Assessment using ELISA of the herd immunity levels induced in cattle by foot-and-mouth disease oil vaccines
The development of a liquid-phase blocking sandwich ELISA (LPBE) to measure antibodies (Ab) produced in cattle with the O, A and C foot-and-mouth disease virus (FMDV) types of commercial vaccines used in Argentina is described. The test was specific: 99% of naïve cattle sera ( n = 130) gave titres b...
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| Veröffentlicht in: | Preventive veterinary medicine 1998, Vol.33 (1), p.283-296 |
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| creator | Smitsaart, E.N Zanelli, M Rivera, I Fondevila, N Compaired, D Maradei, E Bianchi, T O'Donnell, V Schudel, A.A |
| description | The development of a liquid-phase blocking sandwich ELISA (LPBE) to measure antibodies (Ab) produced in cattle with the O, A and C foot-and-mouth disease virus (FMDV) types of commercial vaccines used in Argentina is described. The test was specific: 99% of naïve cattle sera (
n = 130) gave titres below log
10 = 1.2, and none had a titre above log
10 = 1.5. Comparative studies with serum neutralization test (SNT) using sera from cattle which received one or more vaccine doses is reported. The overall rank correlation coefficient (Spearman's ϱ,
r
s) between SNT and LPBE were highly significant (
r
s > 0.67,
P < 0.0001) for all vaccine strains. LBPE Ab titres on sera collected 90 days post vaccination were compared with results of cattle protection tests by applying a logistic regression. The minimum Ab titres at which 85% and 75% of the cattle were protected for each FMDV type were determined in order to interpret field Ab data in terms of protection. Application of this method allows large scale serological examinations to monitor antibody levels in vaccinated animals as an indirect indicator of the FMD control program status in the field. Its use in the evaluation of commercial batches of FMD vaccine is discussed. |
| doi_str_mv | 10.1016/S0167-5877(97)00014-7 |
| format | Article |
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n = 130) gave titres below log
10 = 1.2, and none had a titre above log
10 = 1.5. Comparative studies with serum neutralization test (SNT) using sera from cattle which received one or more vaccine doses is reported. The overall rank correlation coefficient (Spearman's ϱ,
r
s) between SNT and LPBE were highly significant (
r
s > 0.67,
P < 0.0001) for all vaccine strains. LBPE Ab titres on sera collected 90 days post vaccination were compared with results of cattle protection tests by applying a logistic regression. The minimum Ab titres at which 85% and 75% of the cattle were protected for each FMDV type were determined in order to interpret field Ab data in terms of protection. Application of this method allows large scale serological examinations to monitor antibody levels in vaccinated animals as an indirect indicator of the FMD control program status in the field. Its use in the evaluation of commercial batches of FMD vaccine is discussed.</description><identifier>ISSN: 0167-5877</identifier><identifier>EISSN: 1873-1716</identifier><identifier>DOI: 10.1016/S0167-5877(97)00014-7</identifier><identifier>PMID: 9500182</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>ACEITES ; Animals ; Antibodies, Viral - blood ; APHTHOVIRUS ; Aphthovirus - immunology ; Argentina - epidemiology ; BOVIN ; CATTLE ; Cattle Diseases - epidemiology ; Cattle Diseases - immunology ; Cattle Diseases - prevention & control ; Disease Outbreaks - veterinary ; ELISA ; Enzyme-Linked Immunosorbent Assay - veterinary ; FIEBRE AFTOSA ; FIEVRE APHTEUSE ; FOOT AND MOUTH DISEASE ; Foot-and-Mouth Disease - epidemiology ; Foot-and-Mouth Disease - immunology ; Foot-and-Mouth Disease - prevention & control ; Foot-and-mouth disease vaccine ; GANADO BOVINO ; Herd immunity ; HUILE ; IMMUNITE ; IMMUNITY ; INMUNIDAD ; Liquid phase blocking sandwich ELISA ; Logistic Models ; Neutralization Tests - veterinary ; OILS ; Rabbits ; Relationship antibodies vs protection ; Reproducibility of Results ; Sensitivity and Specificity ; TEST ELISA ; VACCIN ; Vaccination - veterinary ; VACCINES ; VACUNA ; Viral Vaccines - immunology ; VIRUS FIEBRE AFTOSA ; VIRUS FIEVRE APHTEUSE</subject><ispartof>Preventive veterinary medicine, 1998, Vol.33 (1), p.283-296</ispartof><rights>1998</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c382t-ab63f15169bfe63606f904b2b097f0d6337a55ca2bed291aadeb6d8db15c13b83</citedby><cites>FETCH-LOGICAL-c382t-ab63f15169bfe63606f904b2b097f0d6337a55ca2bed291aadeb6d8db15c13b83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0167-5877(97)00014-7$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9500182$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Smitsaart, E.N</creatorcontrib><creatorcontrib>Zanelli, M</creatorcontrib><creatorcontrib>Rivera, I</creatorcontrib><creatorcontrib>Fondevila, N</creatorcontrib><creatorcontrib>Compaired, D</creatorcontrib><creatorcontrib>Maradei, E</creatorcontrib><creatorcontrib>Bianchi, T</creatorcontrib><creatorcontrib>O'Donnell, V</creatorcontrib><creatorcontrib>Schudel, A.A</creatorcontrib><title>Assessment using ELISA of the herd immunity levels induced in cattle by foot-and-mouth disease oil vaccines</title><title>Preventive veterinary medicine</title><addtitle>Prev Vet Med</addtitle><description>The development of a liquid-phase blocking sandwich ELISA (LPBE) to measure antibodies (Ab) produced in cattle with the O, A and C foot-and-mouth disease virus (FMDV) types of commercial vaccines used in Argentina is described. The test was specific: 99% of naïve cattle sera (
n = 130) gave titres below log
10 = 1.2, and none had a titre above log
10 = 1.5. Comparative studies with serum neutralization test (SNT) using sera from cattle which received one or more vaccine doses is reported. The overall rank correlation coefficient (Spearman's ϱ,
r
s) between SNT and LPBE were highly significant (
r
s > 0.67,
P < 0.0001) for all vaccine strains. LBPE Ab titres on sera collected 90 days post vaccination were compared with results of cattle protection tests by applying a logistic regression. The minimum Ab titres at which 85% and 75% of the cattle were protected for each FMDV type were determined in order to interpret field Ab data in terms of protection. Application of this method allows large scale serological examinations to monitor antibody levels in vaccinated animals as an indirect indicator of the FMD control program status in the field. Its use in the evaluation of commercial batches of FMD vaccine is discussed.</description><subject>ACEITES</subject><subject>Animals</subject><subject>Antibodies, Viral - blood</subject><subject>APHTHOVIRUS</subject><subject>Aphthovirus - immunology</subject><subject>Argentina - epidemiology</subject><subject>BOVIN</subject><subject>CATTLE</subject><subject>Cattle Diseases - epidemiology</subject><subject>Cattle Diseases - immunology</subject><subject>Cattle Diseases - prevention & control</subject><subject>Disease Outbreaks - veterinary</subject><subject>ELISA</subject><subject>Enzyme-Linked Immunosorbent Assay - veterinary</subject><subject>FIEBRE AFTOSA</subject><subject>FIEVRE APHTEUSE</subject><subject>FOOT AND MOUTH DISEASE</subject><subject>Foot-and-Mouth Disease - epidemiology</subject><subject>Foot-and-Mouth Disease - immunology</subject><subject>Foot-and-Mouth Disease - prevention & control</subject><subject>Foot-and-mouth disease vaccine</subject><subject>GANADO BOVINO</subject><subject>Herd immunity</subject><subject>HUILE</subject><subject>IMMUNITE</subject><subject>IMMUNITY</subject><subject>INMUNIDAD</subject><subject>Liquid phase blocking sandwich ELISA</subject><subject>Logistic Models</subject><subject>Neutralization Tests - veterinary</subject><subject>OILS</subject><subject>Rabbits</subject><subject>Relationship antibodies vs protection</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>TEST ELISA</subject><subject>VACCIN</subject><subject>Vaccination - veterinary</subject><subject>VACCINES</subject><subject>VACUNA</subject><subject>Viral Vaccines - immunology</subject><subject>VIRUS FIEBRE AFTOSA</subject><subject>VIRUS FIEVRE APHTEUSE</subject><issn>0167-5877</issn><issn>1873-1716</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v1DAQhi0EKkvhJ1TyCcEhYMcbOz6hVVVopRUcCmfLH-OuIYlLxllp_z1ud9UeuYyleZ-ZsR5CLjj7xBmXn29rUU3XK_VBq4-MMb5u1Auy4r0SDVdcviSrJ-Q1eYP4u0JS9t0ZOdNd5ft2Rf5sEAFxhKnQBdN0R6-2N7cbmiMtO6A7mANN47hMqRzoAHsYkKYpLB5qf6LeljIAdQcacy6NnUIz5qXsaEgIFoHmNNC99T5NgG_Jq2gHhHen95z8-nr18_K62f74dnO52TZe9G1d4qSIvONSuwhSSCajZmvXOqZVZEEKoWzXeds6CK3m1gZwMvTB8c5z4XpxTt4f997P-e8CWMyY0MMw2AnygkZp1a6ZFhXsjqCfM-IM0dzPabTzwXBmHiSbR8nmwaDRyjxKNqrOXZwOLG6E8DR1svqcR5uNvZsTmu9brnVfY9XKmn855tUm7BPMBn2CqTpNM_hiQk7_-cE_N2eVrQ</recordid><startdate>1998</startdate><enddate>1998</enddate><creator>Smitsaart, E.N</creator><creator>Zanelli, M</creator><creator>Rivera, I</creator><creator>Fondevila, N</creator><creator>Compaired, D</creator><creator>Maradei, E</creator><creator>Bianchi, T</creator><creator>O'Donnell, V</creator><creator>Schudel, A.A</creator><general>Elsevier B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1998</creationdate><title>Assessment using ELISA of the herd immunity levels induced in cattle by foot-and-mouth disease oil vaccines</title><author>Smitsaart, E.N ; Zanelli, M ; Rivera, I ; Fondevila, N ; Compaired, D ; Maradei, E ; Bianchi, T ; O'Donnell, V ; Schudel, A.A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c382t-ab63f15169bfe63606f904b2b097f0d6337a55ca2bed291aadeb6d8db15c13b83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>ACEITES</topic><topic>Animals</topic><topic>Antibodies, Viral - blood</topic><topic>APHTHOVIRUS</topic><topic>Aphthovirus - immunology</topic><topic>Argentina - epidemiology</topic><topic>BOVIN</topic><topic>CATTLE</topic><topic>Cattle Diseases - epidemiology</topic><topic>Cattle Diseases - immunology</topic><topic>Cattle Diseases - prevention & control</topic><topic>Disease Outbreaks - veterinary</topic><topic>ELISA</topic><topic>Enzyme-Linked Immunosorbent Assay - veterinary</topic><topic>FIEBRE AFTOSA</topic><topic>FIEVRE APHTEUSE</topic><topic>FOOT AND MOUTH DISEASE</topic><topic>Foot-and-Mouth Disease - epidemiology</topic><topic>Foot-and-Mouth Disease - immunology</topic><topic>Foot-and-Mouth Disease - prevention & control</topic><topic>Foot-and-mouth disease vaccine</topic><topic>GANADO BOVINO</topic><topic>Herd immunity</topic><topic>HUILE</topic><topic>IMMUNITE</topic><topic>IMMUNITY</topic><topic>INMUNIDAD</topic><topic>Liquid phase blocking sandwich ELISA</topic><topic>Logistic Models</topic><topic>Neutralization Tests - veterinary</topic><topic>OILS</topic><topic>Rabbits</topic><topic>Relationship antibodies vs protection</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><topic>TEST ELISA</topic><topic>VACCIN</topic><topic>Vaccination - veterinary</topic><topic>VACCINES</topic><topic>VACUNA</topic><topic>Viral Vaccines - immunology</topic><topic>VIRUS FIEBRE AFTOSA</topic><topic>VIRUS FIEVRE APHTEUSE</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Smitsaart, E.N</creatorcontrib><creatorcontrib>Zanelli, M</creatorcontrib><creatorcontrib>Rivera, I</creatorcontrib><creatorcontrib>Fondevila, N</creatorcontrib><creatorcontrib>Compaired, D</creatorcontrib><creatorcontrib>Maradei, E</creatorcontrib><creatorcontrib>Bianchi, T</creatorcontrib><creatorcontrib>O'Donnell, V</creatorcontrib><creatorcontrib>Schudel, A.A</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Preventive veterinary medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Smitsaart, E.N</au><au>Zanelli, M</au><au>Rivera, I</au><au>Fondevila, N</au><au>Compaired, D</au><au>Maradei, E</au><au>Bianchi, T</au><au>O'Donnell, V</au><au>Schudel, A.A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessment using ELISA of the herd immunity levels induced in cattle by foot-and-mouth disease oil vaccines</atitle><jtitle>Preventive veterinary medicine</jtitle><addtitle>Prev Vet Med</addtitle><date>1998</date><risdate>1998</risdate><volume>33</volume><issue>1</issue><spage>283</spage><epage>296</epage><pages>283-296</pages><issn>0167-5877</issn><eissn>1873-1716</eissn><abstract>The development of a liquid-phase blocking sandwich ELISA (LPBE) to measure antibodies (Ab) produced in cattle with the O, A and C foot-and-mouth disease virus (FMDV) types of commercial vaccines used in Argentina is described. The test was specific: 99% of naïve cattle sera (
n = 130) gave titres below log
10 = 1.2, and none had a titre above log
10 = 1.5. Comparative studies with serum neutralization test (SNT) using sera from cattle which received one or more vaccine doses is reported. The overall rank correlation coefficient (Spearman's ϱ,
r
s) between SNT and LPBE were highly significant (
r
s > 0.67,
P < 0.0001) for all vaccine strains. LBPE Ab titres on sera collected 90 days post vaccination were compared with results of cattle protection tests by applying a logistic regression. The minimum Ab titres at which 85% and 75% of the cattle were protected for each FMDV type were determined in order to interpret field Ab data in terms of protection. Application of this method allows large scale serological examinations to monitor antibody levels in vaccinated animals as an indirect indicator of the FMD control program status in the field. Its use in the evaluation of commercial batches of FMD vaccine is discussed.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>9500182</pmid><doi>10.1016/S0167-5877(97)00014-7</doi><tpages>14</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0167-5877 |
| ispartof | Preventive veterinary medicine, 1998, Vol.33 (1), p.283-296 |
| issn | 0167-5877 1873-1716 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79724093 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | ACEITES Animals Antibodies, Viral - blood APHTHOVIRUS Aphthovirus - immunology Argentina - epidemiology BOVIN CATTLE Cattle Diseases - epidemiology Cattle Diseases - immunology Cattle Diseases - prevention & control Disease Outbreaks - veterinary ELISA Enzyme-Linked Immunosorbent Assay - veterinary FIEBRE AFTOSA FIEVRE APHTEUSE FOOT AND MOUTH DISEASE Foot-and-Mouth Disease - epidemiology Foot-and-Mouth Disease - immunology Foot-and-Mouth Disease - prevention & control Foot-and-mouth disease vaccine GANADO BOVINO Herd immunity HUILE IMMUNITE IMMUNITY INMUNIDAD Liquid phase blocking sandwich ELISA Logistic Models Neutralization Tests - veterinary OILS Rabbits Relationship antibodies vs protection Reproducibility of Results Sensitivity and Specificity TEST ELISA VACCIN Vaccination - veterinary VACCINES VACUNA Viral Vaccines - immunology VIRUS FIEBRE AFTOSA VIRUS FIEVRE APHTEUSE |
| title | Assessment using ELISA of the herd immunity levels induced in cattle by foot-and-mouth disease oil vaccines |
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