Establishment and characterization of a new mammary adenocarcinoma cell line derived from MMTV neu transgenic mice
A new murine cell line, named MG1361, was established from mammary adenocarcinomas arising in a MMTV-neu transgenic mouse lineage where breast tumors develop in 100% of females, due to the overexpression of the activated rat neu oncogene in the mammary gland. The MG1361 cell line shows an epithelial...
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| Veröffentlicht in: | Breast cancer research and treatment 1998, Vol.47 (2), p.171-180 |
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| creator | SACCO, M. G GRIBALDO, L MARAFANTE, E VEZZONI, P BARBIERI, O TURCHI, G ZUCCHI, I COLLOTTA, A BAGNASCO, L BARONE, D MONTAGNA, C VILLA, A |
| description | A new murine cell line, named MG1361, was established from mammary adenocarcinomas arising in a MMTV-neu transgenic mouse lineage where breast tumors develop in 100% of females, due to the overexpression of the activated rat neu oncogene in the mammary gland. The MG1361 cell line shows an epithelial-like morphology, has a poor plating efficiency, low clonogenic capacity, and a doubling time of 23.8 hours. Karyotype and flow cytometry analysis revealed a hypotetraploid number of chromosomes, whereas cell cycle analysis showed 31.2% of cells to be in the G1 phase, 21.4% in S and 47.4% in G2 + M. This cell line maintains a high level of neu expression in vitro. The MG1361 cell line was tumorigenic when inoculated in immunodeficient (nude) mice and the derived tumors showed the same histological features as the primary tumors from which they were isolated. MG1361 cells were positive for specific ER and PgR binding which was competed by tamoxifen, making this cell line useful for the evaluation of endocrine therapy. Moreover, they were sensitive to etoposide treatment, suggesting that they could be a model for the study of chemotherapy-induced apoptosis. As the tumors arising in MMTV-neu transgenic mice have many features in common with human mammary adenocarcinomas (Sacco et al., Gene Therapy 1995; 2: 493-497), this cell line can be utilized to perform basic studies on the role of the neu oncogene in the maintenance of the transformed phenotype, and to test novel protocols of therapeutic strategies. |
| doi_str_mv | 10.1023/A:1005988715285 |
| format | Article |
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G ; GRIBALDO, L ; MARAFANTE, E ; VEZZONI, P ; BARBIERI, O ; TURCHI, G ; ZUCCHI, I ; COLLOTTA, A ; BAGNASCO, L ; BARONE, D ; MONTAGNA, C ; VILLA, A</creator><creatorcontrib>SACCO, M. G ; GRIBALDO, L ; MARAFANTE, E ; VEZZONI, P ; BARBIERI, O ; TURCHI, G ; ZUCCHI, I ; COLLOTTA, A ; BAGNASCO, L ; BARONE, D ; MONTAGNA, C ; VILLA, A</creatorcontrib><description>A new murine cell line, named MG1361, was established from mammary adenocarcinomas arising in a MMTV-neu transgenic mouse lineage where breast tumors develop in 100% of females, due to the overexpression of the activated rat neu oncogene in the mammary gland. The MG1361 cell line shows an epithelial-like morphology, has a poor plating efficiency, low clonogenic capacity, and a doubling time of 23.8 hours. Karyotype and flow cytometry analysis revealed a hypotetraploid number of chromosomes, whereas cell cycle analysis showed 31.2% of cells to be in the G1 phase, 21.4% in S and 47.4% in G2 + M. This cell line maintains a high level of neu expression in vitro. The MG1361 cell line was tumorigenic when inoculated in immunodeficient (nude) mice and the derived tumors showed the same histological features as the primary tumors from which they were isolated. MG1361 cells were positive for specific ER and PgR binding which was competed by tamoxifen, making this cell line useful for the evaluation of endocrine therapy. Moreover, they were sensitive to etoposide treatment, suggesting that they could be a model for the study of chemotherapy-induced apoptosis. As the tumors arising in MMTV-neu transgenic mice have many features in common with human mammary adenocarcinomas (Sacco et al., Gene Therapy 1995; 2: 493-497), this cell line can be utilized to perform basic studies on the role of the neu oncogene in the maintenance of the transformed phenotype, and to test novel protocols of therapeutic strategies.</description><identifier>ISSN: 0167-6806</identifier><identifier>EISSN: 1573-7217</identifier><identifier>DOI: 10.1023/A:1005988715285</identifier><identifier>PMID: 9497105</identifier><identifier>CODEN: BCTRD6</identifier><language>eng</language><publisher>Dordrecht: Springer</publisher><subject>Adenocarcinoma ; Animals ; Biological and medical sciences ; Breast cancer ; Breast Neoplasms ; Cancer research ; Cell cycle ; Culture Techniques ; Female ; Flow Cytometry ; Gene therapy ; Gynecology. Andrology. Obstetrics ; Karyotyping ; Mammary gland diseases ; Medical sciences ; Mice ; Mice, Transgenic ; Mouse mammary tumor virus ; Proteins ; Receptor, ErbB-2 - genetics ; Receptors, Estrogen - analysis ; Receptors, Progesterone - analysis ; Rodents ; Tumor Cells, Cultured - ultrastructure ; Tumors</subject><ispartof>Breast cancer research and treatment, 1998, Vol.47 (2), p.171-180</ispartof><rights>1998 INIST-CNRS</rights><rights>Kluwer Academic Publishers 1998</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-f35e767edb943f9951021151a0353bc966fb91d24b87f0f78da7dd118ba3cebc3</citedby><cites>FETCH-LOGICAL-c384t-f35e767edb943f9951021151a0353bc966fb91d24b87f0f78da7dd118ba3cebc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,4012,27910,27911,27912</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2140448$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9497105$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SACCO, M. G</creatorcontrib><creatorcontrib>GRIBALDO, L</creatorcontrib><creatorcontrib>MARAFANTE, E</creatorcontrib><creatorcontrib>VEZZONI, P</creatorcontrib><creatorcontrib>BARBIERI, O</creatorcontrib><creatorcontrib>TURCHI, G</creatorcontrib><creatorcontrib>ZUCCHI, I</creatorcontrib><creatorcontrib>COLLOTTA, A</creatorcontrib><creatorcontrib>BAGNASCO, L</creatorcontrib><creatorcontrib>BARONE, D</creatorcontrib><creatorcontrib>MONTAGNA, C</creatorcontrib><creatorcontrib>VILLA, A</creatorcontrib><title>Establishment and characterization of a new mammary adenocarcinoma cell line derived from MMTV neu transgenic mice</title><title>Breast cancer research and treatment</title><addtitle>Breast Cancer Res Treat</addtitle><description>A new murine cell line, named MG1361, was established from mammary adenocarcinomas arising in a MMTV-neu transgenic mouse lineage where breast tumors develop in 100% of females, due to the overexpression of the activated rat neu oncogene in the mammary gland. The MG1361 cell line shows an epithelial-like morphology, has a poor plating efficiency, low clonogenic capacity, and a doubling time of 23.8 hours. Karyotype and flow cytometry analysis revealed a hypotetraploid number of chromosomes, whereas cell cycle analysis showed 31.2% of cells to be in the G1 phase, 21.4% in S and 47.4% in G2 + M. This cell line maintains a high level of neu expression in vitro. The MG1361 cell line was tumorigenic when inoculated in immunodeficient (nude) mice and the derived tumors showed the same histological features as the primary tumors from which they were isolated. MG1361 cells were positive for specific ER and PgR binding which was competed by tamoxifen, making this cell line useful for the evaluation of endocrine therapy. Moreover, they were sensitive to etoposide treatment, suggesting that they could be a model for the study of chemotherapy-induced apoptosis. As the tumors arising in MMTV-neu transgenic mice have many features in common with human mammary adenocarcinomas (Sacco et al., Gene Therapy 1995; 2: 493-497), this cell line can be utilized to perform basic studies on the role of the neu oncogene in the maintenance of the transformed phenotype, and to test novel protocols of therapeutic strategies.</description><subject>Adenocarcinoma</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Breast cancer</subject><subject>Breast Neoplasms</subject><subject>Cancer research</subject><subject>Cell cycle</subject><subject>Culture Techniques</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>Gene therapy</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Karyotyping</subject><subject>Mammary gland diseases</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Transgenic</subject><subject>Mouse mammary tumor virus</subject><subject>Proteins</subject><subject>Receptor, ErbB-2 - genetics</subject><subject>Receptors, Estrogen - analysis</subject><subject>Receptors, Progesterone - analysis</subject><subject>Rodents</subject><subject>Tumor Cells, Cultured - ultrastructure</subject><subject>Tumors</subject><issn>0167-6806</issn><issn>1573-7217</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp90c1rFTEQAPAgSn2tnj0JAYt4WZtskk3i7VFaFVq8VK_LbD5syiapya7S_vXm0UfBHjzNYX4zzAdCbyj5SEnPTrafKCFCKyWp6JV4hjZUSNbJnsrnaEPoILtBkeElOqz1hhCiJdEH6EBzLSkRG1TO6gLTHOp1dGnBkCw211DALK6Ee1hCTjh7DDi5PzhCjFDuMFiXsoFiQsoRsHHzjOeQHLat6Lez2Jcc8eXl1Y9WtuKlQKo_XQoGx2DcK_TCw1zd6308Qt_Pz65Ov3QX3z5_Pd1edIYpvnSeCScH6eykOfNai7YvpYICYYJNRg-DnzS1PZ-U9MRLZUFaS6magBk3GXaE3j_0vS351-rqMsZQd7NCcnmto9SyJ0oNDX74L6RSMEFUP_BG3z2hN3ktqa0xtvEk5ZzQnTp5UKbkWovz420Ju8s1tHNs3I7_vK1VvN33Xafo7KPf_6nlj_d5qAZm3y5qQn1kPeWEc8X-AkWMnss</recordid><startdate>1998</startdate><enddate>1998</enddate><creator>SACCO, M. 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Obstetrics</topic><topic>Karyotyping</topic><topic>Mammary gland diseases</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Transgenic</topic><topic>Mouse mammary tumor virus</topic><topic>Proteins</topic><topic>Receptor, ErbB-2 - genetics</topic><topic>Receptors, Estrogen - analysis</topic><topic>Receptors, Progesterone - analysis</topic><topic>Rodents</topic><topic>Tumor Cells, Cultured - ultrastructure</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SACCO, M. 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G</au><au>GRIBALDO, L</au><au>MARAFANTE, E</au><au>VEZZONI, P</au><au>BARBIERI, O</au><au>TURCHI, G</au><au>ZUCCHI, I</au><au>COLLOTTA, A</au><au>BAGNASCO, L</au><au>BARONE, D</au><au>MONTAGNA, C</au><au>VILLA, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Establishment and characterization of a new mammary adenocarcinoma cell line derived from MMTV neu transgenic mice</atitle><jtitle>Breast cancer research and treatment</jtitle><addtitle>Breast Cancer Res Treat</addtitle><date>1998</date><risdate>1998</risdate><volume>47</volume><issue>2</issue><spage>171</spage><epage>180</epage><pages>171-180</pages><issn>0167-6806</issn><eissn>1573-7217</eissn><coden>BCTRD6</coden><abstract>A new murine cell line, named MG1361, was established from mammary adenocarcinomas arising in a MMTV-neu transgenic mouse lineage where breast tumors develop in 100% of females, due to the overexpression of the activated rat neu oncogene in the mammary gland. The MG1361 cell line shows an epithelial-like morphology, has a poor plating efficiency, low clonogenic capacity, and a doubling time of 23.8 hours. Karyotype and flow cytometry analysis revealed a hypotetraploid number of chromosomes, whereas cell cycle analysis showed 31.2% of cells to be in the G1 phase, 21.4% in S and 47.4% in G2 + M. This cell line maintains a high level of neu expression in vitro. The MG1361 cell line was tumorigenic when inoculated in immunodeficient (nude) mice and the derived tumors showed the same histological features as the primary tumors from which they were isolated. MG1361 cells were positive for specific ER and PgR binding which was competed by tamoxifen, making this cell line useful for the evaluation of endocrine therapy. Moreover, they were sensitive to etoposide treatment, suggesting that they could be a model for the study of chemotherapy-induced apoptosis. As the tumors arising in MMTV-neu transgenic mice have many features in common with human mammary adenocarcinomas (Sacco et al., Gene Therapy 1995; 2: 493-497), this cell line can be utilized to perform basic studies on the role of the neu oncogene in the maintenance of the transformed phenotype, and to test novel protocols of therapeutic strategies.</abstract><cop>Dordrecht</cop><pub>Springer</pub><pmid>9497105</pmid><doi>10.1023/A:1005988715285</doi><tpages>10</tpages></addata></record> |
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| subjects | Adenocarcinoma Animals Biological and medical sciences Breast cancer Breast Neoplasms Cancer research Cell cycle Culture Techniques Female Flow Cytometry Gene therapy Gynecology. Andrology. Obstetrics Karyotyping Mammary gland diseases Medical sciences Mice Mice, Transgenic Mouse mammary tumor virus Proteins Receptor, ErbB-2 - genetics Receptors, Estrogen - analysis Receptors, Progesterone - analysis Rodents Tumor Cells, Cultured - ultrastructure Tumors |
| title | Establishment and characterization of a new mammary adenocarcinoma cell line derived from MMTV neu transgenic mice |
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