Independent existence of mutations responsible for temperature sensitivity and attenuation in a mutant of murine cytomegalovirus
A temperature-sensitive ( ts) mutant of murine cytomegalovirus, ts2l, lacks pathogenicity for suckling mice. Revertants ( rev2l) of ts21 which could replicate at nonpermissive temperature remained attenuated, suggesting the presence of a temperature-independent factor(s) for the attenuation. Coinfec...
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| Veröffentlicht in: | Virology (New York, N.Y.) N.Y.), 1990-04, Vol.175 (2), p.572-574 |
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| container_title | Virology (New York, N.Y.) |
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| creator | Kumura, Keiko Ibusuki, Kazuhiko Minamishima, Yoichi |
| description | A temperature-sensitive (
ts) mutant of murine cytomegalovirus,
ts2l, lacks pathogenicity for suckling mice. Revertants (
rev2l) of
ts21 which could replicate at nonpermissive temperature remained attenuated, suggesting the presence of a temperature-independent factor(s) for the attenuation. Coinfection of
ts21 with its parental wild-type (
wt) generated recombinant-type progenies (
rec2lw) which lacked temperature sensitivity and were still attenuated. The results indicate that
ts2l harbors at least two mutations and the mutation(s) in pathogenicity exists independently of the
ts mutation(s). |
| doi_str_mv | 10.1016/0042-6822(90)90443-U |
| format | Article |
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ts) mutant of murine cytomegalovirus,
ts2l, lacks pathogenicity for suckling mice. Revertants (
rev2l) of
ts21 which could replicate at nonpermissive temperature remained attenuated, suggesting the presence of a temperature-independent factor(s) for the attenuation. Coinfection of
ts21 with its parental wild-type (
wt) generated recombinant-type progenies (
rec2lw) which lacked temperature sensitivity and were still attenuated. The results indicate that
ts2l harbors at least two mutations and the mutation(s) in pathogenicity exists independently of the
ts mutation(s).</description><identifier>ISSN: 0042-6822</identifier><identifier>EISSN: 1096-0341</identifier><identifier>DOI: 10.1016/0042-6822(90)90443-U</identifier><identifier>PMID: 2158187</identifier><identifier>CODEN: VIRLAX</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>Animals ; Animals, Suckling ; Biological and medical sciences ; Cytomegalovirus - genetics ; Cytomegalovirus - pathogenicity ; Cytomegalovirus - physiology ; Cytomegalovirus Infections - microbiology ; Disease Models, Animal ; Fundamental and applied biological sciences. Psychology ; Genetics ; Mice ; Microbiology ; Mutation ; Phenotype ; Temperature ; Virology ; Virulence ; Virus Replication</subject><ispartof>Virology (New York, N.Y.), 1990-04, Vol.175 (2), p.572-574</ispartof><rights>1990</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-dfb2d014d11e361ab110617aee18da03a50ccecc46afaa59f4bee60dde20fe423</citedby><cites>FETCH-LOGICAL-c417t-dfb2d014d11e361ab110617aee18da03a50ccecc46afaa59f4bee60dde20fe423</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0042-6822(90)90443-U$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27928,27929,45999</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6870401$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2158187$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kumura, Keiko</creatorcontrib><creatorcontrib>Ibusuki, Kazuhiko</creatorcontrib><creatorcontrib>Minamishima, Yoichi</creatorcontrib><title>Independent existence of mutations responsible for temperature sensitivity and attenuation in a mutant of murine cytomegalovirus</title><title>Virology (New York, N.Y.)</title><addtitle>Virology</addtitle><description>A temperature-sensitive (
ts) mutant of murine cytomegalovirus,
ts2l, lacks pathogenicity for suckling mice. Revertants (
rev2l) of
ts21 which could replicate at nonpermissive temperature remained attenuated, suggesting the presence of a temperature-independent factor(s) for the attenuation. Coinfection of
ts21 with its parental wild-type (
wt) generated recombinant-type progenies (
rec2lw) which lacked temperature sensitivity and were still attenuated. The results indicate that
ts2l harbors at least two mutations and the mutation(s) in pathogenicity exists independently of the
ts mutation(s).</description><subject>Animals</subject><subject>Animals, Suckling</subject><subject>Biological and medical sciences</subject><subject>Cytomegalovirus - genetics</subject><subject>Cytomegalovirus - pathogenicity</subject><subject>Cytomegalovirus - physiology</subject><subject>Cytomegalovirus Infections - microbiology</subject><subject>Disease Models, Animal</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetics</subject><subject>Mice</subject><subject>Microbiology</subject><subject>Mutation</subject><subject>Phenotype</subject><subject>Temperature</subject><subject>Virology</subject><subject>Virulence</subject><subject>Virus Replication</subject><issn>0042-6822</issn><issn>1096-0341</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUuLFDEUhYMoY8_oP1DIQmRclN6k0vXYDMjgY2DAjb0Ot5JbEqlKlUmqsXf-dFPdTS91k0s4534J5zD2SsB7AaL6AKBkUTVS3rbwrgWlymL3hG0EtFUBpRJP2eZiec6uY_wJ-V7XcMWupNg2oqk37M-DtzRTPnzi9NvFRN4Qn3o-LgmTm3zkgeKcp-sG4v0UeKJxpoBpCcQjZSG5vUsHjt5yTBmwHBe58xyPmIw-AoPzxM0hTSP9wGHau7DEF-xZj0Okl-d5w3afP32__1o8fvvycP_xsTBK1KmwfSctCGWFoLIS2AkBlaiRSDQWocQtGEPGqAp7xG3bq46oAmtJQk9Kljfs7Yk7h-nXQjHp0UVDw4CepiXquq2lbGr1X-OaXOaJbFQnowlTjIF6PQc3YjhoAXptSK_x6zV-3YI-NqR3ee31mb90I9nL0rmSrL856xgNDn1Ab1y82KqmBgXr63cnG-XQ9o6Cjsat3VkXyCRtJ_fvf_wFLByxWQ</recordid><startdate>19900401</startdate><enddate>19900401</enddate><creator>Kumura, Keiko</creator><creator>Ibusuki, Kazuhiko</creator><creator>Minamishima, Yoichi</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19900401</creationdate><title>Independent existence of mutations responsible for temperature sensitivity and attenuation in a mutant of murine cytomegalovirus</title><author>Kumura, Keiko ; Ibusuki, Kazuhiko ; Minamishima, Yoichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-dfb2d014d11e361ab110617aee18da03a50ccecc46afaa59f4bee60dde20fe423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Animals</topic><topic>Animals, Suckling</topic><topic>Biological and medical sciences</topic><topic>Cytomegalovirus - genetics</topic><topic>Cytomegalovirus - pathogenicity</topic><topic>Cytomegalovirus - physiology</topic><topic>Cytomegalovirus Infections - microbiology</topic><topic>Disease Models, Animal</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genetics</topic><topic>Mice</topic><topic>Microbiology</topic><topic>Mutation</topic><topic>Phenotype</topic><topic>Temperature</topic><topic>Virology</topic><topic>Virulence</topic><topic>Virus Replication</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kumura, Keiko</creatorcontrib><creatorcontrib>Ibusuki, Kazuhiko</creatorcontrib><creatorcontrib>Minamishima, Yoichi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Virology (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kumura, Keiko</au><au>Ibusuki, Kazuhiko</au><au>Minamishima, Yoichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Independent existence of mutations responsible for temperature sensitivity and attenuation in a mutant of murine cytomegalovirus</atitle><jtitle>Virology (New York, N.Y.)</jtitle><addtitle>Virology</addtitle><date>1990-04-01</date><risdate>1990</risdate><volume>175</volume><issue>2</issue><spage>572</spage><epage>574</epage><pages>572-574</pages><issn>0042-6822</issn><eissn>1096-0341</eissn><coden>VIRLAX</coden><abstract>A temperature-sensitive (
ts) mutant of murine cytomegalovirus,
ts2l, lacks pathogenicity for suckling mice. Revertants (
rev2l) of
ts21 which could replicate at nonpermissive temperature remained attenuated, suggesting the presence of a temperature-independent factor(s) for the attenuation. Coinfection of
ts21 with its parental wild-type (
wt) generated recombinant-type progenies (
rec2lw) which lacked temperature sensitivity and were still attenuated. The results indicate that
ts2l harbors at least two mutations and the mutation(s) in pathogenicity exists independently of the
ts mutation(s).</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>2158187</pmid><doi>10.1016/0042-6822(90)90443-U</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Virology (New York, N.Y.), 1990-04, Vol.175 (2), p.572-574 |
| issn | 0042-6822 1096-0341 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier); EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Animals, Suckling Biological and medical sciences Cytomegalovirus - genetics Cytomegalovirus - pathogenicity Cytomegalovirus - physiology Cytomegalovirus Infections - microbiology Disease Models, Animal Fundamental and applied biological sciences. Psychology Genetics Mice Microbiology Mutation Phenotype Temperature Virology Virulence Virus Replication |
| title | Independent existence of mutations responsible for temperature sensitivity and attenuation in a mutant of murine cytomegalovirus |
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