ADP‐ribosylation of proteins in brain regions of rats during postnatal development
Post‐translational modifications of chromatin‐bound proteins play an important role in the regulation of eukaryotic gene expression. Processes such as acetylation, methylation, phosphorylation and ADP‐ribosylation may alter the interaction of these proteins with DNA and consequently affect chromatin...
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| Veröffentlicht in: | International journal of developmental neuroscience 1990, Vol.8 (2), p.167-174 |
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| container_title | International journal of developmental neuroscience |
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| creator | Spina‐Purrello, V. Avola, R. Condorelli, D. F. Nicoletti, V. G. Insirello, L. Reale, S. Costa, A. Ragusa, N. Stella, A. M. Giuffrida |
| description | Post‐translational modifications of chromatin‐bound proteins play an important role in the regulation of eukaryotic gene expression. Processes such as acetylation, methylation, phosphorylation and ADP‐ribosylation may alter the interaction of these proteins with DNA and consequently affect chromatin conformation and the binding of enzymes and other molecules involved in the regulation of gene expression.
In the present study the process of ADP‐ribosylation of chromosomal proteins (histone and nonhistone proteins) in some rat brain regions during postnatal development was investigated; also the effect of epidermal growth factor (EGF) on this process in fetal brain slices was studied.
It has been found that the process of ADP‐ribosylation of total histones extracted from rat cerebral cortex and cerebellum at 1, 10 and 30 days of age, increases from 1 to 10 days of age (i.e. the period of maximal cell proliferation) and decreases thereafter, while the process of ADP‐ribosylation of nonhistone proteins (NHPs) sharply decreases during the same developmental period.
The addition of EGF to fetal brain slices causes a significant increase of ADP‐ribosylation of total histones (particularly of the histone H1 fraction) and also of NHPs and microsomal proteins. This result is in agreement with the effect of EGF as a mitogen factor, previously shown in astroglial cell cultures. |
| doi_str_mv | 10.1016/0736-5748(90)90007-O |
| format | Article |
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In the present study the process of ADP‐ribosylation of chromosomal proteins (histone and nonhistone proteins) in some rat brain regions during postnatal development was investigated; also the effect of epidermal growth factor (EGF) on this process in fetal brain slices was studied.
It has been found that the process of ADP‐ribosylation of total histones extracted from rat cerebral cortex and cerebellum at 1, 10 and 30 days of age, increases from 1 to 10 days of age (i.e. the period of maximal cell proliferation) and decreases thereafter, while the process of ADP‐ribosylation of nonhistone proteins (NHPs) sharply decreases during the same developmental period.
The addition of EGF to fetal brain slices causes a significant increase of ADP‐ribosylation of total histones (particularly of the histone H1 fraction) and also of NHPs and microsomal proteins. This result is in agreement with the effect of EGF as a mitogen factor, previously shown in astroglial cell cultures.</description><identifier>ISSN: 0736-5748</identifier><identifier>EISSN: 1873-474X</identifier><identifier>DOI: 10.1016/0736-5748(90)90007-O</identifier><identifier>PMID: 2327288</identifier><identifier>CODEN: IJDND6</identifier><language>eng</language><publisher>Oxford: Elsevier</publisher><subject>Adenosine Diphosphate Ribose - metabolism ; ADPRT ; ADP‐ribosyltransferase ; Aging - metabolism ; Animals ; Biochemistry and metabolism ; Biological and medical sciences ; Brain - drug effects ; Brain - growth & development ; Brain - metabolism ; Central nervous system ; Chromosomal Proteins, Non-Histone - metabolism ; EGF ; Embryo, Mammalian ; epidermal growth factor ; Epidermal Growth Factor - pharmacology ; Fundamental and applied biological sciences. Psychology ; Histones - metabolism ; In Vitro Techniques ; M.W ; molecular weight ; NHPs ; non‐histone proteins ; Protein Processing, Post-Translational ; Rats ; Rats, Inbred Strains ; Vertebrates: nervous system and sense organs</subject><ispartof>International journal of developmental neuroscience, 1990, Vol.8 (2), p.167-174</ispartof><rights>1990 ISDN</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c424O-bd5faac78fbfd141820d4c234942d1effb41c2bc218cb8b0f2e6b3f3b16f82a03</citedby><cites>FETCH-LOGICAL-c424O-bd5faac78fbfd141820d4c234942d1effb41c2bc218cb8b0f2e6b3f3b16f82a03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6875726$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2327288$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Spina‐Purrello, V.</creatorcontrib><creatorcontrib>Avola, R.</creatorcontrib><creatorcontrib>Condorelli, D. F.</creatorcontrib><creatorcontrib>Nicoletti, V. G.</creatorcontrib><creatorcontrib>Insirello, L.</creatorcontrib><creatorcontrib>Reale, S.</creatorcontrib><creatorcontrib>Costa, A.</creatorcontrib><creatorcontrib>Ragusa, N.</creatorcontrib><creatorcontrib>Stella, A. M. Giuffrida</creatorcontrib><title>ADP‐ribosylation of proteins in brain regions of rats during postnatal development</title><title>International journal of developmental neuroscience</title><addtitle>Int J Dev Neurosci</addtitle><description>Post‐translational modifications of chromatin‐bound proteins play an important role in the regulation of eukaryotic gene expression. Processes such as acetylation, methylation, phosphorylation and ADP‐ribosylation may alter the interaction of these proteins with DNA and consequently affect chromatin conformation and the binding of enzymes and other molecules involved in the regulation of gene expression.
In the present study the process of ADP‐ribosylation of chromosomal proteins (histone and nonhistone proteins) in some rat brain regions during postnatal development was investigated; also the effect of epidermal growth factor (EGF) on this process in fetal brain slices was studied.
It has been found that the process of ADP‐ribosylation of total histones extracted from rat cerebral cortex and cerebellum at 1, 10 and 30 days of age, increases from 1 to 10 days of age (i.e. the period of maximal cell proliferation) and decreases thereafter, while the process of ADP‐ribosylation of nonhistone proteins (NHPs) sharply decreases during the same developmental period.
The addition of EGF to fetal brain slices causes a significant increase of ADP‐ribosylation of total histones (particularly of the histone H1 fraction) and also of NHPs and microsomal proteins. This result is in agreement with the effect of EGF as a mitogen factor, previously shown in astroglial cell cultures.</description><subject>Adenosine Diphosphate Ribose - metabolism</subject><subject>ADPRT</subject><subject>ADP‐ribosyltransferase</subject><subject>Aging - metabolism</subject><subject>Animals</subject><subject>Biochemistry and metabolism</subject><subject>Biological and medical sciences</subject><subject>Brain - drug effects</subject><subject>Brain - growth & development</subject><subject>Brain - metabolism</subject><subject>Central nervous system</subject><subject>Chromosomal Proteins, Non-Histone - metabolism</subject><subject>EGF</subject><subject>Embryo, Mammalian</subject><subject>epidermal growth factor</subject><subject>Epidermal Growth Factor - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Histones - metabolism</subject><subject>In Vitro Techniques</subject><subject>M.W</subject><subject>molecular weight</subject><subject>NHPs</subject><subject>non‐histone proteins</subject><subject>Protein Processing, Post-Translational</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0736-5748</issn><issn>1873-474X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1OwzAUhC0EKqVwA5CyQAgWAf8ldpYV_6giLIrEzrIduzJKk2InoO44AmfkJCS06hY2tjTzvXlPA8AhgucIovQCMpLGCaP8NINnGYSQxfkWGCLOSEwZfdkGww2yC_ZCeO2YJIF0AAaYYIY5H4Lp-Orp-_PLO1WHZSkbV1dRbaOFrxvjqhC5KlJedq83s84LvellE6Ki9a6aRYs6NJVsZBkV5t2U9WJuqmYf7FhZBnOw_kfg-eZ6enkXT_Lb-8vxJNYU0zxWRWKl1IxbZQtEEcewoBoTmlFcIGOtokhjpTHiWnEFLTapIpYolFqOJSQjcLLK7c59a01oxNwFbcpSVqZug2AZwymh5E8QJQnPMtYn0hWofR2CN1YsvJtLvxQIir510Vcq-kpFBsVv6yLvxo7W-a2am2IztK6584_XvgxaltbLSruwwVLOkv7SEbheYR-uNMt_rRYPV4-93ssZ_BVz8gPXhp_O</recordid><startdate>1990</startdate><enddate>1990</enddate><creator>Spina‐Purrello, V.</creator><creator>Avola, R.</creator><creator>Condorelli, D. F.</creator><creator>Nicoletti, V. G.</creator><creator>Insirello, L.</creator><creator>Reale, S.</creator><creator>Costa, A.</creator><creator>Ragusa, N.</creator><creator>Stella, A. M. Giuffrida</creator><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>1990</creationdate><title>ADP‐ribosylation of proteins in brain regions of rats during postnatal development</title><author>Spina‐Purrello, V. ; Avola, R. ; Condorelli, D. F. ; Nicoletti, V. G. ; Insirello, L. ; Reale, S. ; Costa, A. ; Ragusa, N. ; Stella, A. M. Giuffrida</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c424O-bd5faac78fbfd141820d4c234942d1effb41c2bc218cb8b0f2e6b3f3b16f82a03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Adenosine Diphosphate Ribose - metabolism</topic><topic>ADPRT</topic><topic>ADP‐ribosyltransferase</topic><topic>Aging - metabolism</topic><topic>Animals</topic><topic>Biochemistry and metabolism</topic><topic>Biological and medical sciences</topic><topic>Brain - drug effects</topic><topic>Brain - growth & development</topic><topic>Brain - metabolism</topic><topic>Central nervous system</topic><topic>Chromosomal Proteins, Non-Histone - metabolism</topic><topic>EGF</topic><topic>Embryo, Mammalian</topic><topic>epidermal growth factor</topic><topic>Epidermal Growth Factor - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Histones - metabolism</topic><topic>In Vitro Techniques</topic><topic>M.W</topic><topic>molecular weight</topic><topic>NHPs</topic><topic>non‐histone proteins</topic><topic>Protein Processing, Post-Translational</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Spina‐Purrello, V.</creatorcontrib><creatorcontrib>Avola, R.</creatorcontrib><creatorcontrib>Condorelli, D. F.</creatorcontrib><creatorcontrib>Nicoletti, V. G.</creatorcontrib><creatorcontrib>Insirello, L.</creatorcontrib><creatorcontrib>Reale, S.</creatorcontrib><creatorcontrib>Costa, A.</creatorcontrib><creatorcontrib>Ragusa, N.</creatorcontrib><creatorcontrib>Stella, A. M. 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Giuffrida</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>ADP‐ribosylation of proteins in brain regions of rats during postnatal development</atitle><jtitle>International journal of developmental neuroscience</jtitle><addtitle>Int J Dev Neurosci</addtitle><date>1990</date><risdate>1990</risdate><volume>8</volume><issue>2</issue><spage>167</spage><epage>174</epage><pages>167-174</pages><issn>0736-5748</issn><eissn>1873-474X</eissn><coden>IJDND6</coden><abstract>Post‐translational modifications of chromatin‐bound proteins play an important role in the regulation of eukaryotic gene expression. Processes such as acetylation, methylation, phosphorylation and ADP‐ribosylation may alter the interaction of these proteins with DNA and consequently affect chromatin conformation and the binding of enzymes and other molecules involved in the regulation of gene expression.
In the present study the process of ADP‐ribosylation of chromosomal proteins (histone and nonhistone proteins) in some rat brain regions during postnatal development was investigated; also the effect of epidermal growth factor (EGF) on this process in fetal brain slices was studied.
It has been found that the process of ADP‐ribosylation of total histones extracted from rat cerebral cortex and cerebellum at 1, 10 and 30 days of age, increases from 1 to 10 days of age (i.e. the period of maximal cell proliferation) and decreases thereafter, while the process of ADP‐ribosylation of nonhistone proteins (NHPs) sharply decreases during the same developmental period.
The addition of EGF to fetal brain slices causes a significant increase of ADP‐ribosylation of total histones (particularly of the histone H1 fraction) and also of NHPs and microsomal proteins. This result is in agreement with the effect of EGF as a mitogen factor, previously shown in astroglial cell cultures.</abstract><cop>Oxford</cop><pub>Elsevier</pub><pmid>2327288</pmid><doi>10.1016/0736-5748(90)90007-O</doi><tpages>8</tpages></addata></record> |
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| ispartof | International journal of developmental neuroscience, 1990, Vol.8 (2), p.167-174 |
| issn | 0736-5748 1873-474X |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adenosine Diphosphate Ribose - metabolism ADPRT ADP‐ribosyltransferase Aging - metabolism Animals Biochemistry and metabolism Biological and medical sciences Brain - drug effects Brain - growth & development Brain - metabolism Central nervous system Chromosomal Proteins, Non-Histone - metabolism EGF Embryo, Mammalian epidermal growth factor Epidermal Growth Factor - pharmacology Fundamental and applied biological sciences. Psychology Histones - metabolism In Vitro Techniques M.W molecular weight NHPs non‐histone proteins Protein Processing, Post-Translational Rats Rats, Inbred Strains Vertebrates: nervous system and sense organs |
| title | ADP‐ribosylation of proteins in brain regions of rats during postnatal development |
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