Dopamine markers and general cognitive ability
BECAUSE general cognitive ability (g) is among the most heritable behavioural traits, it is a reasonable target for a search for quantitative trait loci (QTLs). We used a selected-extremes design to test candidate genes for allelic association with g. Polymorphisms in four genes in the dopamine syst...
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| Veröffentlicht in: | Neuroreport 1998-01, Vol.9 (2), p.347-349 |
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| container_title | Neuroreport |
| container_volume | 9 |
| creator | Ball, David Hill, Linzy Eley, Thalia C Chorney, Michael J Chorney, Karen Thompson, Lee A Detterman, Douglas K Benbow, Camilla Lubinski, David Owen, Michael McGuffin, Peter Plomin, Robert |
| description | BECAUSE general cognitive ability (g) is among the most heritable behavioural traits, it is a reasonable target for a search for quantitative trait loci (QTLs). We used a selected-extremes design to test candidate genes for allelic association with g. Polymorphisms in four genes in the dopamine system (DRD2, DRD3, DRD4, DAT1) were genotyped for 51 high g children with IQ scores > 130 and for 51 average g control children. No significant allelic or genotypic differences were found between the high g and average g groups for these markers of the dopamine system, even though the selected-extremes design provides power to detect QTL associations that involve a relative risk of about 1.5. |
| doi_str_mv | 10.1097/00001756-199801260-00031 |
| format | Article |
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We used a selected-extremes design to test candidate genes for allelic association with g. Polymorphisms in four genes in the dopamine system (DRD2, DRD3, DRD4, DAT1) were genotyped for 51 high g children with IQ scores > 130 and for 51 average g control children. No significant allelic or genotypic differences were found between the high g and average g groups for these markers of the dopamine system, even though the selected-extremes design provides power to detect QTL associations that involve a relative risk of about 1.5.</description><identifier>ISSN: 0959-4965</identifier><identifier>EISSN: 1473-558X</identifier><identifier>DOI: 10.1097/00001756-199801260-00031</identifier><identifier>PMID: 9507981</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott-Raven Publishers</publisher><subject>Adolescent ; Alleles ; Biological and medical sciences ; Biomarkers ; Child ; Classical genetics, quantitative genetics, hybrids ; Cognition - physiology ; DNA - analysis ; Dopamine - genetics ; Dopamine - physiology ; Female ; Fundamental and applied biological sciences. Psychology ; Genetics of eukaryotes. Biological and molecular evolution ; Genotype ; Human ; Humans ; Intelligence Tests ; Male ; Polymorphism, Genetic ; Quantitative Trait, Heritable</subject><ispartof>Neuroreport, 1998-01, Vol.9 (2), p.347-349</ispartof><rights>Lippincott-Raven Publishers.</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4151-6c3afa95e4210235e27e35421fae96e3e8dabb1519d7938511cb71fded0e39c53</citedby><cites>FETCH-LOGICAL-c4151-6c3afa95e4210235e27e35421fae96e3e8dabb1519d7938511cb71fded0e39c53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2129512$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9507981$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ball, David</creatorcontrib><creatorcontrib>Hill, Linzy</creatorcontrib><creatorcontrib>Eley, Thalia C</creatorcontrib><creatorcontrib>Chorney, Michael J</creatorcontrib><creatorcontrib>Chorney, Karen</creatorcontrib><creatorcontrib>Thompson, Lee A</creatorcontrib><creatorcontrib>Detterman, Douglas K</creatorcontrib><creatorcontrib>Benbow, Camilla</creatorcontrib><creatorcontrib>Lubinski, David</creatorcontrib><creatorcontrib>Owen, Michael</creatorcontrib><creatorcontrib>McGuffin, Peter</creatorcontrib><creatorcontrib>Plomin, Robert</creatorcontrib><title>Dopamine markers and general cognitive ability</title><title>Neuroreport</title><addtitle>Neuroreport</addtitle><description>BECAUSE general cognitive ability (g) is among the most heritable behavioural traits, it is a reasonable target for a search for quantitative trait loci (QTLs). 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No significant allelic or genotypic differences were found between the high g and average g groups for these markers of the dopamine system, even though the selected-extremes design provides power to detect QTL associations that involve a relative risk of about 1.5.</description><subject>Adolescent</subject><subject>Alleles</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Child</subject><subject>Classical genetics, quantitative genetics, hybrids</subject><subject>Cognition - physiology</subject><subject>DNA - analysis</subject><subject>Dopamine - genetics</subject><subject>Dopamine - physiology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Genotype</subject><subject>Human</subject><subject>Humans</subject><subject>Intelligence Tests</subject><subject>Male</subject><subject>Polymorphism, Genetic</subject><subject>Quantitative Trait, Heritable</subject><issn>0959-4965</issn><issn>1473-558X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtLxDAQgIMouj5-gtCDeKtmkqbpHMU3CF4UvIU0nWo1265JV9l_b3TXvYlzCZP5ZoZ8YSwDfgIc9SlPAVqVOSBWHETJ83QjYYNNoNAyV6p62mQTjgrzAku1w3ZjfE0Icqi22TYqrrGCCTu5GGZ22vWUTW14oxAz2zfZM_UUrM_c8Nx3Y_dBma07342LfbbVWh_pYHXuscery4fzm_zu_vr2_OwudwUoyEsnbWtRUSGAC6lIaJIqJa0lLElS1di6TiQ2GmWlAFytoW2o4STRKbnHjpdzZ2F4n1MczbSLjry3PQ3zaDRqUQIv_gWhFFpILBNYLUEXhhgDtWYWuvTmhQFuvp2aX6dm7dT8OE2th6sd83pKzbpxJTHVj1Z1G531bbC96-IaEyBQgUhYscQ-Bz8m029-_knBvJD144v560flFzMZjJY</recordid><startdate>19980126</startdate><enddate>19980126</enddate><creator>Ball, David</creator><creator>Hill, Linzy</creator><creator>Eley, Thalia C</creator><creator>Chorney, Michael J</creator><creator>Chorney, Karen</creator><creator>Thompson, Lee A</creator><creator>Detterman, Douglas K</creator><creator>Benbow, Camilla</creator><creator>Lubinski, David</creator><creator>Owen, Michael</creator><creator>McGuffin, Peter</creator><creator>Plomin, Robert</creator><general>Lippincott-Raven Publishers</general><general>Lippincott Williams and Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19980126</creationdate><title>Dopamine markers and general cognitive ability</title><author>Ball, David ; Hill, Linzy ; Eley, Thalia C ; Chorney, Michael J ; Chorney, Karen ; Thompson, Lee A ; Detterman, Douglas K ; Benbow, Camilla ; Lubinski, David ; Owen, Michael ; McGuffin, Peter ; Plomin, Robert</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4151-6c3afa95e4210235e27e35421fae96e3e8dabb1519d7938511cb71fded0e39c53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adolescent</topic><topic>Alleles</topic><topic>Biological and medical sciences</topic><topic>Biomarkers</topic><topic>Child</topic><topic>Classical genetics, quantitative genetics, hybrids</topic><topic>Cognition - physiology</topic><topic>DNA - analysis</topic><topic>Dopamine - genetics</topic><topic>Dopamine - physiology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. 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We used a selected-extremes design to test candidate genes for allelic association with g. Polymorphisms in four genes in the dopamine system (DRD2, DRD3, DRD4, DAT1) were genotyped for 51 high g children with IQ scores > 130 and for 51 average g control children. No significant allelic or genotypic differences were found between the high g and average g groups for these markers of the dopamine system, even though the selected-extremes design provides power to detect QTL associations that involve a relative risk of about 1.5.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott-Raven Publishers</pub><pmid>9507981</pmid><doi>10.1097/00001756-199801260-00031</doi><tpages>3</tpages></addata></record> |
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| subjects | Adolescent Alleles Biological and medical sciences Biomarkers Child Classical genetics, quantitative genetics, hybrids Cognition - physiology DNA - analysis Dopamine - genetics Dopamine - physiology Female Fundamental and applied biological sciences. Psychology Genetics of eukaryotes. Biological and molecular evolution Genotype Human Humans Intelligence Tests Male Polymorphism, Genetic Quantitative Trait, Heritable |
| title | Dopamine markers and general cognitive ability |
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