Vaginal immunization of Cynomolgus monkeys with Streptococcus gordonii expressing HIV-1 and HPV 16 antigens
Cynomolgus monkeys ( Macaca fascicularis) were immunized by intravaginal administration of live recombinant Streptococcus gordonii. The vaccine strains of S. gordonii expressed the V3 domain of the gp120 of human immunodeficiency virus type 1 (HIV-1), and the E7 protein of human papillomavirus type...
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| Veröffentlicht in: | Vaccine 1998-03, Vol.16 (5), p.485-492 |
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| container_title | Vaccine |
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| creator | Di Fabio, S. Medaglini, D. Rush, C.M. Corrias, F. Panzini, G.L. Pace, M. Verani, P. Pozzi, G. Titti, F. |
| description | Cynomolgus monkeys (
Macaca fascicularis) were immunized by intravaginal administration of live recombinant
Streptococcus gordonii. The vaccine strains of
S. gordonii expressed the V3 domain of the gp120 of human immunodeficiency virus type 1 (HIV-1), and the E7 protein of human papillomavirus type 16 (HPV 16). Multiple inocula of recombinant bacteria were used, since
S. gordonii could persist for no longer than 3 days in the monkey vagina. Vaginal immunization was found to induce a local and systemic immune response specific for the heterologous antigen expressed by the bacteria. This antigen-specific immune response consisted of vaginal IgA, serum IgG, and a T-cell proliferative response measured on PBMCs. Vaginal IgG and serum IgA were not detected. |
| doi_str_mv | 10.1016/S0264-410X(97)80002-3 |
| format | Article |
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Macaca fascicularis) were immunized by intravaginal administration of live recombinant
Streptococcus gordonii. The vaccine strains of
S. gordonii expressed the V3 domain of the gp120 of human immunodeficiency virus type 1 (HIV-1), and the E7 protein of human papillomavirus type 16 (HPV 16). Multiple inocula of recombinant bacteria were used, since
S. gordonii could persist for no longer than 3 days in the monkey vagina. Vaginal immunization was found to induce a local and systemic immune response specific for the heterologous antigen expressed by the bacteria. This antigen-specific immune response consisted of vaginal IgA, serum IgG, and a T-cell proliferative response measured on PBMCs. Vaginal IgG and serum IgA were not detected.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/S0264-410X(97)80002-3</identifier><identifier>PMID: 9491503</identifier><identifier>CODEN: VACCDE</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>AIDS/HIV ; Animals ; Antibodies, Bacterial - biosynthesis ; Antibody Specificity ; Antigens, Viral - immunology ; Bacterial Vaccines ; Biological and medical sciences ; Female ; Fundamental and applied biological sciences. Psychology ; HIV Antigens - immunology ; Immunization ; Macaca fascicularis ; Microbiology ; mucosal vaccines ; Papillomaviridae - immunology ; recombinant vaccines ; Streptococcus - immunology ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies ; Vagina - immunology ; vaginal immunization ; Virology</subject><ispartof>Vaccine, 1998-03, Vol.16 (5), p.485-492</ispartof><rights>1998</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-794f1c4bfe52f40ab05eed41d23f8d4270e661584e469b75df61e53e12df86f53</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0264-410X(97)80002-3$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3554,27933,27934,46004</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2179454$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9491503$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Di Fabio, S.</creatorcontrib><creatorcontrib>Medaglini, D.</creatorcontrib><creatorcontrib>Rush, C.M.</creatorcontrib><creatorcontrib>Corrias, F.</creatorcontrib><creatorcontrib>Panzini, G.L.</creatorcontrib><creatorcontrib>Pace, M.</creatorcontrib><creatorcontrib>Verani, P.</creatorcontrib><creatorcontrib>Pozzi, G.</creatorcontrib><creatorcontrib>Titti, F.</creatorcontrib><title>Vaginal immunization of Cynomolgus monkeys with Streptococcus gordonii expressing HIV-1 and HPV 16 antigens</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>Cynomolgus monkeys (
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Streptococcus gordonii. The vaccine strains of
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S. gordonii could persist for no longer than 3 days in the monkey vagina. Vaginal immunization was found to induce a local and systemic immune response specific for the heterologous antigen expressed by the bacteria. This antigen-specific immune response consisted of vaginal IgA, serum IgG, and a T-cell proliferative response measured on PBMCs. Vaginal IgG and serum IgA were not detected.</description><subject>AIDS/HIV</subject><subject>Animals</subject><subject>Antibodies, Bacterial - biosynthesis</subject><subject>Antibody Specificity</subject><subject>Antigens, Viral - immunology</subject><subject>Bacterial Vaccines</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>HIV Antigens - immunology</subject><subject>Immunization</subject><subject>Macaca fascicularis</subject><subject>Microbiology</subject><subject>mucosal vaccines</subject><subject>Papillomaviridae - immunology</subject><subject>recombinant vaccines</subject><subject>Streptococcus - immunology</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies</subject><subject>Vagina - immunology</subject><subject>vaginal immunization</subject><subject>Virology</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV9rFDEUxYModa1-hEIeRPRhNMkkmcmTyFLdQqGF6uJbyCY3Y-xMsk1mquund9pd9rVP98L53T-cg9AZJR8pofLTDWGSV5ySn-9V86ElhLCqfoYWtG3qignaPkeLI_ISvSrl98yImqoTdKK4ooLUC3S7Nl2IpsdhGKYY_pkxpIiTx8tdTEPqu6ngIcVb2BX8J4y_8M2YYTsmm6ydpS5ll2IIGP5uM5QSYodXF-uKYhMdXl2vMZVzO4YOYnmNXnjTF3hzqKfox9fz78tVdXn17WL55bKynLGxahT31PKNB8E8J2ZDBIDj1LHat46zhoCUVLQcuFSbRjgvKYgaKHO-lV7Up-jdfu82p7sJyqiHUCz0vYmQpqIb1TDaKvUkSCVrScPlDIo9aHMqJYPX2xwGk3eaEv2Qhn5MQz9YrVWjH9PQ9Tx3djgwbQZwx6mD_bP-9qCbYk3vs4k2lCPG6OyF4DP2eY_B7Np9gKyLDRAtuJDBjtql8MQj_wH5WacF</recordid><startdate>19980301</startdate><enddate>19980301</enddate><creator>Di Fabio, S.</creator><creator>Medaglini, D.</creator><creator>Rush, C.M.</creator><creator>Corrias, F.</creator><creator>Panzini, G.L.</creator><creator>Pace, M.</creator><creator>Verani, P.</creator><creator>Pozzi, G.</creator><creator>Titti, F.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T5</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19980301</creationdate><title>Vaginal immunization of Cynomolgus monkeys with Streptococcus gordonii expressing HIV-1 and HPV 16 antigens</title><author>Di Fabio, S. ; Medaglini, D. ; Rush, C.M. ; Corrias, F. ; Panzini, G.L. ; Pace, M. ; Verani, P. ; Pozzi, G. ; Titti, F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-794f1c4bfe52f40ab05eed41d23f8d4270e661584e469b75df61e53e12df86f53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>AIDS/HIV</topic><topic>Animals</topic><topic>Antibodies, Bacterial - biosynthesis</topic><topic>Antibody Specificity</topic><topic>Antigens, Viral - immunology</topic><topic>Bacterial Vaccines</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. 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Macaca fascicularis) were immunized by intravaginal administration of live recombinant
Streptococcus gordonii. The vaccine strains of
S. gordonii expressed the V3 domain of the gp120 of human immunodeficiency virus type 1 (HIV-1), and the E7 protein of human papillomavirus type 16 (HPV 16). Multiple inocula of recombinant bacteria were used, since
S. gordonii could persist for no longer than 3 days in the monkey vagina. Vaginal immunization was found to induce a local and systemic immune response specific for the heterologous antigen expressed by the bacteria. This antigen-specific immune response consisted of vaginal IgA, serum IgG, and a T-cell proliferative response measured on PBMCs. Vaginal IgG and serum IgA were not detected.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>9491503</pmid><doi>10.1016/S0264-410X(97)80002-3</doi><tpages>8</tpages></addata></record> |
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| ispartof | Vaccine, 1998-03, Vol.16 (5), p.485-492 |
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| language | eng |
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| subjects | AIDS/HIV Animals Antibodies, Bacterial - biosynthesis Antibody Specificity Antigens, Viral - immunology Bacterial Vaccines Biological and medical sciences Female Fundamental and applied biological sciences. Psychology HIV Antigens - immunology Immunization Macaca fascicularis Microbiology mucosal vaccines Papillomaviridae - immunology recombinant vaccines Streptococcus - immunology Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Vagina - immunology vaginal immunization Virology |
| title | Vaginal immunization of Cynomolgus monkeys with Streptococcus gordonii expressing HIV-1 and HPV 16 antigens |
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