVi-zCk5WqHQsNa6e2Yw98ldI82hmFPO8y9jfRPmobugGU7ltfkhbex4JvjuSV3X7_8vPpe3fz4dn11eVO5GvRYAdTzaMzVqIQEp6xv0UHHpBRON7u6aSXWutXAtW4QtPeaKScs30FjpWJyS96vfR9y-j1hGU0fisMY7YBpKgY0CA1z8y1pVtDlVEpGbx5y6G1-MpyZRaw5iDWLNaPBHMQaNefOjw9Mux67U-pocq6_O9ZtcTb6bAcXygkTXNatXrC3K-ZtMnafZ-TuVjAumVDQtnzZ5GIlcNb1GDCb4sLyQV3I6EbTpfCfUf8Bkd-dAw</recordid><startdate>1998</startdate><enddate>1998</enddate><creator>Chithra, P</creator><creator>Sajithlal, G.B</creator><creator>Chandrakasan, Gowri</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1998</creationdate><title>Influence of Aloe vera on the glycosaminoglycans in the matrix of healing dermal wounds in rats</title><author>Chithra, P ; Sajithlal, G.B ; Chandrakasan, Gowri</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c479t-7740710c4e8237c8af6ec7d0332c95b4563e496971995e79ff908c2a1b75a3803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Acetylglucosaminidase - metabolism</topic><topic>Aloe - chemistry</topic><topic>Aloe vera</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Extracellular Matrix - drug effects</topic><topic>Extracellular Matrix - metabolism</topic><topic>General pharmacology</topic><topic>Glucuronidase - metabolism</topic><topic>Glycohydrolases</topic><topic>Glycosaminoglycans</topic><topic>Glycosaminoglycans - metabolism</topic><topic>human health and safety</topic><topic>Male</topic><topic>Medical sciences</topic><topic>medicine</topic><topic>nonfood plant products</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Plant Extracts - pharmacology</topic><topic>Plants, Medicinal</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Skin - enzymology</topic><topic>Skin - injuries</topic><topic>Skin - pathology</topic><topic>Wound healing</topic><topic>Wound Healing - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chithra, P</creatorcontrib><creatorcontrib>Sajithlal, G.B</creatorcontrib><creatorcontrib>Chandrakasan, Gowri</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chithra, P</au><au>Sajithlal, G.B</au><au>Chandrakasan, Gowri</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of Aloe vera on the glycosaminoglycans in the matrix of healing dermal wounds in rats</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>1998</date><risdate>1998</risdate><volume>59</volume><issue>3</issue><spage>179</spage><epage>186</epage><pages>179-186</pages><issn>0378-8741</issn><eissn>1872-7573</eissn><coden>JOETD7</coden><abstract>The influence of
Aloe vera (L.) Burman f. on the glycosaminoglycan (GAG) components of the matrix in a healing wound was studied. Wound healing is a dynamic and complex sequence of events of which the major one is the synthesis of extracellular matrix components. The early stage of wound healing is characterized by the laying down of a provisional matrix, which is then followed by the formation of granulation tissue and synthesis of collagen and elastin. The provisional matrix or the ground substance consists of GAGs and proteoglycans (PGs), which are protein–GAG conjugates. In the present work, we have studied the influence of
Aloe vera on the content of GAG and its types in the granulation tissue of healing wounds. We have also reported the levels of a few enzymes involved in matrix metabolism. The amount of ground substance synthesized was found to be higher in the treated wounds, and in particular, hyaluronic acid and dermatan sulphate levels were increased. The levels of the reported glycohydrolases were elevated on treatment with
Aloe vera, indicating increased turnover of the matrix. Both topical and oral treatments with
Aloe vera were found to have a positive influence on the synthesis of GAGs and thereby beneficially modulate wound healing.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>9507902</pmid><doi>10.1016/S0378-8741(97)00112-8</doi><tpages>8</tpages></addata></record> |
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| subjects | Acetylglucosaminidase - metabolism Aloe - chemistry Aloe vera Animals Biological and medical sciences Extracellular Matrix - drug effects Extracellular Matrix - metabolism General pharmacology Glucuronidase - metabolism Glycohydrolases Glycosaminoglycans Glycosaminoglycans - metabolism human health and safety Male Medical sciences medicine nonfood plant products Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Extracts - pharmacology Plants, Medicinal Rats Rats, Wistar Skin - enzymology Skin - injuries Skin - pathology Wound healing Wound Healing - drug effects |
| title | Influence of Aloe vera on the glycosaminoglycans in the matrix of healing dermal wounds in rats |
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