A molecular switch changes the signalling pathway used by the FcγRI antibody receptor to mobilise calcium

Background: Leukocytes express Fcγ receptors, which are specific for the constant region of immunoglobulin G. Aggregation of these receptors activates a repertoire of responses that can lead to targeted cell killing by antibody directed cellular cytotoxicity. The nature of the myeloid response to Fc...

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Veröffentlicht in:	Current biology 1998-02, Vol.8 (4), p.210-222
Hauptverfasser:	Melendez, Alirio, Floto, R.Andres, Cameron, Angus J., Gillooly, David J., Harnett, Margaret M., Allen, Janet M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bucladesine - pharmacology Calcium - metabolism Cell Differentiation - drug effects Cell Line Diglycerides - biosynthesis Enzyme Activation Gene Expression Regulation - drug effects Interferon-gamma - pharmacology Phospholipase D - metabolism Phosphotransferases (Alcohol Group Acceptor) - metabolism Receptors, IgG - genetics Receptors, IgG - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Signal Transduction
Online-Zugang:	Volltext
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