Inhibition of Erythroid Progenitor Cells by Anti-Kell Antibodies in Fetal Alloimmune Anemia
The Kell blood-group system is one of the major antigenic systems in human red cells. It consists of 23 known antigens that reside on one 93-kd transmembrane protein encoded by a single gene on chromosome 7 (7q33). 1 , 2 The Kell antigen is expressed only by erythroid progenitor cells and mature ery...
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| Veröffentlicht in: | The New England journal of medicine 1998-03, Vol.338 (12), p.798-803 |
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| creator | Vaughan, Janet I Manning, Monica Warwick, Ruth M Letsky, Elizabeth A Murray, Neil A Roberts, Irene A.G |
| description | The Kell blood-group system is one of the major antigenic systems in human red cells. It consists of 23 known antigens that reside on one 93-kd transmembrane protein encoded by a single gene on chromosome 7 (7q33).
1
,
2
The Kell antigen is expressed only by erythroid progenitor cells and mature erythroid cells.
1
,
3
,
4
The Kell blood group is important in clinical medicine because antibodies to the principal antigen, K1, cause both life-threatening transfusion reactions and severe alloimmune anemia in Kell-positive fetuses and newborn infants.
5
,
6
Alloimmunization occurs when Kell-negative women, who do not have the K1 antigen on their . . . |
| doi_str_mv | 10.1056/NEJM199803193381204 |
| format | Article |
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1
,
2
The Kell antigen is expressed only by erythroid progenitor cells and mature erythroid cells.
1
,
3
,
4
The Kell blood group is important in clinical medicine because antibodies to the principal antigen, K1, cause both life-threatening transfusion reactions and severe alloimmune anemia in Kell-positive fetuses and newborn infants.
5
,
6
Alloimmunization occurs when Kell-negative women, who do not have the K1 antigen on their . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJM199803193381204</identifier><identifier>PMID: 9504940</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>Boston, MA: Massachusetts Medical Society</publisher><subject>Anemia ; Anemia, Hemolytic, Autoimmune ; Anemias. Hemoglobinopathies ; Antibodies, Monoclonal - physiology ; Biological and medical sciences ; Cell Division - immunology ; Cells ; Diseases of red blood cells ; Erythroblastosis, Fetal - blood ; Erythroblastosis, Fetal - etiology ; Erythroblastosis, Fetal - immunology ; Erythroid Precursor Cells - immunology ; Erythroid Precursor Cells - physiology ; Erythropoiesis - immunology ; Female ; Fetal Blood - immunology ; Fetuses ; Hematologic and hematopoietic diseases ; Hematopoietic Stem Cells - physiology ; Humans ; Immunity (Disease) ; Infant, Newborn ; Isoantibodies - physiology ; Kell Blood-Group System - immunology ; Medical research ; Medical sciences ; Pregnancy ; Rh-Hr Blood-Group System - immunology ; Severity of Illness Index</subject><ispartof>The New England journal of medicine, 1998-03, Vol.338 (12), p.798-803</ispartof><rights>Copyright © 1998 Massachusetts Medical Society. All rights reserved.</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c623t-bee8922d437ee97d093be7d2fdb9e26712a20b56607a16e3e6293856278fcb473</citedby><cites>FETCH-LOGICAL-c623t-bee8922d437ee97d093be7d2fdb9e26712a20b56607a16e3e6293856278fcb473</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJM199803193381204$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJM199803193381204$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>314,776,780,2746,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2176867$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9504940$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vaughan, Janet I</creatorcontrib><creatorcontrib>Manning, Monica</creatorcontrib><creatorcontrib>Warwick, Ruth M</creatorcontrib><creatorcontrib>Letsky, Elizabeth A</creatorcontrib><creatorcontrib>Murray, Neil A</creatorcontrib><creatorcontrib>Roberts, Irene A.G</creatorcontrib><title>Inhibition of Erythroid Progenitor Cells by Anti-Kell Antibodies in Fetal Alloimmune Anemia</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>The Kell blood-group system is one of the major antigenic systems in human red cells. It consists of 23 known antigens that reside on one 93-kd transmembrane protein encoded by a single gene on chromosome 7 (7q33).
1
,
2
The Kell antigen is expressed only by erythroid progenitor cells and mature erythroid cells.
1
,
3
,
4
The Kell blood group is important in clinical medicine because antibodies to the principal antigen, K1, cause both life-threatening transfusion reactions and severe alloimmune anemia in Kell-positive fetuses and newborn infants.
5
,
6
Alloimmunization occurs when Kell-negative women, who do not have the K1 antigen on their . . .</description><subject>Anemia</subject><subject>Anemia, Hemolytic, Autoimmune</subject><subject>Anemias. Hemoglobinopathies</subject><subject>Antibodies, Monoclonal - physiology</subject><subject>Biological and medical sciences</subject><subject>Cell Division - immunology</subject><subject>Cells</subject><subject>Diseases of red blood cells</subject><subject>Erythroblastosis, Fetal - blood</subject><subject>Erythroblastosis, Fetal - etiology</subject><subject>Erythroblastosis, Fetal - immunology</subject><subject>Erythroid Precursor Cells - immunology</subject><subject>Erythroid Precursor Cells - physiology</subject><subject>Erythropoiesis - immunology</subject><subject>Female</subject><subject>Fetal Blood - immunology</subject><subject>Fetuses</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hematopoietic Stem Cells - physiology</subject><subject>Humans</subject><subject>Immunity (Disease)</subject><subject>Infant, Newborn</subject><subject>Isoantibodies - physiology</subject><subject>Kell Blood-Group System - immunology</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Pregnancy</subject><subject>Rh-Hr Blood-Group System - immunology</subject><subject>Severity of Illness Index</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkU1P3DAQhi3UChbKL6gqRVXVSxXqr_jjiFYLpXy0h3LiENnJBLyKbWonh_33Nd0VB4RaX2zP-8x4xi9C7wk-IbgRX29W36-J1gozohlThGK-hxakYazmHIs3aIExVTWXmh2gw5zXuCzC9T7a1w3mmuMFursID866ycVQxaFapc30kKLrq58p3kNwU0zVEsYxV3ZTnYbJ1Zfl9vdkY-8gVy5UZzCZEhvH6LyfAxQZvDPv0NvBjBmOd_sRuj1b_Vp-q69-nF8sT6_qTlA21RZAaUp7ziSAlj3WzILs6dBbDVRIQg3FthECS0MEMBBUM9UIKtXQWS7ZEfq8rfuY4u8Z8tR6l7vSpgkQ59xKLSnRXPwXJIKp8kW8gB9fgOs4p1CGaCllmiuhmwKxLdSlmHOCoX1Mzpu0aQlunwxqXzGoZH3YlZ6th_45Z-dI0T_tdJM7Mw7JhM7lZ4wSKZR4mvnLFvM-twHW_p-P_gGQH6Jm</recordid><startdate>19980319</startdate><enddate>19980319</enddate><creator>Vaughan, Janet I</creator><creator>Manning, Monica</creator><creator>Warwick, Ruth M</creator><creator>Letsky, Elizabeth A</creator><creator>Murray, Neil A</creator><creator>Roberts, Irene A.G</creator><general>Massachusetts Medical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19980319</creationdate><title>Inhibition of Erythroid Progenitor Cells by Anti-Kell Antibodies in Fetal Alloimmune Anemia</title><author>Vaughan, Janet I ; Manning, Monica ; Warwick, Ruth M ; Letsky, Elizabeth A ; Murray, Neil A ; Roberts, Irene A.G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c623t-bee8922d437ee97d093be7d2fdb9e26712a20b56607a16e3e6293856278fcb473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Anemia</topic><topic>Anemia, Hemolytic, Autoimmune</topic><topic>Anemias. Hemoglobinopathies</topic><topic>Antibodies, Monoclonal - physiology</topic><topic>Biological and medical sciences</topic><topic>Cell Division - immunology</topic><topic>Cells</topic><topic>Diseases of red blood cells</topic><topic>Erythroblastosis, Fetal - blood</topic><topic>Erythroblastosis, Fetal - etiology</topic><topic>Erythroblastosis, Fetal - immunology</topic><topic>Erythroid Precursor Cells - immunology</topic><topic>Erythroid Precursor Cells - physiology</topic><topic>Erythropoiesis - immunology</topic><topic>Female</topic><topic>Fetal Blood - immunology</topic><topic>Fetuses</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Hematopoietic Stem Cells - physiology</topic><topic>Humans</topic><topic>Immunity (Disease)</topic><topic>Infant, Newborn</topic><topic>Isoantibodies - physiology</topic><topic>Kell Blood-Group System - immunology</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Pregnancy</topic><topic>Rh-Hr Blood-Group System - immunology</topic><topic>Severity of Illness Index</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vaughan, Janet I</creatorcontrib><creatorcontrib>Manning, Monica</creatorcontrib><creatorcontrib>Warwick, Ruth M</creatorcontrib><creatorcontrib>Letsky, Elizabeth A</creatorcontrib><creatorcontrib>Murray, Neil A</creatorcontrib><creatorcontrib>Roberts, Irene A.G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>New England Journal of Medicine</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vaughan, Janet I</au><au>Manning, Monica</au><au>Warwick, Ruth M</au><au>Letsky, Elizabeth A</au><au>Murray, Neil A</au><au>Roberts, Irene A.G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibition of Erythroid Progenitor Cells by Anti-Kell Antibodies in Fetal Alloimmune Anemia</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>1998-03-19</date><risdate>1998</risdate><volume>338</volume><issue>12</issue><spage>798</spage><epage>803</epage><pages>798-803</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><coden>NEJMAG</coden><abstract>The Kell blood-group system is one of the major antigenic systems in human red cells. It consists of 23 known antigens that reside on one 93-kd transmembrane protein encoded by a single gene on chromosome 7 (7q33).
1
,
2
The Kell antigen is expressed only by erythroid progenitor cells and mature erythroid cells.
1
,
3
,
4
The Kell blood group is important in clinical medicine because antibodies to the principal antigen, K1, cause both life-threatening transfusion reactions and severe alloimmune anemia in Kell-positive fetuses and newborn infants.
5
,
6
Alloimmunization occurs when Kell-negative women, who do not have the K1 antigen on their . . .</abstract><cop>Boston, MA</cop><pub>Massachusetts Medical Society</pub><pmid>9504940</pmid><doi>10.1056/NEJM199803193381204</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 1998-03, Vol.338 (12), p.798-803 |
| issn | 0028-4793 1533-4406 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79721946 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; New England Journal of Medicine |
| subjects | Anemia Anemia, Hemolytic, Autoimmune Anemias. Hemoglobinopathies Antibodies, Monoclonal - physiology Biological and medical sciences Cell Division - immunology Cells Diseases of red blood cells Erythroblastosis, Fetal - blood Erythroblastosis, Fetal - etiology Erythroblastosis, Fetal - immunology Erythroid Precursor Cells - immunology Erythroid Precursor Cells - physiology Erythropoiesis - immunology Female Fetal Blood - immunology Fetuses Hematologic and hematopoietic diseases Hematopoietic Stem Cells - physiology Humans Immunity (Disease) Infant, Newborn Isoantibodies - physiology Kell Blood-Group System - immunology Medical research Medical sciences Pregnancy Rh-Hr Blood-Group System - immunology Severity of Illness Index |
| title | Inhibition of Erythroid Progenitor Cells by Anti-Kell Antibodies in Fetal Alloimmune Anemia |
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