Randomised placebo-controlled study of atovaquone plus proguanil for malaria prophylaxis in children

The combination of atovaquone and proguanil is highly effective and safe for the treatment of Plasmodium falciparum malaria. We aimed in this randomised, double-blind, placebo-controlled study to assess the efficacy and safety of this combination for malaria prophylaxis. 320 children who lived in a...

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Veröffentlicht in:	The Lancet (British edition) 1998-03, Vol.351 (9104), p.709-713
Hauptverfasser:	Lell, Bertrand, Luckner, Doris, Ndjavé, Maryse, Scott, Trevor, Kremsner, Peter G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Antimalarials - administration & dosage Antimalarials - therapeutic use Atovaquone Biological and medical sciences Blood Child Child, Preschool Children & youth Cohort Studies Double-Blind Method Drug therapy Drug Therapy, Combination Human protozoal diseases Humans Infectious diseases Malaria Malaria - prevention & control Medical research Medical sciences Naphthoquinones - administration & dosage Naphthoquinones - therapeutic use Parasitic diseases Population Proguanil - administration & dosage Proguanil - therapeutic use Prophylaxis Protozoal diseases Tropical medicine Vector-borne diseases
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