Abnormalities of Striatal Projection Neurons and N-Methyl-D-Aspartate Receptors in Presymptomatic Huntington's Disease

HUNTINGTON'S disease is an autosomal dominant disease characterized by slowly progressive personality changes, dementia, and movement disorders. 1 , 2 The average age at onset is 30 to 40 years, and the disease lasts for an average of 15 to 20 years. Analysis with restriction-fragmentlength pol...

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Veröffentlicht in:	The New England journal of medicine 1990-05, Vol.322 (18), p.1293-1298
Hauptverfasser:	Albin, Roger L, Young, Anne B, Penney, John B, Handelin, Barbara, Balfour, Rosemary, Anderson, Keith D, Markel, Dorene S, Tourtellotte, Wallace W, Reiner, Anton
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aspartic Acid - analogs & derivatives Aspartic Acid - metabolism Biological and medical sciences Corpus Striatum - analysis Corpus Striatum - pathology Disease Female Health care Heterozygote Humans Huntington Disease - genetics Huntington Disease - metabolism Huntington Disease - pathology Immunohistochemistry Medical disorders Medical research Medical sciences N-Methylaspartate Neurology Neurons - pathology Receptors, N-Methyl-D-Aspartate Receptors, Neurotransmitter - analysis Substance P - analysis Suicide
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