0.125% Ropivacaine is similar to 0.125% bupivacaine for labor analgesia using patient-controlled epidural infusion
We compared the effects of 0.125% ropivacaine with 0.125% bupivacaine in laboring patients using patient-controlled epidural analgesia (PCEA). Fifty-one ASA physical status I or II term parturients with functioning epidural catheters were randomized to receive ropivacaine or bupivacaine using a pros...
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| Veröffentlicht in: | Anesthesia and analgesia 1998-03, Vol.86 (3), p.527-531 |
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| container_title | Anesthesia and analgesia |
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| creator | OWEN, M. D D'ANGELO, R GERANCHER, J. C THOMPSON, J. M FOSS, M. L BABB, J. D EISENACH, J. C |
| description | We compared the effects of 0.125% ropivacaine with 0.125% bupivacaine in laboring patients using patient-controlled epidural analgesia (PCEA). Fifty-one ASA physical status I or II term parturients with functioning epidural catheters were randomized to receive ropivacaine or bupivacaine using a prospective, double-blind design. Basal infusions (6 mL/h) were supplemented with patient-controlled boluses (5 mL) every 10 min as required. For inadequate analgesia, patients were administered 10-mL boluses of study solution until comfortable. There were no differences in verbal pain scores, amount of local anesthetics used, sensory levels, motor blockade, labor duration, mode of delivery, side effects, or patient satisfaction between the two local anesthetics. We conclude that 0.125% ropivacaine and bupivacaine are clinically indistinguishable and are both highly effective for labor analgesia using PCEA.
This study compared labor analgesia from 0.125% ropivacaine and 0.125% bupivacaine using patient-controlled epidural analgesia. We found no significant differences in local anesthetic use, analgesic characteristics, or side effects between 0.125% ropivacaine and 0.125% bupivacaine. We conclude that these two drugs are clinically indistinguishable at this concentration. |
| doi_str_mv | 10.1097/00000539-199803000-00015 |
| format | Article |
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This study compared labor analgesia from 0.125% ropivacaine and 0.125% bupivacaine using patient-controlled epidural analgesia. We found no significant differences in local anesthetic use, analgesic characteristics, or side effects between 0.125% ropivacaine and 0.125% bupivacaine. We conclude that these two drugs are clinically indistinguishable at this concentration.</description><identifier>ISSN: 0003-2999</identifier><identifier>EISSN: 1526-7598</identifier><identifier>DOI: 10.1097/00000539-199803000-00015</identifier><identifier>PMID: 9495407</identifier><identifier>CODEN: AACRAT</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott</publisher><subject>Adult ; Amides - administration & dosage ; Analgesia, Patient-Controlled - methods ; Anesthesia, Epidural - methods ; Anesthetics, Local - administration & dosage ; Anesthetics. Neuromuscular blocking agents ; Biological and medical sciences ; Blood Pressure - drug effects ; Bupivacaine - administration & dosage ; Female ; Humans ; Labor, Obstetric ; Medical sciences ; Neuropharmacology ; Parity ; Pharmacology. Drug treatments ; Pregnancy ; Prospective Studies ; Ropivacaine ; Self Administration</subject><ispartof>Anesthesia and analgesia, 1998-03, Vol.86 (3), p.527-531</ispartof><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-a70b376142bcbc180674ce8141ca4a2d70120b66b515c365d03b1c4c4fed4ce03</citedby><cites>FETCH-LOGICAL-c389t-a70b376142bcbc180674ce8141ca4a2d70120b66b515c365d03b1c4c4fed4ce03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2168837$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9495407$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>OWEN, M. D</creatorcontrib><creatorcontrib>D'ANGELO, R</creatorcontrib><creatorcontrib>GERANCHER, J. C</creatorcontrib><creatorcontrib>THOMPSON, J. M</creatorcontrib><creatorcontrib>FOSS, M. L</creatorcontrib><creatorcontrib>BABB, J. D</creatorcontrib><creatorcontrib>EISENACH, J. C</creatorcontrib><title>0.125% Ropivacaine is similar to 0.125% bupivacaine for labor analgesia using patient-controlled epidural infusion</title><title>Anesthesia and analgesia</title><addtitle>Anesth Analg</addtitle><description>We compared the effects of 0.125% ropivacaine with 0.125% bupivacaine in laboring patients using patient-controlled epidural analgesia (PCEA). Fifty-one ASA physical status I or II term parturients with functioning epidural catheters were randomized to receive ropivacaine or bupivacaine using a prospective, double-blind design. Basal infusions (6 mL/h) were supplemented with patient-controlled boluses (5 mL) every 10 min as required. For inadequate analgesia, patients were administered 10-mL boluses of study solution until comfortable. There were no differences in verbal pain scores, amount of local anesthetics used, sensory levels, motor blockade, labor duration, mode of delivery, side effects, or patient satisfaction between the two local anesthetics. We conclude that 0.125% ropivacaine and bupivacaine are clinically indistinguishable and are both highly effective for labor analgesia using PCEA.
This study compared labor analgesia from 0.125% ropivacaine and 0.125% bupivacaine using patient-controlled epidural analgesia. We found no significant differences in local anesthetic use, analgesic characteristics, or side effects between 0.125% ropivacaine and 0.125% bupivacaine. We conclude that these two drugs are clinically indistinguishable at this concentration.</description><subject>Adult</subject><subject>Amides - administration & dosage</subject><subject>Analgesia, Patient-Controlled - methods</subject><subject>Anesthesia, Epidural - methods</subject><subject>Anesthetics, Local - administration & dosage</subject><subject>Anesthetics. Neuromuscular blocking agents</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Bupivacaine - administration & dosage</subject><subject>Female</subject><subject>Humans</subject><subject>Labor, Obstetric</subject><subject>Medical sciences</subject><subject>Neuropharmacology</subject><subject>Parity</subject><subject>Pharmacology. 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C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-a70b376142bcbc180674ce8141ca4a2d70120b66b515c365d03b1c4c4fed4ce03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adult</topic><topic>Amides - administration & dosage</topic><topic>Analgesia, Patient-Controlled - methods</topic><topic>Anesthesia, Epidural - methods</topic><topic>Anesthetics, Local - administration & dosage</topic><topic>Anesthetics. Neuromuscular blocking agents</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - drug effects</topic><topic>Bupivacaine - administration & dosage</topic><topic>Female</topic><topic>Humans</topic><topic>Labor, Obstetric</topic><topic>Medical sciences</topic><topic>Neuropharmacology</topic><topic>Parity</topic><topic>Pharmacology. Drug treatments</topic><topic>Pregnancy</topic><topic>Prospective Studies</topic><topic>Ropivacaine</topic><topic>Self Administration</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>OWEN, M. D</creatorcontrib><creatorcontrib>D'ANGELO, R</creatorcontrib><creatorcontrib>GERANCHER, J. C</creatorcontrib><creatorcontrib>THOMPSON, J. M</creatorcontrib><creatorcontrib>FOSS, M. L</creatorcontrib><creatorcontrib>BABB, J. D</creatorcontrib><creatorcontrib>EISENACH, J. 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C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>0.125% Ropivacaine is similar to 0.125% bupivacaine for labor analgesia using patient-controlled epidural infusion</atitle><jtitle>Anesthesia and analgesia</jtitle><addtitle>Anesth Analg</addtitle><date>1998-03-01</date><risdate>1998</risdate><volume>86</volume><issue>3</issue><spage>527</spage><epage>531</epage><pages>527-531</pages><issn>0003-2999</issn><eissn>1526-7598</eissn><coden>AACRAT</coden><abstract>We compared the effects of 0.125% ropivacaine with 0.125% bupivacaine in laboring patients using patient-controlled epidural analgesia (PCEA). Fifty-one ASA physical status I or II term parturients with functioning epidural catheters were randomized to receive ropivacaine or bupivacaine using a prospective, double-blind design. Basal infusions (6 mL/h) were supplemented with patient-controlled boluses (5 mL) every 10 min as required. For inadequate analgesia, patients were administered 10-mL boluses of study solution until comfortable. There were no differences in verbal pain scores, amount of local anesthetics used, sensory levels, motor blockade, labor duration, mode of delivery, side effects, or patient satisfaction between the two local anesthetics. We conclude that 0.125% ropivacaine and bupivacaine are clinically indistinguishable and are both highly effective for labor analgesia using PCEA.
This study compared labor analgesia from 0.125% ropivacaine and 0.125% bupivacaine using patient-controlled epidural analgesia. We found no significant differences in local anesthetic use, analgesic characteristics, or side effects between 0.125% ropivacaine and 0.125% bupivacaine. We conclude that these two drugs are clinically indistinguishable at this concentration.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott</pub><pmid>9495407</pmid><doi>10.1097/00000539-199803000-00015</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Amides - administration & dosage Analgesia, Patient-Controlled - methods Anesthesia, Epidural - methods Anesthetics, Local - administration & dosage Anesthetics. Neuromuscular blocking agents Biological and medical sciences Blood Pressure - drug effects Bupivacaine - administration & dosage Female Humans Labor, Obstetric Medical sciences Neuropharmacology Parity Pharmacology. Drug treatments Pregnancy Prospective Studies Ropivacaine Self Administration |
| title | 0.125% Ropivacaine is similar to 0.125% bupivacaine for labor analgesia using patient-controlled epidural infusion |
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