Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines

The t(14;18) of human follicular B cell lymphoma translocates the Bcl-2 gene into the Ig H chain locus and markedly deregulates Bcl-2 expression. We sought to determine if Bcl-2 could be directly implicated in a growth-factor pathway. Consequently, we introduced a retrovirus containing the murine Bc...

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Veröffentlicht in:	The Journal of immunology (1950) 1990-05, Vol.144 (9), p.3602-3610
Hauptverfasser:	Nunez, G, London, L, Hockenbery, D, Alexander, M, McKearn, JP, Korsmeyer, SJ
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blotting, Northern Blotting, Southern Cell Line Cell Survival Cloning, Molecular Flow Cytometry Fundamental and applied biological sciences. Psychology Gene Expression Genetic Vectors Growth Substances - pharmacology Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - physiology Interleukin-2 - physiology Interleukin-3 - physiology Interleukin-6 - physiology Mice Molecular and cellular biology Molecular genetics Monosaccharide Transport Proteins - genetics Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - physiology Proto-Oncogene Proteins c-bcl-2 Proto-Oncogene Proteins c-myc RNA, Messenger - genetics
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