Antagonism of 5-HT3 receptor mediated currents in murine N1E-115 neuroblastoma cells by (+)-tubocurarine

5-HT3 receptor-mediated membrane currents were recorded from voltage-clamped clonal N1E-115 neuroblastoma cells. The inward current response to ionophoretically applied serotonin (5-HT) was reversibly antagonised by the 5-HT3 receptor antagonists GR 38032F and metoclopramide with IC50 values of 0.2...

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Veröffentlicht in:	Neuroscience letters 1990-03, Vol.110 (1-2), p.107-112
Hauptverfasser:	PETERS, J. A, MALONE, H. M, LAMBERT, J. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Line Cell receptors Cell structures and functions Fundamental and applied biological sciences. Psychology Imidazoles - pharmacology Ion Channels - drug effects Ion Channels - physiology Membrane Potentials - drug effects Mice Molecular and cellular biology Neuroblastoma Neurons - drug effects Neurons - physiology Ondansetron Receptors, Nicotinic - drug effects Receptors, Serotonin - drug effects Receptors, Serotonin - physiology Serotonin Antagonists Tubocurarine - pharmacology
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